If you have a certain kind of cancer, your doctor might suggest Tibsovo as a treatment option for you.

Tibsovo is a prescription medication that’s used in some adults to treat certain kinds of the following cancers:

For example, the cancer being treated must have a specific gene mutation.

Tibsovo comes as a tablet that you swallow, and its active ingredient is ivosidenib. An active ingredient is what makes a drug work.

This article describes the dosages of Tibsovo, as well as its strength and how to take it. To learn more about Tibsovo, including details about the cancers it’s used to treat, see this in-depth article.

Note: The chart below highlights Tibsovo’s dosage basics. Be sure to read on for more details. And keep in mind that this article covers Tibsovo’s standard dosage schedule, which is provided by the drug’s manufacturer. But always follow the dosing instructions your doctor prescribes.

Tibsovo formTibsovo strengthUsual dosage
oral tablet250 milligrams (mg) per tablet500 mg once per day

This section describes common dosage information for Tibsovo. Before you start taking this medication, your doctor will discuss dosing instructions specific to your condition. Always take the dosage of Tibsovo that your doctor recommends for you.

What is Tibsovo’s form?

Tibsovo comes as a tablet that you swallow.

What strength does Tibsovo come in?

Tibsovo comes in one strength: 250 milligrams (mg).

What are the usual dosages of Tibsovo?

Your doctor will usually start you on the recommended dosage of Tibsovo. They may adjust your dosage over time to reach the right amount for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The information below describes dosages that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosage for acute myeloid leukemia

The recommended dosage of Tibsovo for acute myeloid leukemia (AML) is 500 mg (two 250-mg tablets) taken by mouth once per day.

Dosage for bile duct cancer

The recommended dose of Tibsovo for bile duct cancer is 500 mg (two 250-mg tablets) taken by mouth once per day.

Is Tibsovo used long term?

Yes, Tibsovo is usually taken as a long-term treatment. If you and your doctor determine that Tibsovo is safe and effective for you, you’ll likely use it long term.

If you’re taking Tibsovo for AML, your doctor will recommend taking it for at least 6 months to see if the drug is working for you. The manufacturer does not provide a similar recommendation for bile duct cancer treatment with Tibsovo.

For either condition, your doctor may have you stop Tibsovo treatment if you have severe side effects from it or the cancer worsens.

Dosage adjustments

In some cases, your doctor may recommend a lower dosage of Tibsovo than what’s usually prescribed.

For example, some medications may increase the amount of Tibsovo in the body. This can increase the risk of side effects. If you take medications that can interact with Tibsovo this way, your doctor may recommend a Tibsovo dose decrease.

In addition, if you have certain side effects from Tibsovo, your doctor may recommend decreasing your dose of Tibsovo. This includes long QT syndrome, which is a heart rhythm problem, and any other side effects that are serious.

If you have questions about the best dosage of Tibsovo for you, talk with your doctor.

The dosage of Tibsovo you’re prescribed may depend on several factors. These include:

  • side effects that you have from taking Tibsovo
  • other medications that you take (see “Dosage adjustments” under “What is Tibsovo’s dosage?”)

You’ll take your dose of Tibsovo by mouth once daily. You can take your dose with or without food, but avoid taking it with a high-fat meal. This can cause too much of the drug to be released in your body right away, increasing your risk of side effects.

You should take your dose of Tibsovo as a whole tablet. Do not break, crush, or chew the tablets.

If you vomit after taking Tibsovo, do not take another dose. Instead, take your next dose at your usually scheduled time the next day.

For information on Tibsovo expiration, storage, and disposal, see this article.

Accessible drug containers and labels

If you find it hard to read the prescription label on your medication, tell your doctor or pharmacist. Some pharmacies may provide medication labels that:

  • have large print or use braille
  • feature a code that you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

If you have trouble opening medication bottles, let your pharmacist know. They may be able to supply Tibsovo in an easy-open container. Your pharmacist may also have some tips that can help make it simpler to open the drug’s container.

If you miss a dose of Tibsovo, whether you should take a dose right away depends on when you remember. If it’s at least 12 hours before the usually scheduled time for your next dose, take the missed dose. Otherwise, wait until the usually scheduled time to take a dose. Never take two doses of Tibsovo within 12 hours.

If you missed a dose of Tibsovo and you’re unsure when to take your next dose, talk with your doctor or pharmacist. They can recommend when you should take your next dose of medication.

If you need help remembering to take your dose of Tibsovo on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Do not use more Tibsovo than your doctor prescribes. Using more than this can lead to serious side effects.

What to do in case you take too much Tibsovo

Call your doctor right away if you think you’ve taken too much Tibsovo. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

The sections above describe the usual dosages provided by the drug’s manufacturer. If your doctor recommends Tibsovo for you, they’ll prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Tibsovo without your doctor’s recommendation. Only take Tibsovo exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • Will my other medications affect my Tibsovo dosage?
  • Can you decrease my dosage of Tibsovo if I’m having bothersome side effects from the medication?
  • Will my other medical conditions affect my dosage of Tibsovo?


If Tibsovo isn’t working for me, can I try a higher dosage of the drug?



If Tibsovo doesn’t seem to be working to treat your cancer, your doctor will not increase your dosage of Tibsovo. Increasing the dosage will not cause the cancer to start responding to the drug. But a higher dosage could increase your risk of side effects.

If you’re taking Tibsovo and the drug doesn’t seem to be working for you, your doctor will likely suggest that you stop taking the drug. In this case, they’ll recommend a new treatment option for you that may work to treat your cancer.

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.