If you have a certain kind of psoriasis, your doctor might suggest Siliq as a treatment option. It’s a prescription drug used to treat moderate to severe plaque psoriasis in adults.

Siliq’s active ingredient is brodalumab. (An active ingredient is what makes a drug work.) Brodalumab is a biologic drug, which means it’s made in a laboratory from living cells. It belongs to a group of drugs called interleukin-17 receptor antagonists.

Siliq comes as a liquid solution in a prefilled syringe that you or your doctor inject under your skin.

This article describes the dosage of Siliq, as well as its strength and how to use it. To learn more about Siliq, see this in-depth article.

Note: This chart highlights the basics of Siliq’s dosage. Be sure to read on for more detail. And keep in mind that this article covers Siliq’s standard dosage schedule, which is provided by the drug’s manufacturer. But always follow the dosing instructions your doctor prescribes.

Recommended Siliq starting doseRecommended Siliq maintenance dose
210 milligrams (mg) once per week for 3 weeks210 mg once every 2 weeks

This section covers standard Siliq dosing and administration information. Before you start this drug, your doctor will discuss dosing details specific to your needs.

What is Siliq’s form?

Siliq comes as a liquid solution in a single-dose, prefilled syringe that you or your doctor inject under your skin.

What strengths does Siliq come in?

Siliq syringes come in one strength of 210 milligrams (mg) per 1.5 milliliters (ml) of liquid.

What are the usual dosages of Siliq?

The information below describes dosages that are commonly used or recommended. But be sure to follow the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Usually, your doctor will prescribe a loading (starting dose). You’ll inject this starting dose for the first 3 weeks. Then you’ll give yourself a maintenance dose, which is the same dose of Siliq injected less often.

The following is a recommended dosing schedule for Siliq:

  • 210 mg once per week for 3 weeks, then
  • 210 mg once every 2 weeks

Is Siliq used long term?

Your doctor will decide how long you’ll use Siliq based on how your psoriasis responds to it. If you and your doctor determine that Siliq is safe and effective for you, you’ll likely use it long term.

After 12 to 16 weeks of treatment, your doctor will evaluate how well Siliq is working. If the medication is not helping with your condition, your doctor may have you stop using it and try a different medication.

If you miss a dose of Siliq, inject it as soon as you remember. But if it’s almost time for your next dose, call your doctor or pharmacist. They’ll let you know if you should inject the missed dose or skip it.

If you need help remembering to inject your dose of Siliq on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Siliq comes as a liquid solution in a single-dose, prefilled syringe that you or your doctor inject under your skin. You’ll likely receive your first injection from a healthcare professional in a doctor’s office or clinic. Once they’ve shown you how to do it, you can give yourself the injections at home.

You may inject Siliq into the following areas:

  • the outer area of your upper arm (if someone else is giving you the injection)
  • your stomach area, avoiding the area 2 inches (in) around your belly button
  • your thigh

It’s recommended that you rotate injection sites each time you inject a dose.

For detailed instructions and videos on how to inject this drug, visit the manufacturer’s website.

For information on Siliq expiration, storage, and disposal, see this article.

Accessible drug containers and labels

If you find it hard to read the prescription label on your medication, tell your doctor or pharmacist. Some pharmacies may provide medication labels that:

  • have large print or use braille
  • feature a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

Do not inject more Siliq than your doctor prescribes, as this can lead to serious side effects.

What to do in case you inject too much Siliq

Call your doctor right away if you think you’ve injected too much Siliq. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource. If you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Below are answers to some common questions about Siliq’s dosage.

Can I hold my Siliq prefilled syringe in my palm to warm it up?

No, you should avoid using any heat source to bring your Siliq syringe to room temperature. To warm this medication, leave it out of the refrigerator for 30 minutes before injecting it. Do not leave it in direct sunlight or use hot water or a microwave oven to warm it.

Is there a children’s dosage for Siliq?

There is no children’s dosage for Siliq. This drug is approved by the Food and Drug Administration (FDA) to treat plaque psoriasis in adults only.

The sections above describe the usual dosages provided by the drug’s manufacturer. If your doctor recommends Siliq for you, they’ll prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Siliq without your doctor’s recommendation. Only use Siliq exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage. Here are some examples of questions you may want to ask them:

  • Would a different Siliq dosage increase my risk of side effects from Siliq?
  • Will you change my Siliq dosage if I have liver problems?
  • Would I need to stop Siliq if I developed an infection?

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Why would I need to stop using Siliq after 12 to 16 weeks of treatment?



Due to the risk of suicidal thoughts and behavior*, Siliq’s manufacturer doesn’t recommend continuing treatment for longer than 12 to 16 weeks if Siliq isn’t working. It was found in studies that the drug was unlikely to work if symptoms had not eased in this timeframe.

Let your doctor know if you don’t see a reduction in your symptoms after 16 weeks of treatment with Siliq. They may have you stop the drug and will recommend an alternative treatment.

* Siliq has a boxed warning for the risk of suicidal thoughts and behavior. For more information about this warning, see the “Boxed warning section” at the beginning of the article.

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.