Tzield (teplizumab-mzwv) is a prescription drug used to help prevent worsening of type 1 diabetes. The drug comes as a liquid solution that’s given by intravenous (IV) infusion. It’s typically given once daily for 14 consecutive days.

Tzield is used in adults and certain children to help prevent type 1 diabetes from worsening to the point of causing symptoms besides high blood sugar.

The active ingredient in Tzield is teplizumab-mzwv.* An active ingredient is what makes a drug work. Tzield belongs to a group of drugs called biologics.

This article describes the dosages of Tzield, as well as its strengths and how it’s given. To learn more about Tzield, see this in-depth article.

* The reason “-mzwv” appears at the end of the drug’s name is to show that the drug is distinct from similar medications that may be created in the future.

This section describes the usual dosages of Tzield. Keep reading to learn more.

What is Tzield’s form?

Tzield is available as a liquid solution that’s given as an intravenous (IV) infusion (an injection into your vein over a period of time).

What strength does Tzield come in?

Tzield comes in one strength of 2 milligrams in 2 milliliters of solution (mg/mL).

What are the usual dosages of Tzield in adults?

Your doctor will likely start you on a low dosage and adjust it over time to reach the right amount for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The information below describes dosages that are commonly used or recommended. But your doctor will prescribe the right dosage to fit your needs.

Dosage for type 1 diabetes

The table below highlights the basics of Tzield’s dosage in adults. All doses are listed in micrograms per square meter of body surface area (mcg/m2).

Day 165 mcg/m2
Day 2125 mcg/m2
Day 3250 mcg/m2
Day 4500 mcg/m2
Days 5–141,030 mcg/m2

What’s the dosage of Tzield for children?

Tzield is used to help prevent the worsening of type 1 diabetes in children ages 8 years and older.

The dosage used in children is the same as the dosage for adults. To learn more, see the “What are the usual dosages of Tzield?” section above.

For more information about Tzield’s dosage for children, talk with your child’s doctor or a pharmacist.

Is Tzield used long term?

No, Tzield is not used as a long-term treatment. You’ll receive Tzield infusions once daily for 14 consecutive days.

Tzield comes as a liquid solution that’s given as an intravenous (IV) infusion (an injection into your vein over a period of time). You’ll receive infusions at your doctor’s office or a clinic. Each infusion lasts about 30 minutes.

For the first 5 days of treatment, your doctor will likely give you certain medications before you receive Tzield to help prevent reactions from the infusion.

If you have questions about what to expect at your appointments to receive Tzield infusions, talk with your doctor.

If you miss an appointment to receive a dose of Tzield, call your doctor’s office as soon as possible to discuss your dosing schedule. You will not receive two infusions on the same day to make up for a missed dose.

If you need help remembering your appointments, try setting an alarm or downloading a reminder app on your phone.

Below are answers to some commonly asked questions about Tzield’s dosage.

Is Tzield’s dosage similar to the dosages of Lantus?

The forms and how often doses are given are different. Tzield (teplizumab-mzwv) and Lantus (insulin glargine) both come as a liquid solution.

Tzield is given as an intravenous (IV) infusion* for 14 consecutive days. Lantus, on the other hand, is given as an injection under the skin once daily as a long-term treatment.

The dosage for each drug differs. Your doctor will prescribe the drug and the dosage that’s right for you.

To learn more about how these drugs compare, talk with your doctor.

* An IV infusion is an injection into a vein over a period of time.

How long does it take for Tzield to start working?

Tzield starts to work after your first dose. Because of how the drug works, you likely won’t feel the drug working in your body. But your doctor will monitor you during treatment to check whether the drug is working to treat your condition.

If you have other questions about what to expect from your Tzield treatment, talk with your doctor.

The sections above describe the usual dosage provided by the manufacturer. If your doctor recommends Tzield for you, they’ll prescribe the dosage that’s right for you.

Here are some examples of questions you may want to ask your doctor:

  • Does my dosage of Tzield need to be adjusted if I’m due to have a vaccine?
  • Should my dosage change if I experience side effects from Tzield?
  • If I develop an infection soon after starting Tzield, will you adjust my dosage?

To learn more about Tzield, see these articles:

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.