Yupelri (revefenacin) is a prescription drug that’s used to treat chronic obstructive pulmonary disease (COPD). The drug comes as a liquid solution for inhalation with a jet nebulizer. It’s typically inhaled once per day.

Yupelri is prescribed for adults as a long-term treatment of chronic obstructive pulmonary disease (COPD). (It’s important to note that Yupelri is not used to treat sudden COPD flare-ups.)

The active ingredient in Yupelri is revefenacin. Yupelri belongs to a group of drugs called anticholinergic drugs.

This article describes Yupelri’s dosage, as well as its strength and how to use it. To learn more about Yupelri, see this in-depth article.

This section describes the usual dosage of Yupelri. Keep reading to learn more.

What is Yupelri’s form?

Yupelri is available as a liquid solution in single-dose vials. It’s used with a jet nebulizer. This device turns Yupelri solution into an aerosol mist that you breathe into your lungs.

What strength does Yupelri come in?

Yupelri comes in one strength of 175 micrograms (mcg) of medication per 3 milliliters (mL) of solution in unit dose vials.

What are the usual dosages of Yupelri?

The information below describes the dosage of Yupelri that’s commonly prescribed or recommended. But be sure to use the Yupelri dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs. In some cases, a doctor may adjust your dosage from those shown below.

Dosage for chronic obstructive pulmonary disease (COPD)

Yupelri is prescribed for adults to treat long-term symptoms of COPD.

The typical recommended Yupelri dosage is 175 mcg (one vial) inhaled once per day. You’ll use a jet nebulizer to take the medication. The nebulizer will turn Yupelri into a fine mist, which you’ll inhale through the mouthpiece attached to the nebulizer.

Do not swallow Yupelri. Use it only with a jet nebulizer to breathe in the medication.

You can see step-by-step directions from the manufacturer of Yupelri here on how to use the medication.

Talk with your doctor or pharmacist if you have questions about your dosage of Yupelri or how to use a nebulizer to take it.

Is Yupelri used long term?

Yes, Yupelri is usually prescribed as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.

Do not inhale more Yupelri than your doctor prescribes, as this can lead to harmful effects.

Symptoms of overdose

Symptoms caused by an overdose can include:

  • nausea/vomiting
  • dizziness
  • blurred vision or vision changes
  • eye pain or redness
  • obstipation (cannot pass stool or gas)

What to do in case you use too much Yupelri

Call your doctor right away if you think you’ve taken too much Yupelri. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Below are answers to some commonly asked questions about Yupelri’s dosage.

How does the dosage of Yupelri compare with other alternative drugs?

There are some differences in typical dosages between Yupelri and other similar drugs. Other medications available to treat COPD, such as Atrovent HFA (ipratropium bromide) or Brovana (arformoterol tartrate), have different active ingredients and dosages.

Atrovent HFA comes as a metered dose inhaler. It is a bronchodilator medication that works similarly to Yupelri and opens up your airways, allowing your lungs to work better and making breathing easier. The typical dosage of Atrovent HFA is 2 puffs taken four to six times per day.

Brovana is a different type of bronchodilator, but it still relaxes your airway muscles to allow you to breathe better. Both Yupelri and Brovana come as a liquid solution that’s used with a jet nebulizer to treat ongoing symptoms of COPD in adults, but their dosages differ. Yupelri is usually inhaled once per day while Brovana is usually inhaled twice per day.

Your doctor will prescribe the medication that best suits your needs. Talk with your doctor if you have other questions about Yupelri’s alternatives.

How long does it take Yupelri to start working?

Yupelri starts to work after your first dose. Because of how the drug works, you might not see improvements right away. But your doctor will monitor you during treatment to check whether the drug is working to treat your condition.

If you have other questions about what to expect from your Yupelri treatment, talk with your doctor.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.