Repatha (evolocumab) is a prescription drug that’s used to treat some types of high cholesterol. It’s also used to lower certain heart-related risks. This drug isn’t known to interact with alcohol, other medications, or supplements.
Repatha is used to:
- treat high cholesterol in adults and some children with certain conditions
- lower the risk of stroke, heart attack, or the need for certain heart procedures in adults with heart disease
Repatha comes as a liquid solution that’s injected under your skin.
An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.
Keep reading to learn about Repatha’s possible interactions. And for more information about Repatha, including details about its uses, see this article.
Certain health conditions or other factors could raise your risk of harm if you take Repatha. In such cases, your doctor may not prescribe Repatha for you. These are known as contraindications. Repatha has one contraindication, described below.
If you’ve had an allergic reaction. If you’ve had an allergic reaction to Repatha or any of its ingredients, your doctor likely won’t prescribe Repatha. This is because using the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.
Repatha is not known to interact with alcohol. But Repatha and alcohol may cause some of the same side effects, including dizziness and headache. Drinking alcohol during your Repatha treatment could worsen these side effects. (For more information about Repatha’s side effects, see this article.)
If you drink alcohol, talk with your doctor about how much may be safe to consume during your Repatha treatment.
Repatha isn’t known to interact with other drugs. But new interactions may be recognized in the future. For example, possible interactions could be reported by people who’ve used Repatha since it became available.
Before you start using Repatha, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Repatha interacts with supplements, herbs, and vitamins, see the “Are there other interactions with Repatha?” section below.)
If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.
Repatha is not known to interact with supplements, foods, vaccines, or lab tests. See below for details.
Does Repatha interact with supplements?
Before you start using Repatha, talk with your doctor and pharmacist about any supplements, herbs, and vitamins you take. Sharing this information with them may help you avoid possible interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Does Repatha interact with food?
There are currently no reports of Repatha interacting with food. If you have questions about eating certain foods during your treatment with Repatha, talk with your doctor.
Does Repatha interact with vaccines or lab tests?
There are currently no reports of Repatha interacting with vaccines or lab tests. If you have questions about getting specific vaccines or having lab tests done during your Repatha treatment, talk with your doctor.
Does Repatha interact with cannabis or CBD?
There are currently no reports of Repatha interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Repatha.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Certain medical conditions or other health factors may raise the risk of interactions with Repatha. Before using Repatha, talk with your doctor about your health history. They’ll determine whether Repatha is right for you.
Health conditions or other factors that might interact with Repatha include:
Pregnancy. It’s not known whether Repatha is safe to receive during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor. They can tell you about the risks and benefits of using Repatha while pregnant.
Breastfeeding. It’s not known if it’s safe to receive Repatha while breastfeeding. It isn’t known whether the drug passes into breast milk or could cause side effects in a child who’s breastfed. If you’re breastfeeding or planning to breastfeed, talk with your doctor before starting Repatha treatment.
Allergic to latex or rubber. If you’re allergic to latex or rubber, your doctor will likely not prescribe certain forms of Repatha for you. This is because the prefilled syringe and autoinjector forms of Repatha contain a type of rubber that’s made from latex.
Instead, your doctor may prescribe the cartridge form of Repatha, which doesn’t contain rubber and may be safe for people with allergies to latex or rubber. To learn more about Repatha’s forms, see this article.
Allergic reaction. If you’ve had an allergic reaction to Repatha or any of its ingredients, your doctor will likely not prescribe Repatha. This is because using the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.
Find answers to some frequently asked questions about Repatha and possible interactions.
Is it safe to take Repatha with other cholesterol medications?
Yes, it should be safe. Repatha isn’t known to interact with any cholesterol medications.
Repatha can be used to treat high cholesterol in people with certain conditions. Depending on your condition, your doctor may prescribe Repatha with other cholesterol medications. An example is statin drugs, such as atorvastatin (Lipitor) and simvastatin (FloLipid, Zocor).
Your doctor will determine whether you should take Repatha with other cholesterol medications.
Can I take Repatha if I have diabetes?
Possibly, if your doctor recommends it.
But it’s important to note that Repatha may cause high blood sugar,* which could worsen diabetes. If you have diabetes, your doctor may have you check your blood sugar levels more often than usual during your Repatha treatment.
To learn more about Repatha and diabetes, talk with your doctor.
* To learn more about Repatha’s side effects, see this article.
Taking certain steps can help you avoid interactions with Repatha. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:
- Whether you drink alcohol or use cannabis.
- Other medications you take, as well as any vitamins, supplements, and herbs. Your doctor or pharmacist can help you fill out a
- What to do if you start taking a new drug during your Repatha treatment.
It’s also important to understand Repatha’s
If you have trouble reading or understanding this information, your doctor or pharmacist can help.
Using Repatha exactly as prescribed can also help prevent interactions.
If you still have questions about Repatha and its possible interactions, talk with your doctor.
Questions you may want to ask your doctor include:
- How do Repatha’s interactions compare with similar drugs used for my condition?
- What should I do if I suspect a possible drug interaction with Repatha?
- Should I tell you if I start any new supplements or medications during my Repatha treatment?
To learn more about Repatha, see these articles:
- All About Repatha
- Side Effects of Repatha: What You Need to Know
- Dosage Details for Repatha
- Repatha and Cost: What You Need to Know
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.