Trodelvy (sacituzumab govitecan-hziy) is a prescription drug used to treat certain kinds of breast cancer and bladder cancer. This drug can interact with some other medications. For example, Trodelvy can interact with certain other cancer treatments.
You’ll receive Trodelvy as an intravenous (IV) infusion given by a healthcare professional. (An IV infusion is an injection into a vein given over a period of time.)
An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.
Keep reading to learn about Trodelvy’s possible interactions. And for more information about Trodelvy, including details about its uses, see this article.
* The reason “-hziy” appears at the end of the drug’s name is to show that the drug is distinct from similar medications that may be created in the future.
Before you start Trodelvy treatment, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Trodelvy interacts with supplements, herbs, and vitamins, see the “Are there other interactions with Trodelvy?” section below.)
If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.
The table below lists drugs that may interact with Trodelvy. Keep in mind that this table does not include all drugs that may interact with Trodelvy. For more information about some of these interactions, see the “Drug interactions explained” section below.
| Drug group or drug name | Drug examples | What can happen |
| certain tyrosine kinase inhibitors | • erlotinib • nilotinib (Tasigna) • regorafenib (Stivarga) • sorafenib (Nexavar) | can increase the risk of side effects from Trodelvy |
| certain protease inhibitors for HIV | • atazanavir (Reyataz) • ritonavir (Norvir) | can increase the risk of side effects from Trodelvy or make Trodelvy less effective |
| certain seizure medications | • carbamazepine (Tegretol, Equetro, others) • phenytoin (Dilantin, Phenytek) | can make Trodelvy less effective |
| rifampin (Rifadin, Rimactane) | – | can make Trodelvy less effective |
| ketoconazole | – | can increase the risk of side effects from Trodelvy |
Certain health conditions or other factors could raise your risk of harm if you take Trodelvy. In such cases, your doctor may not prescribe Trodelvy for you. These are known as contraindications. Trodelvy has one contraindication, which is described below.
If you’ve had a severe allergic reaction. If you have had a severe allergic reaction to Trodelvy or any of its ingredients, your doctor likely won’t prescribe Trodelvy. This is because receiving the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.
Before you start Trodelvy treatment, talk with your doctor if any of the factors above apply to you. Your doctor can determine whether Trodelvy is safe for you to use.
Trodelvy is not known to interact with alcohol. But Trodelvy and alcohol can cause some similar side effects, such as diarrhea*, nausea, and vomiting. You may be more likely to experience these side effects if you drink alcohol during your Trodelvy treatment.
If you have questions about consuming alcohol during Trodelvy treatment, talk with your doctor or pharmacist.
* Trodelvy can cause severe diarrhea in some people. In fact, the drug has a
Learn more about certain drug interactions that can occur with Trodelvy.
Interaction with certain tyrosine kinase inhibitors
Trodelvy can interact with certain tyrosine kinase inhibitors (TKIs), which are used to treat certain types of cancer.
Examples of TKIs include:
What could happen
Certain TKIs lower the activity of an enzyme (protein) in your liver called UGT1A1. This enzyme usually helps remove Trodelvy from your body.
Combining Trodelvy with one of these TKIs could make Trodelvy levels build up in your body. This can raise your risk of side effects of Trodelvy, such as diarrhea* and neutropenia* (low level of white blood cells).
If you carry a gene for uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1)*28, you may have a higher risk of this interaction.
* Trodelvy has a
What you can do
Due to this interaction, your doctor will likely avoid prescribing Trodelvy with TKIs that are UGT1A1 inhibitors.
If you take Trodelvy and a TKI together, tell your doctor right away if you have diarrhea or symptoms of neutropenia. These symptoms may include:
- fever
- chills
- sweating
- mouth sores
- sore throat
- cough
If you have questions about using Trodelvy with a TKI, talk with your doctor or pharmacist.
Interaction with certain seizure medications
Trodelvy can interact with certain seizure medications, which are used to treat epilepsy or seizures related to other conditions. Doctors also prescribe these drugs for bipolar disorder and certain types of nerve pain.
The following seizure medications can interact with Trodelvy:
- carbamazepine (Tegretol, Equetro, others)
- phenytoin (Dilantin, Phenytek)
What could happen
Carbamazepine and phenytoin can increase the activity of an enzyme in your liver called UGT1A1. This enzyme helps remove Trodelvy from your body.
Combining Trodelvy with carbamazepine or phenytoin could lower the amount of Trodelvy in your body. This could make Trodelvy less effective.
What you can do
Due to this interaction, your doctor will likely avoid prescribing Trodelvy with carbamazepine or phenytoin. Talk with your doctor about other treatment options for your condition.
Trodelvy may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Trodelvy.
Does Trodelvy interact with supplements?
Before you start Trodelvy treatment, talk with your doctor and pharmacist about any supplements, herbs, and vitamins you take. Sharing this information with them may help you avoid possible interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Trodelvy and herbs or vitamins
There are currently no reports of Trodelvy interacting with herbs or vitamins. But this doesn’t mean that such interactions won’t be recognized in the future.
For this reason, it’s still important to check with your doctor or pharmacist before using any of these products during your Trodelvy treatment.
Does Trodelvy interact with food?
There are currently no reports of Trodelvy interacting with food. If you have questions about eating certain foods during your treatment with Trodelvy, talk with your doctor.
Does Trodelvy interact with vaccines?
Your doctor may recommend that you do not receive live vaccines* during your Trodelvy treatment. This is because Trodelvy can cause neutropenia (low level of white blood cells), which can raise your risk of infection. Trodelvy has a
Getting a live vaccine during Trodelvy treatment could cause serious infection. Examples of live vaccines include measles, mumps, rubella (MMR), rotavirus, and chickenpox. If you need to receive a vaccine, talk with your doctor first to make sure it’s safe.
* Live vaccines contain weakened versions of the bacteria or virus that they’re meant to protect against.
Does Trodelvy interact with lab tests?
There are currently no reports of Trodelvy interacting with lab tests. If you have questions about having certain lab tests during your treatment with Trodelvy, talk with the healthcare professional ordering the test.
Does Trodelvy interact with cannabis or CBD?There are currently no reports of Trodelvy interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Trodelvy.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Certain medical conditions or other health factors may raise the risk of interactions with Trodelvy. Before starting Trodelvy treatment, talk with your doctor about your health history. They’ll determine whether Trodelvy is right for you.
Health conditions or other factors that might interact with Trodelvy include:
Liver problems. If you have a moderate or severe liver problem, your doctor may not prescribe Trodelvy for you. This is because it’s not known whether Trodelvy will be safe or effective for you. Your doctor will likely check your liver function before prescribing Trodelvy.
Having the UGT1A1*28 gene. If you carry a gene for uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1)*28, you may have a higher risk of certain side effects with Trodelvy. These side effects include anemia, neutropenia,* and a severe kind of neutropenia called febrile neutropenia. Your doctor may test you for the UGT1A1*28 gene before prescribing Trodelvy for you. If you carry this gene, talk with your doctor about whether Trodelvy is right for you.
Pregnancy. Trodelvy is not safe to receive during pregnancy. If you’re pregnant or planning to become pregnant, talk with your doctor about other treatments that may be better choices for you.
If you’re sexually active and you or your partner could become pregnant, talk with your doctor about your birth control needs during your Trodelvy treatment.
Breastfeeding. It’s not safe to breastfeed during Trodelvy treatment. You should wait at least 1 month after your last dose of Trodelvy before breastfeeding.
It’s not known whether Trodelvy passes into breast milk. But if it does, it could cause side effects in a child who’s breastfed. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.
Allergic reaction. If you’ve had an allergic reaction to Trodelvy or any of its ingredients, your doctor will likely not prescribe Trodelvy. This is because receiving the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.
* Trodelvy has a
Taking certain steps can help you avoid interactions with Trodelvy. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:
- Whether you drink alcohol or use cannabis.
- Other medications you take, as well as any vitamins, supplements, and herbs. Your doctor or pharmacist can help you fill out a
medication list . - What to do if you start taking a new drug during your Trodelvy treatment.
If you still have questions about Trodelvy and its possible interactions, talk with your doctor.
Questions you may want to ask your doctor include:
- Do I carry the UGT1A1*28 gene? If so, will I be monitored more closely during Trodelvy treatment?
- Do I need to tell you if I start another medication or supplement during my Trodelvy treatment?
- Do other drugs that could treat my cancer have similar interactions to Trodelvy?
To learn more about Trodelvy, see these articles:
- Trodelvy (sacituzumab govitecan-hziy)
- Side Effects of Trodelvy: What You Need to Know
- Dosage for Trodelvy: What You Need to Know
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.