Tyrvaya (varenicline) is a prescription drug that’s used to treat dry eye disease in adults. The drug comes as a nasal spray. It’s typically used twice per day.

This section describes the usual dosages of Tyrvaya. Keep reading to learn more.

What is Tyrvaya’s form?

Tyrvaya comes as a nasal spray, with each package of the drug containing two nasal spray bottles. Each bottle of Tyrvaya contains 4.2 milliliters (mL) of medication.

What strength does Tyrvaya come in?

Tyrvaya comes in one strength of 0.03 milligrams (mg) per spray (0.05 mL) of the drug.

What are the usual dosages of Tyrvaya?

The information below describes dosages that are commonly used or recommended. But be sure to use the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs. In some cases, doctors may adjust your dosage from those shown below.

Dosage for dry eye disease

The typical Tyrvaya dosage for adults with dry eye disease is one spray into each nostril twice daily (about every 12 hours).

Tyrvaya comes as a nasal spray. Before using the nasal spray device for the first time, you’ll prepare the device by pumping seven sprays into the air. You should not shake the bottle. Be sure to spray away from your face. If you don’t use Tyrvaya for more than 5 days, you’ll need to prepare the device again by spraying it once into the air.

Once you start using a bottle of Tyrvaya, you should only use it for 30 days. After this time period, you should dispose of an open Tyrvaya bottle. It may be helpful to write the date on the bottle when you start using it.

Your doctor or pharmacist will show you exactly how to use Tyrvaya. You can view instructions in the drug’s prescribing information. The manufacturer also provides step-by-step instructions on how to use Tyrvaya.

Is Tyrvaya used long term?

Yes, Tyrvaya is typically used as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely use it long term.

What should I do if I miss a dose of Tyrvaya?

If you miss a dose of Tyrvaya, skip the missed dose and take your next dose at its regular time. You should not use two doses at once to make up for a missed dose. Doing so could raise your risk of side effects.

If you’re not sure whether you should take a missed dose or skip it, talk with your doctor or pharmacist. To help make sure you don’t miss a dose, try using a medication reminder. You could also download a reminder app on your phone.

Do not use more Tyrvaya than your doctor prescribes, as this can lead to harmful effects.

What to do in case you use too much Tyrvaya

Call your doctor right away if you think you’ve used too much Tyrvaya. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.