Rybelsus (semaglutide) is a prescription drug that’s used to manage blood sugar levels in adults with type 2 diabetes. Rybelsus comes as a tablet that you’ll swallow with a little water each day.

Rybelsus is used in adults with type 2 diabetes to manage high blood sugar levels. It belongs to a group of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. Note that Rybelsus is not meant for use to treat type 1 diabetes.

The active ingredient in Rybelsus is semaglutide. An active ingredient is what makes a drug work.

This article describes the dosages of Rybelsus, as well as its strengths and how to take it. To learn more about Rybelsus, see this in-depth article.

Rybelsus Images


Rybelsus is a tablet that you’ll swallow before your first food or beverage of each day. For many people, this will be each morning before breakfast. The drug comes in several strengths.

Note: This table highlights the basics of Rybelsus’s dosage. Doses are listed in milligrams (mg).

Starting dosage (first 30 days)Lowest effective dosageMaximum dosage
3 mg once daily7 mg once daily14 mg once daily

What is Rybelsus’s form?

Rybelsus comes as a tablet that you swallow.

What strengths does Rybelsus come in?

Rybelsus is available in three strengths:

  • 3 mg
  • 7 mg
  • 14 mg

What are the usual dosages of Rybelsus?

The information below describes dosages that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosage for type 2 diabetes

When you’re first prescribed Rybelsus, you’ll take a starting dose of 3 mg. You’ll take this every day for the first 30 days. This lower dose allows your body to get used to the drug.

After 30 days, your doctor will increase your dosage to 7 mg taken once per day.

While taking Rybelsus, you’ll carefully monitor your blood sugar level. Depending on how your blood sugar level responds to the medication, your doctor may keep your dosage at 7 mg per day or increase it to 14 mg per day. Dosage increases are only made after you’ve taken your current dosage for at least 30 days. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The maximum dosage of Rybelsus is 14 mg per day.

Is Rybelsus used long term?

Yes, Rybelsus is usually used as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.

Below are answers to some commonly asked questions about Rybelsus’s dosage.

Is there a 3-mg daily dose of Rybelsus?

Yes, the 3-mg daily dose of Rybelsus is used as a starting dose. You’ll take the 3-mg dose each day for the first 30 days of your treatment. Starting doses give your body time to get used to a drug and can lower the risk of side effects. But the 3-mg dose is not enough to manage your blood sugar level. After taking 3 mg each day for 30 days, your doctor will increase your dose.

Can Rybelsus be used for weight loss? If so, what’s the dosage?

Rybelsus is not approved by the Food and Drug Administration (FDA) for weight loss. Although it’s a glucagon-like peptide-1 (GLP-1) agonist, it’s used specifically to manage blood sugar levels in adults with type 2 diabetes.

Because Rybelsus isn’t recommended for weight loss, the drug’s manufacturer doesn’t provide recommended dosages for this use.

Wegovy (semaglutide) is a GLP-1 agonist that’s specifically made for weight loss. If you want to learn more about Wegovy for weight loss, talk with your doctor.

What is Rybelsus 14 mg used for?

Your doctor may prescribe the 14-mg strength of Rybelsus if the 7-mg dose is not managing your blood sugar well.

When you start Rybelsus, you’ll take the 3-mg strength for 30 days. Then you’ll take the 7-mg dose. Depending on how your blood sugar level responds to the medication, your doctor may increase your dosage to 14 mg per day. They will wait to increase your dosage until you’ve taken the 7-mg dose for at least 30 days.

The maximum dosage of Rybelsus is 14 mg per day.

Your dosage of diabetes medications, including Rybelsus, may need to change if you experience:

If any of these apply to you, talk with your doctor. They may ask you to check your blood sugar level more often and may decide to adjust your Rybelsus dosage.

Rybelsus is a tablet that’s taken once per day. It should be taken alone, without other medications, on an empty stomach (before consuming any food or drinks for the first time in a day). Most people will take Rybelsus in the morning. But for some, the best time to take the drug will depend on their schedule.

Before you eat, it’s important to wait at least 30 minutes after taking Rybelsus. If you wait less than 30 minutes, your body may not absorb enough of the drug. This can make Rybelsus less effective. However, if you wait more than 30 minutes, this can increase the amount of Rybelsus your body absorbs. As a result, your risk of side effects, including low blood sugar, increases.

You should also wait 30 minutes after taking Rybelsus before taking other medications that you swallow. This helps avoid possible drug interactions. To learn about Rybelsus’s interactions, see this article.

Rybelsus should not be chewed, crushed, or split. Take Rybelsus with no more than 4 ounces (1/2 cup) of water. If you have trouble swallowing tablets, talk with your doctor about ways to make taking Rybelsus easier.

For information on the expiration, storage, and disposal of Rybelsus, see this article.

Accessible drug containers and labels

Some pharmacies provide medication labels that:

  • have large print or use braille
  • feature a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

If you have trouble opening medication bottles, let your pharmacist know. They may be able to supply Rybelsus in an easy-open container. They may also have tips to help make it simpler to open the drug’s container.

If you miss a dose of Rybelsus, you should skip the dose. Then, take your next dose the following day at the usual time. You should not take two doses at once to make up for a missed dose.

If you need help remembering to take your dose of Rybelsus on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Do not take more Rybelsus than your doctor prescribes as this can cause harmful effects.

What to do in case you take too much Rybelsus

Call your doctor right away if you think you’ve taken too much Rybelsus. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

The sections above describe the usual dosages provided by the drug’s manufacturer. If your doctor recommends Rybelsus for you, they’ll prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Rybelsus without your doctor’s recommendation. Only take Rybelsus exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • How will I know if my current dosage of Rybelsus is working?
  • If I exercise more, will my dosage of Rybelsus be decreased?
  • Should I expect an increase in side effects with higher doses of Rybelsus?

To learn more about Rybelsus, see these articles:

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.