Zavzpret (zavegepant) is a prescription drug that’s used to treat migraine episodes. The drug comes as a nasal spray. It’s usually given as a single dose to treat a migraine episode.

Zavzpret is used in adults to treat migraine episodes with or without aura.

The active ingredient in Zavzpret is zavegepant. (An active ingredient is what makes a drug work.) Zavzpret belongs to a group of drugs called calcitonin gene-related peptide (CGRP) antagonists.

This article describes the dosage of Zavzpret, as well as its strength and how to use it. To learn more about Zavzpret, see this in-depth article.

This section describes the usual dosage of Zavzpret. Keep reading to learn more.

What is Zavzpret’s form?

Zavzpret is available as a single-dose nasal spray.

What strength does Zavzpret come in?

Zavzpret comes in one strength of 10 milligrams (mg) per nasal spray device. Each carton of Zavzpret contains six single-dose devices.

What are the usual dosages of Zavzpret?

Your doctor will recommend the dosage that provides the desired effect.

The information below describes dosages that are commonly used or recommended. But be sure to use the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosage for migraine

The typical Zavzpret dosage to treat migraine episodes (with or without aura) in adults is 10 mg. It’s given as one spray into a single nostril.

The maximum recommended dosage of Zavzpret in 24 hours is 10 mg (one spray). It’s not known whether Zavzpret is safe to use for more than eight migraine episodes in a 30-day period.

Is Zavzpret used long term?

It’s possible, although Zavzpret is not used every day.

The drug is only used as needed to treat immediate symptoms of a migraine episode. Your doctor may recommend using Zavzpret as part of a long-term treatment plan for your condition.

To learn more about how long you may be prescribed Zavzpret, talk with your doctor.

To take a dose of Zavzpret, you’ll administer one spray into one nostril and then throw away the device. Each device is designed to deliver a single dose only. Do not test or prime the nasal spray before you use it, or you will lose your dose.

Your doctor or pharmacist can show you how to use Zavzpret. The manufacturer also provides these step-by-step instructions.

For information on the expiration, storage, and disposal of Zavzpret, talk with your doctor or pharmacist.

Accessible drug containers and labels

Some pharmacies provide medication labels that:

  • have large print
  • use braille
  • feature a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

Do not use more Zavzpret than your doctor prescribes, as this can lead to harmful effects.

What to do in case you use too much Zavzpret

Call your doctor right away if you think you’ve used too much Zavzpret. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Below are answers to some commonly asked questions about Zavzpret’s dosage.

Is Zavzpret’s dosage similar to the dosages of Imitrex or Nurtec ODT?

No. Although Zavzpret, sumatriptan (Imitrex), and rimegepant (Nurtec ODT) are all used to treat migraine episodes with or without an aura, their forms and dosages differ. Imitrex also belongs to a different group of drugs than Zavzpret and Nurtec ODT.

Zavzpret comes as a single-dose nasal spray that’s used as needed to treat migraine episodes.

Imitrex is also only used as needed. The drug comes as an oral tablet, nasal spray, and a liquid solution that’s injected under your skin.

Nurtec ODT is used to both prevent and treat migraine episodes. It comes as a tablet you dissolve under the tongue. The drug’s dosage depends on whether it’s being used to prevent or treat a migraine episode.

Your doctor will prescribe the drug and the dosage that’s right for you. To learn more about how these drugs compare, talk with your doctor.

How long does it take for Zavzpret to start working?

Zavzpret starts to work soon after you take a dose. You’ll likely notice your migraine symptoms easing within 2 hours of using Zavzpret.

Your doctor will monitor whether the drug is working to treat your migraine episodes. They’ll suggest other options if Zavzpret isn’t working or you have more than eight migraine episodes per 30 days. (It’s not known whether Zavzpret is safe to use more often than this.)

If you have other questions about what to expect from your Zavzpret treatment, talk with your doctor.

The sections above describe the usual dosage provided by the manufacturer. If your doctor recommends Zavzpret for you, they’ll prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Zavzpret without your doctor’s recommendation. Only use Zavzpret exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Examples of questions you may want to ask your doctor include:

  • Can I take a dose of Zavzpret and use another migraine medication in the same day?
  • How does the dosage of Zavzpret compare with that of ubrogepant (Ubrelvy)?
  • Will I need a dosage adjustment for Zavzpret if I have kidney problems?

To learn more about Zavzpret, see this article.

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.