Trulance (plecanatide) is a prescription oral tablet used in adults to treat constipation due to certain conditions. This drug isn’t known to interact with other medications, but it can interact with certain health conditions.
An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.
Trulance is not known to interact with other medications. However, this doesn’t mean drug interactions can’t happen or won’t be identified later.
Before you start taking Trulance, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions that may be discovered later. (To learn whether Trulance interacts with herbs or vitamins and supplements, see the “Are there other interactions with Trulance?” section below.)
If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.
Certain health conditions or other factors could raise your risk of harm if you take Trulance. In such cases, your doctor may not prescribe Trulance for you. These are known as contraindications. The list below includes contraindications of Trulance.
Children under age 6 years: Trulance has a boxed warning about the risk for serious dehydration in children. Due to this risk, the drug should not be used in children under age 6 years. To learn more, see the “Boxed warning” section at the beginning of this article.
If you have a known or suspected obstruction in your bowels: You should not take Trulance if you have a known or suspected obstruction (blockage) in your bowels. The drug will not relieve constipation related to a bowel obstruction. Instead, your doctor can recommend a different treatment for your condition.
Before you start taking Trulance, talk with your doctor if either of the factors above applies to you. Your doctor can determine whether Trulance is safe for you to take.
Trulance is not known to interact with alcohol. But Trulance and alcohol can cause some similar side effects, such as diarrhea and dizziness. So you may be more likely to experience these side effects if you drink alcohol during your Trulance treatment.
If you have questions about consuming alcohol while using Trulance, talk with your doctor or pharmacist.
Trulance may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Trulance.
Does Trulance interact with supplements?
Before you start using Trulance, talk with your doctor and pharmacist about any herbs or vitamins and supplements you take. Sharing this information with them may help you avoid possible interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Trulance and herbs
There are currently no reports of Trulance interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.
For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Trulance.
Trulance and vitamins
There are currently no reports of Trulance interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.
For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Trulance.
Does Trulance interact with food?
There are currently no reports of Trulance interacting with food. If you have questions about eating certain foods during your treatment with Trulance, talk with your doctor.
Does Trulance interact with vaccines or lab tests?
There are currently no reports of Trulance interacting with vaccines or lab tests. If you have questions about receiving certain vaccines or having lab tests done during your Trulance treatment, talk with your doctor.
Does Trulance interact with cannabis or CBD?There are currently no reports of Trulance interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Trulance.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Certain medical conditions or other health factors may raise the risk of interactions with Trulance. Before taking Trulance, talk with your doctor about your health history. They’ll determine whether Trulance is right for you.
Health conditions or other factors that might interact with Trulance include:
Known or suspected obstruction in your bowels: You should not take Trulance if you have a known or suspected obstruction in your bowels. The drug will not relieve constipation related to a bowel obstruction. Instead, your doctor can recommend a different treatment for your condition.
Pregnancy: It’s not known whether Trulance is safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before taking Trulance.
Breastfeeding: It may be safe to take Trulance while breastfeeding. The drug is not known to pass into breast milk, and it isn’t expected to cause side effects in a child who is breastfed. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.
Allergic reaction: If you’ve had an allergic reaction to Trulance or any of its ingredients, your doctor will likely not prescribe Trulance. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.
Find answers to some frequently asked questions about Trulance and possible interactions.
Can you take laxatives with Trulance?
Yes, if your doctor tells you that it’s safe to do so. There are no known interactions between Trulance and laxatives. Both of these medications are used to treat constipation.
There are several types of laxatives available, and your doctor can provide more information on whether one may be useful for treating your condition. They can also advise you on whether your constipation may respond to laxatives, Trulance, or both.
Keep in mind that laxatives can cause similar side effects to Trulance, including diarrhea. Combining these medications may increase your risk for certain side effects or increase the risk that these side effects will be serious if they occur.
How do Trulance’s interactions compare to those of Linzess?
Trulance and Linzess are both prescribed for adults to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). (Unlike Trulance, Linzess may also be prescribed to treat functional constipation in children ages 6 to 17 years. Trulance should not be used in children.)
Based on studies of Trulance and Linzess, neither drug is known to interact with other medications. But it’s possible that interactions for either medication could be discovered in the future.
If you have other questions about how Trulance and Linzess compare, talk with your doctor or pharmacist. You can also see this article to learn more.
Taking certain steps can help you avoid interactions with Trulance. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:
- whether you drink alcohol or use cannabis
- other medications you take, as well as any vitamins, supplements, and herbs (they can also help you fill out a
medication list ) - what to do if you start taking a new drug during your Trulance treatment
It’s also important to understand Trulance’s
If you have trouble reading or understanding this information, your doctor or pharmacist can help.
Taking Trulance exactly as prescribed can also help prevent interactions.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.