Identifying the best medication for chronic pain depends on underlying causes and how severe your symptoms are.
Pain is a complex combination of psychological, social, and biological factors. This means it involves not just a physical response to injury but also the individual experiences and beliefs that shape how you perceive pain.
Pain can happen every day. Sometimes it’s temporary, like when you stub your toe. However, for many people, pain becomes a chronic challenge.
Chronic pain, which is generally considered to be pain that lasts longer than
Many medications can treat chronic pain, but the best options may change based on your circumstances. For instance, the cause of your chronic pain, whether due to injury or a medical condition, should be considered when choosing a treatment plan.
When you’re living with chronic pain, over-the-counter (OTC) medications are a common go-to. They’re accessible, fairly affordable, and available without a prescription because they have a good safety margin when taken as directed.
Pain medications are known as analgesics. OTC options for chronic pain include:
Also known as paracetamol (brand name Tylenol) around the world, acetaminophen’s exact method of pain reduction isn’t well understood.
It’s sometimes classified as a COX inhibitor because part of its known function is blocking, or inhibiting, cyclooxygenase (COX). This is an enzyme that the body uses in prostaglandin production, which generates pain perception.
Acetaminophen is one of the most widely used OTC pain medications available. It’s in hundreds of products, from cold medications to sleeping aids.
Though it’s marketed for pain, acetaminophen may be less effective compared with other OTC products. This is because it
Common side effects of acetaminophen use include:
- blistering, peeling, or red skin
- facial swelling
- swelling in the extremities
- difficulty swallowing or breathing
Nonsteroidal anti-inflammatory drugs (NSAIDs)
NSAIDs are true COX inhibitors. They work by inhibiting COX-1 or COX-2 enzymes (or both). In this way, they block pain perception, but they also help decrease inflammation.
Common OTC NSAIDs include:
Common side effects of NSAID use include:
- diarrhea or constipation
- swelling of the feet or ankles (edema)
- gastrointestinal bleeding or ulcers
- blood pressure increase
Topical OTC products are commonly used as supplements to other forms of long-term pain management, helping when the pain feels extra intense.
They can come as sprays, creams, ointments, or adhesive patches.
Common side effects of topical analgesics include:
- skin reddening
- burning sensation at the application site
When chronic pain is beyond OTC products, doctors have prescription-only options available. These include:
Stronger NSAIDs are available through your doctor. These include:
These medications work in the same ways as OTC NSAIDs but have a stronger effect. They may not be suitable for everyone, which is why they’re not available to the general public.
Medications that provide pain relief as a secondary benefit are known as adjuvants. These are drugs that have another primary purpose, like treating mental health disorders or calming muscle spasms.
Adjuvants are not used as monotherapy for chronic pain. This means they are not used on their own as a treatment for chronic pain. They may be added to your treatment plan at any stage to help cover a broader range of your pain symptoms when primary analgesics aren’t satisfactory.
Opioids are not the preferred option for chronic pain. Doctors prescribe them only when non-opioid medications aren’t effective. Even then, they’re prescribed at the smallest dosage to help decrease any risk of drug dependency.
Common opioids include:
Opioid side effects can be serious. They can include:
- slowed breathing
- drug dependency
According to the National Safety Council, emerging research suggests that opioids may no longer be the most effective way of managing severe chronic pain. Acetaminophen and NSAID combinations appear to provide a better level of pain management.
Acetaminophen is the most common OTC analgesic used in the United States. Each week, approximately 52 million people use an acetaminophen-containing product.
Among prescription options, the use of opioids for chronic pain remains prevalent. According to a 2021 National Health Statistics Report, in 2019,
There are many ways you can manage chronic pain, however. When it comes to the most common “treatment,” medication isn’t necessarily top of the list. In fact, many cases of chronic pain
Common non-medication approaches include:
So, what is the best medication for chronic pain? It depends on your symptoms, why you’re experiencing pain, how severe that pain is, and if you live with any conditions that might make certain drugs off-limits.
Acetaminophen and NSAIDs are common OTC products used to manage chronic pain. When they aren’t effective, your doctor can provide prescription options.
Many people assume opioids are the be-all-end-all when it comes to chronic pain management, but research suggests there are more effective treatment options that are less likely to cause dependence.