If you have type 2 diabetes, your doctor might suggest Soliqua 100/33 as a treatment option for you.

Soliqua 100/33 is a prescription medication that’s used to treat type 2 diabetes in adults. You should use this medication along with diet and exercise to treat your diabetes. Soliqua 100/33 should not be used to treat type 1 diabetes.

This medication is a combination of two drugs: insulin glargine and lixisenatide. Insulin glargine is a type of insulin that helps lower blood sugar. Lixisenatide belongs to a group of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists, which also work to treat diabetes.

Soliqua 100/33 comes as a solution that’s injected under your skin.

This article describes the dosages of Soliqua 100/33, including its form, strength, and how to use the drug. To learn more about Soliqua 100/33, see this in-depth article.

Note: This article covers typical dosages of Soliqua 100/33, which are provided by the drug’s manufacturer. But when using Soliqua 100/33, always take the dosage that your doctor prescribes.

Below are common dosages for Soliqua 100/33. But your doctor will determine the best dosage of this drug for you. Always be sure to follow the dosage your doctor prescribes.

What is the form for Soliqua 100/33?

Soliqua 100/33 is available as a solution that’s injected under your skin. It comes in an injection pen that contains 3 milliliters (mL) of liquid solution.

What strength does Soliqua 100/33 come in?

Soliqua 100/33 is available in only one strength. It contains 100 units of insulin glargine and 33 micrograms (mcg) of lixisenatide in each mL of solution.

What are the typical dosages of Soliqua 100/33?

Typically, your doctor will start you on a low dosage. Then, they’ll adjust your dosage over time to reach the right amount for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The information below describes dosages that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

In some cases, your doctor may recommend a starting dose of 15 units of Soliqua 100/33. (This is 15 units of insulin glargine and 5 mcg of lixisenatide.) This will likely be your starting dose of Soliqua 100/33 if:

  • you’ve never taken insulin or other GLP-1 receptor agonists (such as lixisenatide), or
  • you’re taking fewer than 30 units of basal insulin per day

If you’re already taking 30 to 60 units of basal insulin daily, your doctor may recommend a dosing conversion to Soliqua 100/33. They’ll likely suggest that you take 30 units of Soliqua 100/33 (30 units of insulin glargine and 10 mcg of lixisenatide) once daily.

You should take your dose within an hour before your first meal of the day. You only need to inject this medication once daily.

After you take this starting dose for a week, your doctor may change your dose based on your blood sugar level. Your dose may change each week by 2 to 4 units, depending on your glucose levels.

If you have any changes in your diet or physical activity, be sure to tell your doctor. This can also affect your blood sugar, and you may need more or less Soliqua 100/33.

Dosing chart for Soliqua 100/33

Past treatmentsStarting dose of Soliqua 100/33Dose of insulin glargineDose of lixisenatideDose changes, if needed
if you’ve never taken insulin or GLP-1 agonists15 units15 units5 mcg+/– 2 to 4 units each week, if needed
if you’re taking fewer than 30 units of basal insulin daily15 units15 units5 mcg+/– 2 to 4 units each week, if needed
if you’re taking 30 to 60 units of basal insulin per day30 units30 units10 mcg+/– 2 to 4 units each week, if needed

What is the maximum dose for Soliqua 100/33?

The maximum dose for Soliqua 100/33 is 60 units per day. This dose delivers 20 mcg of lixisenatide.

Is Soliqua 100/33 used long term?

Yes, Soliqua 100/33 is typically used as a long-term treatment. If you and your doctor decide that Soliqua 100/33 is safe and effective for you, you’ll likely use it long term.

Dosage adjustments

In some cases, your doctor may recommend a different dosage for you, such as if you:

In these cases, your doctor may recommend a different starting or maintenance dose for you. Talk with your doctor about the best dosage for you.

The dosage of Soliqua 100/33 you’re prescribed may depend on several factors. These include:

  • the severity of the condition you’re using Soliqua 100/33 to treat
  • other medications that you’re taking
  • other conditions you may have (see “Dosage adjustments” under “What is the dosage for Soliqua 100/33?”)

Before you start Soliqua 100/33, your doctor or pharmacist will teach you how to take this drug. Soliqua 100/33 is a solution that’s injected under your skin once daily. You can inject it into your stomach area, thigh, or upper arm.

You should not inject Soliqua 100/33 into the same area each time. Instead, you should change injection sites to lower your risk of skin-related side effects. Also, you should not inject your dose into skin that’s bruised, hard, scarred, or tender. Always use a new needle for injecting your dose of Soliqua 100/33.

For a step-by-step video or instructions on how to inject Soliqua 100/33, see the manufacturer’s website.

If you miss your dose of Soliqua 100/33, skip the missed dose and inject your usual dose the next day. Never take more than one dose to try to make up for a missed dose. If you have questions about missed doses, talk with your doctor or pharmacist.

If you need help remembering to take your dose of Soliqua 100/33 on time, try using a medication reminder. These include setting an alarm or downloading a reminder app on your phone.

Don’t use more Soliqua 100/33 than your doctor prescribes. Using more than this can lead to serious side effects.

Symptoms of overdose

An overdose of insulin glargine can cause symptoms of low blood sugar, which may include:

Overdose symptoms from lixisenatide (the other active drug in Soliqua 100/33) may include stomach problems.

What to do in case you use too much Soliqua 100/33

Call your doctor right away if you think you’ve used too much Soliqua 100/33. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or you can use its online resource. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

The sections above describe the typical dosages provided by the drug’s manufacturer. If your doctor recommends Soliqua 100/33 for you, they’ll prescribe the dosage that’s right for you.

Remember, you shouldn’t change your dosage of Soliqua 100/33 without your doctor’s recommendation. Only use Soliqua 100/33 exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • How can you change my dosage of Soliqua 100/33 so that it’s working best for me?
  • Does a higher dosage increase my risk of side effects from this drug?
  • Does my dosage of Soliqua 100/33 need to change if I’m also taking other medications for my diabetes?
  • If Soliqua 100/33 isn’t working for me, can you increase my dose?

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If I’m experiencing side effects from Soliqua 100/33, can you decrease my dose?



If you’re experiencing side effects, decreasing your dosage is one thing your doctor may recommend.

If you’re having side effects from Soliqua 100/33, be sure to let your doctor know. They’ll want to ask questions about your side effects, and they’ll likely ask other questions about your diabetes and general health.

Depending on your side effects, your doctor may order lab tests to get a more complete picture of your health. This includes your blood sugar levels and how well Soliqua is working to keep them where they should be. Your doctor can then discuss options for treating your side effects, which may include decreasing your Soliqua dose.

Remember, never change your Soliqua dose unless your doctor specifically tells you to. Always take the exact dose as prescribed by your doctor.

Alex Brewer, PharmD, MBAAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.