Trulicity (dulaglutide) and Mounjaro (tirzepatide) are prescribed to help manage blood sugar in people with type 2 diabetes. Trulicity also has other uses. Both drugs come as an injection that you give under the skin.

This article explains the main ways that Trulicity and Mounjaro are alike and different. For more information about these drugs, including details about their uses, see the in-depth articles on Trulicity and Mounjaro.

Get answers to some frequently asked questions about Trulicity and Mounjaro.

Is it safe to switch from Trulicity to Mounjaro?

It might be safe for some adults to switch, but not all. Trulicity and Mounjaro both are used to help manage blood sugar in adults who have type 2 diabetes. If you use Trulicity for this, it’s usually safe to switch to Mounjaro.

Trulicity is approved for the same use in children ages 10 years and older. But Mounjaro is not used in children. So it may not be safe for children to switch from Trulicity to Mounjaro.

Trulicity is also used to reduce the risk of heart attack and stroke in certain adults with type 2 diabetes. If you use Trulicity for this, it might not be safe to switch to Mounjaro. Mounjaro isn’t approved for this use, and it’s not known whether Mounjaro can reduce these risks.

If you’re interested in switching from Trulicity to Mounjaro, talk with your doctor. They can recommend whether switching is a safe option for you. If your doctor does recommend switching, they’ll likely have you start Mounjaro the week after your last dose of Trulicity.

How do Trulicity and Mounjaro compare with Ozempic?

Trulicity (dulaglutide), Mounjaro (tirzepatide), and Ozempic (semaglutide) are very similar medications. They’re all used to help manage blood sugar in adults with type 2 diabetes.

Trulicity and Ozempic also are used to reduce the risk of heart attack and stroke in certain adults who have type 2 diabetes. For this use in Trulicity, adults also must have heart disease or risk factors for it. (Risk factors include conditions such as high blood pressure or high cholesterol.) But for this use in Ozempic, adults must have heart disease, not just risk factors for it. Mounjaro is not used to reduce the risk of heart attack and stroke.

All three drugs come in prefilled single-dose injection pens. You inject them under your skin once per week. Mounjaro also comes in a single-dose vial for injection using the same dosage.

Trulicity and Ozempic belong to the same group of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. Mounjaro is similar to them but belongs to a different group of drugs. This group is dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists.

All three drugs can cause similar side effects.

To learn more about how these drugs compare, talk with your doctor.

Can Trulicity or Mounjaro be used for weight loss?

Trulicity and Mounjaro aren’t approved for weight loss. But in some cases, doctors may prescribe either of these drugs off-label for this purpose. (With off-label use, doctors prescribe a drug for a purpose other than what it’s approved to treat or help prevent.)

To learn more about using Trulicity or Mounjaro for weight loss, talk with your doctor. They can recommend the right treatment option for your condition.

See the list below to find out whether Trulicity or Mounjaro is available as a generic or biosimilar. (A generic drug contains an exact copy of the active ingredient in a brand-name medication. Biosimilars are like generic drugs. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.)

Trulicity is a biologic and Mounjaro is a nonbiologic.

  • Trulicity:
    • Available as a biosimilar: no
    • Active ingredient: dulaglutide
  • Mounjaro:
    • Available as a generic: no
    • Active ingredient: tirzepatide

See the table below for details on the approved uses for each drug.

UseTrulicityMounjaro
Help manage blood sugar levels in adults who have type 2 diabetes
Help manage blood sugar levels in children ages 10 years and older who have type 2 diabetes
Reduce the risk of heart attack and stroke in adults who have type 2 diabetes as well as heart disease or its risk factors

To learn more about using Trulicity or Mounjaro for your condition, talk with your doctor.

Trulicity or Mounjaro and children

Trulicity is used to help manage blood sugar in children ages 10 years and older who have type 2 diabetes. Mounjaro is not approved for use in children.

For more information about the use of Trulicity in children, talk with your child’s doctor.

The table below shows dosages of Trulicity and Mounjaro for the condition that both drugs treat.

Trulicity is also used to reduce the risk of heart attack and stroke in adults who have type 2 diabetes as well as heart disease or its risk factors. But this use isn’t addressed below. To learn more about dosages for all uses of both drugs, see the dosage articles for Trulicity and Mounjaro.

Dosage for type 2 diabetes

Doctors use the following dosages to help manage blood sugar in people who have type 2 diabetes. Strengths are in milligrams (mg) per milliliter (mL), shown as mg/mL.

TrulicityMounjaro
Who can use• adults
• children ages 10 years and older
• adults
Forms
(see below the table)
• prefilled single-dose injection pen• prefilled single-dose injection pen
• single-dose vial
Strengths• 0.75 mg/0.5 mL
• 1.5 mg/0.5 mL
• 3 mg/0.5 mL
• 4.5 mg/0.5 mL
• 2.5 mg/0.5 mL
• 5 mg/0.5 mL
• 7.5 mg/0.5 mL
• 10 mg /0.5 mL
• 12.5 mg/0.5 mL
• 15 mg/0.5 mL
Dosedepends on the treatment plan your doctor prescribes for youdepends on the treatment plan your doctor prescribes for you
How often to use once per week once per week

Both Trulicity and Mounjaro come as forms that you inject under the skin. A healthcare professional will teach you how to give the injections.

Trulicity and Mounjaro may cause side effects ranging from mild to serious.

For more information about possible side effects, see the side effect articles on Trulicity and Mounjaro.

Mild side effects

Trulicity and Mounjaro may cause mild side effects. The table below lists examples of mild side effects that have been reported with these drugs.

Mild side effectsTrulicityMounjaro
nausea and vomiting
constipation
diarrhea
pain in the abdomen
bloating in the abdomen
indigestion
reduced appetite
weight loss
burping or gas
fatigue (low energy)
increased heart rate
injection site reaction

This table may not include all mild side effects of these drugs. For more information on the mild side effects of the two drugs, see the Trulicity prescribing information and Mounjaro prescribing information.

Serious side effects

In addition to the mild side effects described above, serious side effects may occur in people using Trulicity or Mounjaro. The table below lists serious side effects that have been reported with these drugs.

Serious side effects TrulicityMounjaro
gallbladder problems, such as gallstones
inflammation of the pancreas (pancreatitis)
allergic reaction
low blood sugar level
severe digestion side effects
kidney problems

Trulicity and Mounjaro have a boxed warning for possible risk of thyroid cancer. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). For more information, see the “What are the warnings for Trulicity and Mounjaro?” section below.

To learn about your specific risk of serious side effects from Trulicity or Mounjaro, talk with your doctor or pharmacist.

You may wonder whether Trulicity or Mounjaro is effective for your condition.

Trulicity and Mounjaro both help manage blood sugar in adults who have type 2 diabetes. Studies of Trulicity and Mounjaro have shown that these drugs are effective for this use. In addition, the American Diabetes Association includes both drugs in its treatment recommendations for type 2 diabetes.

It’s important to note that your results from Trulicity or Mounjaro may differ from those seen in studies. Talk with your doctor about whether one of these drugs is right for you.

If you’d like to read more about how each drug performed in studies, see the Trulicity prescribing information and Mounjaro prescribing information.

Whether or not you have health insurance, cost may be a factor when you’re considering these drugs. See the price estimates for Trulicity and Mounjaro when you use coupons from the Optum Perks site. (Optum Perks is a sister site of Healthline.) It’s important to note that Optum Perks coupons cannot be used with any insurance copays or benefits.

Keep in mind that what you’ll pay for either drug will depend on several factors. These include:

  • your treatment plan
  • your health insurance
  • the pharmacy you use

For other resources that might help you save on the price of these drugs, see the articles about cost for Trulicity and Mounjaro.

Trulicity and Mounjaro may not be right for you if you have certain medical conditions or other factors that affect your health. These may be referred to as warnings.

The two drugs share some of the same warnings, but they also have different ones. Some of these warnings are mentioned below. Before you start using Trulicity or Mounjaro, be sure to talk with your doctor to learn whether these warnings apply to you.

Boxed warning: Risk of thyroid cancer

Trulicity and Mounjaro both have a boxed warning. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about drug effects that may be dangerous.

Dulaglutide (the active drug in Trulicity) and tirzepatide (the active drug in Mounjaro) can increase the risk of thyroid tumors in animals. It’s not known whether these drugs can increase the risk of thyroid cancer in people.

Due to the possible risk in humans, your doctor likely won’t prescribe Trulicity or Mounjaro if:

During treatment with Trulicity or Mounjaro, you should see your doctor if you develop symptoms of thyroid cancer. These can include:

  • a lump in your neck
  • hoarseness that doesn’t go away
  • difficulty swallowing or breathing

To learn more about the risk of thyroid cancer with these drugs, talk with your doctor or pharmacist.

Other warnings

In addition to their boxed warnings, Trulicity and Mounjaro have other warnings.

Before using Trulicity or Mounjaro, talk with your doctor if any of the following conditions or health factors apply to you.

To learn more about these drugs, see the in-depth articles on Trulicity and Mounjaro.

If you have type 2 diabetes, Trulicity and Mounjaro are two treatment options that may help manage your blood sugar. The way you use these drugs and some of their side effects are similar.

If you also have heart disease or its risk factors, Trulicity can help reduce your heart attack and stroke risk.

Talk with your doctor if you have any questions about these drugs. They can recommend the best treatment option for you. Examples of questions you may want to ask your doctor include:

  • Do either of these drugs interact with my other medications?
  • Do these medications need to be stored differently?
  • Have either of these drugs been studied in pregnancy?

To learn more about Trulicity or Mounjaro, see these articles:

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.