Rezurock (bulmosudil mesylate) is a prescription drug that’s used to treat chronic graft-versus-host disease (chronic GVHD). The drug comes as an oral tablet. It’s usually taken once per day.

Rezurock is prescribed to treat chronic (slow-onset) GVHD in adults and some children. It’s usually prescribed after two or more other GVHD treatments haven’t worked.

The active ingredient in Rezurock is belumosodil mesylate. (An active ingredient is what makes a drug work.).

Rezurock belongs to a group of drugs called kinase inhibitors. This article describes the dosage of Rezurock, as well as its strength and how to take it. To learn more about Rezurock, see this in-depth article.

This section describes the usual dosage of Rezurock. Keep reading to learn more.

What is Rezurock’s form?

Rezurock is available as an oral tablet.

What strength does Rezurock come in?

Rezurock comes in a strength of 200 milligrams (mg).

What is the usual dosage of Rezurock?

The information below describes the dosage that’s commonly recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosage for chronic graft-versus-host disease

The usual dosage of Rezurock for adults with chronic graft-versus-host disease is 200 mg once per day.

What’s the dosage of Rezurock for children?

Rezurock may be prescribed for children ages 12 years and older. Like adults, children will take 200 mg of Rezurock once per day for treatment of chronic graft-versus-host disease.

For more information about Rezurock’s dosage for children, talk with your child’s doctor.

Is Rezurock used long term?

Yes, Rezurock is usually used as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.

Dosage adjustments

If you take certain medications, your doctor may increase your Rezurock dosage.

For example, proton pump inhibitors (PPIs) are medications used to decrease stomach acid and relieve acid reflux symptoms. If you’re taking a PPI, it can affect how much Rezurock your body absorbs. Examples of PPIs include:

If you take one of these medications, your doctor may increase your dosage of Rezurock.

Some drugs can increase the activity of a liver enzyme (protein) that breaks down Rezurock. Taking one of these medications with Rezurock can cause the levels of Rezurock to be lower than usual in your body. This can decrease the effectiveness of Rezurock. Examples of drugs that may increase the activity of this enzyme and decrease Rezurock levels include:

If you take one of these medications, your doctor may increase your dosage of Rezurock.

Talk with your doctor about all the medications you take, including over-the-counter medications. This way your doctor will know whether your Rezurock dosage needs to be adjusted.

Rezurock comes as a tablet that you’ll swallow whole. Do not crush, chew, or cut the tablet. If you have trouble swallowing tablets, see this article for tips on how to take this form of medication.

You should take Rezurock once per day with food. Try to take it at about the same time each day. This helps keep a steady level of the drug in your body.

Accessible drug containers and labels

Some pharmacies provide medication labels that:

  • have large print
  • use braille
  • feature a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

Let your pharmacist know if you have trouble opening medication bottles. They may have tips to help, or they may be able to supply Rezurock in an easy-open container.

If you miss a dose of Rezurock, take it as soon as you remember. But if it’s almost time for your next dose, skip the missed dose and take your next dose at its usual time. If you’re not sure whether you should take a missed dose, talk with your doctor or pharmacist. Don’t take extra doses to make up for a missed dose.

If you need help remembering to take your dose of Rezurock on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Do not take more Rezurock than your doctor prescribes, as this can lead to harmful effects.

What to do in case you take too much Rezurock

Call your doctor right away if you think you’ve taken too much Rezurock. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Below are answers to some commonly asked questions about Rezurock’s dosage.

Do Rezurock and Jafaki have similar dosages?

Rezurock and Jafaki (ruxolitinib) both come as tablets, but their dosages are different.

Rezurock is available in a single strength, whereas Jafaki is available in five different strengths.

Rezurock is usually taken once per day and Jafaki is taken twice per day.

To learn more about Jafaki’s dosages, see this article. To learn more about how these drugs compare, talk with your doctor.

How long does it take for Rezurock to start working?

Rezurock starts to work after your first dose, but it’ll take some time for you to notice its effects. In studies, doctors could see Rezurock’s effects on physical examination and laboratory tests after 1–2 months.

If you have questions about what to expect from your Rezurock treatment, talk with your doctor.

The sections above describe the usual dosage provided by the manufacturer. If your doctor recommends Rezurock for you, they’ll prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Rezurock without your doctor’s recommendation. Only take Rezurock exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

To learn more about Rezurock, see these articles:

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.