Rydapt (midostaurin) is a prescription oral capsule that’s used to treat certain cancers. This drug can interact with other medications and some supplements. For example, Rydapt can interact with rosuvastatin (Crestor) and citalopram (Celexa).

Rydapt is used in certain adults to treat:

Rydapt’s active ingredient is midostaurin. (An active ingredient is what makes a drug work.)

An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.

Keep reading to learn about Rydapt’s possible interactions. And for more information about Rydapt, including details about its uses, see this article.

Before you start taking Rydapt, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Rydapt interacts with herbs or vitamins and supplements, see the “Are there other interactions with Rydapt?” section below.)

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

The table below lists drugs that may interact with Rydapt. Keep in mind that this table does not include all drugs that may interact with Rydapt. For more information about some of these interactions, see the “Drug interactions explained” section below.

Drug group or drug nameDrug examplesWhat can happen
certain other cancer drugs• idelalisib (Zydelig)
• mitotane (Lysodren)
can increase the risk of side effects from Rydapt or make Rydapt less effective
certain statin drugs• atorvastatin (Atorvaliq, Lipitor)
• pitavastatin (Livalo, Zypitamag)
• pravastatin
• rosuvastatin (Crestor)
• simvastatin (FloLipid, Zocor)
can increase the risk of side effects from the statin drug
certain antifungal drugs fluconazole (Diflucan)
• itraconazole (Sporanox, Tolsura)
• ketoconazole
• voriconazole (Vfend)
can increase the risk of side effects from either drug
certain seizure drugs• carbamazepine (Carbatrol, Tegretol, others)
• phenytoin (Dilantin, Phenytek)
• phenobarbital (Sezaby)
can make Rydapt less effective
certain antibiotic drugs• azithromycin (Zithromax)
• clarithromycin
• erythromycin (Eryc, Ery-Tab, others)
can increase the risk of side effects from either drug
certain irregular heart rhythm drugsamiodarone (Nexterone, Pacerone)
• flecainide
quinidine
• sotalol (Betapace, Sotylize, others)
can increase the risk of long QT syndrome
certain antidepressant drugs• citalopram (Celexa)
• fluoxetine (Prozac)
• nefazodone
• sertraline (Zoloft)
can increase the risk of side effects from either drug
enzalutamide (Xtandi)can make Rydapt less effective
bupropion (Aplenzin, Wellbutrin XL, others)can make bupropion less effective
diltiazem (Cardizem, Cartia XT, others)can increase the risk of side effects from Rydapt

Certain health conditions or other factors could raise your risk of harm if you take Rydapt. In such cases, your doctor may not prescribe Rydapt for you. These are known as contraindications. The list below includes contraindications of Rydapt.

If you’ve had an allergic reaction: If you’ve had an allergic reaction to Rydapt or any of its ingredients, your doctor likely won’t prescribe Rydapt for you. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.

Before you start taking Rydapt, talk with your doctor if any of the factors above apply to you. Your doctor can determine whether Rydapt is safe for you to take.

Rydapt is not known to interact with alcohol. But Rydapt and alcohol can cause some similar side effects, such as headache, diarrhea, and nausea. So these side effects may worsen if you drink alcohol during your Rydapt treatment.

If you have questions about consuming alcohol while taking Rydapt, talk with your doctor or pharmacist.

Learn more about certain drug interactions that can occur with Rydapt.

Interaction with statin drugs

Rydapt can interact with certain statin drugs, which are used to treat high cholesterol.

Examples of statin drugs that may interact with Rydapt include:

  • atorvastatin (Atorvaliq, Lipitor)
  • pitavastatin (Livalo, Zypitamag)
  • pravastatin
  • rosuvastatin (Crestor)
  • simvastatin (FloLipid, Zocor)

What could happen

Taking Rydapt with certain statins can raise your risk of muscle problems and other side effects from the statin. This is because Rydapt can slow down the activity of proteins that help move the statin through your body. This could lead to a higher level of the statin in your system, raising your risk of side effects from the drug.

What you can do

Before taking Rydapt, tell your doctor if you’re taking a statin. They can tell you whether Rydapt may interact with it and whether it’s safe to take these drugs together. In some cases, your doctor may switch you to a different statin that isn’t known to interact with Rydapt.

If you have questions about taking Rydapt with statins, talk with your doctor or pharmacist.

Interaction with certain antidepressant drugs

Rydapt can interact with certain antidepressant drugs, which are used to treat mental health conditions.

Examples of antidepressants that may interact with Rydapt include:

  • citalopram (Celexa)
  • fluoxetine (Prozac)
  • nefazodone
  • sertraline (Zoloft)

What could happen

Taking Rydapt with certain antidepressants can raise your risk of side effects from either drug.

This is because certain antidepressants may slow the activity of an enzyme (protein) that breaks down Rydapt in your body. This could lead to a high level of Rydapt in your system, raising the risk of side effects.

In addition, Rydapt and certain antidepressants can both cause long QT syndrome as a side effect. (Long QT syndrome is a type of irregular heart rhythm.) So taking these drugs together can raise your risk of this side effect.

What you can do

Before starting Rydapt treatment, tell your doctor if you take an antidepressant. They can tell you whether it’s safe to take the medications together. If needed, your doctor may switch you to an antidepressant that isn’t known to interact with Rydapt.

If you have questions about taking Rydapt with an antidepressant, talk with your doctor or pharmacist.

Interaction with bupropion

Rydapt can interact with bupropion (Aplenzin, Wellbutrin XL, others). This drug is used to treat certain mental health conditions, including depression.

What could happen

Taking Rydapt with bupropion could make bupropion less effective. This is because Rydapt may speed up the activity of an enzyme that breaks down bupropion in your body. Taking these drugs together could lead to a low level of bupropion in your system and make the drug less effective.

What you can do

If you take Rydapt with bupropion, your doctor may need to increase your dosage of bupropion. You should not take a higher dose of either medication than your doctor prescribes.

If you have questions about taking Rydapt with bupropion, talk with your doctor or pharmacist.

Rydapt may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Rydapt.

Does Rydapt interact with supplements?

Before you start taking Rydapt, talk with your doctor and pharmacist about any herbs or vitamins and supplements you take. Sharing this information with them may help you avoid possible interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Rydapt interactions with herbs

Rydapt can interact with St. John’s wort. This is an herbal supplement that may be used to ease symptoms of depression and other conditions.

St. John’s wort may speed up the activity of an enzyme (protein) that helps break down Rydapt in your body. This can lower the level of Rydapt in your body and make the drug less effective.

For this reason, your doctor will likely recommend alternatives to St. John’s wort for your condition.

Rydapt and vitamins

There are currently no reports of Rydapt interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Rydapt.

Does Rydapt interact with food?

Rydapt may interact with grapefruit products. Taking the drug with grapefruit or grapefruit juice could cause your body to break down Rydapt more slowly than usual. This can raise the level of Rydapt in your system and increase your risk of side effects from the drug.

If you have questions about eating specific foods during your Rydapt treatment, talk with your doctor.

Does Rydapt interact with vaccines?

It may not be safe to receive vaccines for cholera (Vaxchora) or COVID-19 (Comirnaty, Spikevax) during your Rydapt treatment.

These vaccines work by helping your immune system recognize the conditions the vaccines protect against. But Rydapt may lower the activity of your immune system. Getting these vaccines while you’re taking Rydapt could make the vaccines less effective.

If you have questions about getting specific vaccines during your Rydapt treatment, talk with your doctor.

Does Rydapt interact with lab tests?

There are currently no reports of Rydapt interacting with lab tests. If you have questions about having certain lab tests during your treatment with Rydapt, talk with the healthcare professional ordering the test.

Does Rydapt interact with cannabis or CBD?

There are currently no reports of Rydapt interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Rydapt.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions or other health factors may raise the risk of interactions with Rydapt. Before taking Rydapt, talk with your doctor about your health history. They’ll determine whether Rydapt is right for you.

Health conditions or other factors that might interact with Rydapt include:

Pregnancy: Rydapt may not be safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before taking Rydapt.

If you do take Rydapt while pregnant, consider enrolling in the drug’s pregnancy registry. This registry collects details about pregnancy issues reported with Rydapt. To learn more, call 888-669-6682 or talk with your doctor.

Breastfeeding: It’s unknown whether Rydapt is safe to take while breastfeeding or whether it passes into breast milk. But because of the risk of serious side effects, breastfeeding is not recommended during your Rydapt treatment. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.

Allergic reaction: If you’ve had an allergic reaction to Rydapt or any of its ingredients, your doctor will likely not prescribe Rydapt. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.

Taking certain steps can help you avoid interactions with Rydapt. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:

  • whether you drink alcohol or use cannabis
  • other medications you take, as well as any vitamins, supplements, and herbs (they can also help you fill out a medication list)
  • what to do if you start taking a new drug during your Rydapt treatment

It’s also important to understand Rydapt’s label and other paperwork that may come with the drug. Colored stickers that describe interactions may be on the label. And the paperwork (sometimes called the patient package insert or medication guide) may have other details about interactions. (If you did not get paperwork with Rydapt, ask your pharmacist to print a copy for you.)

If you have difficulty reading or understanding this information, your doctor or pharmacist can help.

Taking Rydapt exactly as prescribed can also help prevent interactions.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.