Reyvow (lasmiditan) is a prescription oral tablet used to treat migraine episodes in adults. This drug can interact with alcohol, other medications, and some supplements. For example, Reyvow can interact with beta-blockers and dextromethorphan (Delsym).

An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.

Before you start taking Reyvow, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Reyvow interacts with herbs or vitamins and supplements, see the “Are there other interactions with Reyvow?” section below.)

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

The table below lists drugs that may interact with Reyvow. Keep in mind that this table does not include all drugs that may interact with Reyvow. For more information about some of these interactions, see the “Drug interactions explained” section below.

Drug group or drug nameDrug examplesWhat can happen
beta-blockersmetoprolol (Lopressor, Toprol XL, others)
nadolol (Corgard)
propranolol (Hemangeol, Innopran XL, others)
can increase the risk of slow heart rate from Reyvow and beta-blockers
calcium channel blockers (CCBs)amlodipine (Katerzia, Norvasc, others)
diltiazem (Cardizem, Tiazac, others)
verapamil (Verelan, Verelan PM)
can increase the risk of slow heart rate from Reyvow and CCBs
opioidsfentanyl (Actiq, Sublimaze, others)
hydrocodone (Hysingla ER)
oxycodone (Oxycontin, Roxicodone, others)
can increase the risk of side effects from Reyvow and opioids
selective serotonin reuptake inhibitors (SSRIs)citalopram (Celexa)
fluoxetine (Prozac)
sertraline (Zoloft)
can increase the risk of serotonin syndrome from Reyvow and SSRIs
serotonin-norepinephrine reuptake inhibitors (SNRIs)desvenlafaxine (Pristiq)
duloxetine (Cymbalta)
venlafaxine (Effexor XR)
can increase the risk of serotonin syndrome from Reyvow and SNRIs
statinsatorvastatin (Atorvaliq, Lipitor)
lovastatin (Altoprev)
simvastatin (FloLipid, Zocor)
can increase the risk of side effects from statins
certain antihistamines• diphenhydramine (Benadryl)
hydroxyzine (Vistaril)
meclizine (Antivert)
can increase the risk of sleepiness from Reyvow and certain antihistamines
digoxin (Lanoxin)can increase the risk of side effects from digoxin
trazodonecan increase the risk of sleepiness from Reyvow and trazodone
dextromethorphan (Delsym)can increase the risk of serotonin syndrome from Reyvow and dextromethorphan

Drinking alcohol during Reyvow treatment is not recommended. This is because Reyvow and alcohol can cause some similar side effects, such as dizziness and sleepiness. These side effects may be worsened if you drink alcohol during your Reyvow treatment.

If you have questions about avoiding alcohol while taking Reyvow, talk with your doctor or pharmacist.

Learn more about certain drug interactions that can occur with Reyvow.

Interaction with beta-blockers

Reyvow can interact with beta-blockers, which are prescribed to treat high blood pressure and other heart-related conditions.

Examples of beta-blockers include:

What could happen

Reyvow and beta-blockers can both cause slow heart rate, so taking these drugs together can raise your risk of this side effect.

What you can do

If your doctor has you take Reyvow with a beta-blocker, they may closely monitor your heart rate during your treatment.

Tell your doctor right away if you have fatigue (low energy), lightheadedness, or shortness of breath. These could be symptoms of a slow heart rate. Your doctor can determine whether it’s safe to keep taking Reyvow with the beta-blocker.

If you have questions about this interaction, talk with your doctor or pharmacist.

Interaction with SSRIs

Reyvow can interact with SSRIs. These medications are prescribed to treat depression and other mental health conditions.

Examples of SSRI medications include:

What could happen

Both Reyvow and SSRIs can cause serotonin syndrome, so taking these drugs together can raise your risk of this side effect.

With serotonin syndrome, you have a high level of the chemical serotonin in your body. In extreme cases, this condition can be life threatening. Symptoms of serotonin syndrome can include fast heart rate, confusion, and excessive sweating.

What you can do

If you take Reyvow with SSRIs, watch for the symptoms of serotonin syndrome listed above. If you have these symptoms, contact your doctor right away. But if your symptoms seem severe or life threatening, call 911 or your local emergency number.

If you have serotonin syndrome, your doctor will likely recommend that you stop taking these medications together. They can recommend other treatment options instead.

If you have questions about taking Reyvow with SSRIs, talk with your doctor or pharmacist.

Interaction with dextromethorphan

Reyvow can interact with dextromethorphan (Delsym), which is prescribed to treat a cough.

What could happen

Both Reyvow and dextromethorphan can cause serotonin syndrome. Taking these medications together could raise your risk of this side effect.

Serotonin syndrome is caused by a high level of the chemical serotonin in your system. In severe cases, this condition can be life threatening. Symptoms of serotonin syndrome can include fast heart rate, confusion, and excessive sweating.

What you can do

If you take Reyvow with dextromethorphan, it’s important to watch for the symptoms of serotonin syndrome listed above. If you have symptoms of this condition, talk with your doctor right away. But if your symptoms seem life threatening or severe, call 911 or your local emergency number.

If you have serotonin syndrome, your doctor will likely have you stop taking these medications together. They can recommend alternatives to either Reyvow or dextromethorphan.

If you have questions about taking Reyvow with dextromethorphan, talk with your doctor or pharmacist.

Reyvow may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Reyvow.

Does Reyvow interact with supplements?

Before you start taking Reyvow, talk with your doctor and pharmacist about any herbs or vitamins and supplements you take. Sharing this information with them may help you avoid possible interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Reyvow interactions with herbs

Reyvow can interact with St. John’s wort, which is taken to ease symptoms of depression and other conditions. Both Reyvow and St. John’s wort can cause serotonin syndrome, so taking the two together can raise your risk of this side effect.

With serotonin syndrome, you have a high level of the chemical serotonin in your body. In severe cases, serotonin syndrome can be life threatening. Symptoms of this condition can include fast heart rate, confusion, and excessive sweating.

If you take Reyvow with St. John’s wort, watch for symptoms of serotonin syndrome. If you have any symptoms, contact your doctor right away. But if your symptoms seem severe or life threatening, call 911 or your local emergency number.

If you have questions about taking Reyvow with St. John’s wort, talk with your doctor or pharmacist.

Reyvow and vitamins

There are currently no reports of Reyvow interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Reyvow.

Does Reyvow interact with food?

There are currently no reports of Reyvow interacting with food. If you have questions about eating certain foods during your treatment with Reyvow, talk with your doctor.

Does Reyvow interact with vaccines or lab tests?

There are currently no reports of Reyvow interacting with vaccines or lab tests. If you have questions about getting certain vaccines or having lab tests done during your Reyvow treatment, talk with your doctor.

Does Reyvow interact with cannabis or CBD?

Cannabis(commonly called marijuana) and cannabis products, such as cannabidiol (CBD), have been specifically reported to interact with Reyvow.

Taking Reyvow with cannabis products could increase your risk of side effects from either substance. Examples include dizziness and sleepiness.

Before you start treatment with Reyvow, tell your doctor and pharmacist if you use cannabis. By sharing this information with them, you may help prevent possible interactions.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions or other health factors may raise the risk of interactions with Reyvow. Before taking Reyvow, talk with your doctor about your health history. They’ll determine whether Reyvow is right for you.

Health conditions or other factors that might interact with Reyvow include:

High blood pressure: Before taking Reyvow, tell your doctor if you have high blood pressure. Reyvow may temporarily raise your blood pressure, which could worsen your condition. Your doctor can determine whether Reyvow is a safe treatment option for you.

Liver problems: If you have a liver problem, talk with your doctor before starting Reyvow treatment. It’s not known whether Reyvow is safe for people with severe liver problems. Your doctor may prescribe a treatment other than Reyvow.

Slow heart rate: Before taking Reyvow, tell your doctor if you have a slow heart rate. Reyvow may also cause a slow heart rate, which could worsen your condition. Your doctor can tell you whether Reyvow is a safe treatment option for you.

Pregnancy: It’s not known whether Reyvow is safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before taking Reyvow.

If you do take Reyvow while pregnant, consider enrolling in the drug’s pregnancy registry. This registry collects details about pregnancy issues reported with Reyvow. To learn more, call 833-464-4724 or talk with your doctor.

Breastfeeding: It’s not known whether it’s safe to take Reyvow while breastfeeding. The drug passes into breast milk, but it isn’t known whether the drug may cause side effects in a child who’s breastfed. If you’re breastfeeding or planning to do so, talk with your doctor about your options.

Allergic reaction: If you’ve had an allergic reaction to Reyvow or any of its ingredients, your doctor will likely not prescribe Reyvow. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.

Taking certain steps can help you avoid interactions with Reyvow. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include the following:

  • Whether you drink alcohol or use cannabis.
  • Other medications you take, as well as any vitamins, supplements, and herbs. Your doctor or pharmacist can help you fill out a medication list.
  • What to do if you start taking a new drug during your Reyvow treatment.

It’s also important to understand Reyvow’s label and other paperwork that may come with the drug. Colored stickers that describe interactions may be on the label. And the paperwork (sometimes called the patient package insert or medication guide) may have other details about interactions. (If you did not get paperwork with Reyvow, ask your pharmacist to print a copy for you.)

If you have difficulty reading or understanding this information, your doctor or pharmacist can help.

Taking Reyvow exactly as prescribed can also help prevent interactions.

If you still have questions about Reyvow and its possible interactions, talk with your doctor.

Questions you may want to ask your doctor include:

  • Do any of my health conditions interact with Reyvow?
  • Do I need to tell you if I start taking another medication or supplement during my Reyvow treatment?
  • Do other drugs that treat migraine episodes have similar interactions to Reyvow?

To learn more about Reyvow, see these articles:

To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters. You may also want to check out the online communities at Bezzy. It’s a place where people with certain conditions can find support and connect with others.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.