Praluent (alirocumab) is a prescription drug that’s used to reduce certain risks related to the heart. It’s also used to decrease LDL cholesterol. This drug isn’t known to interact with alcohol, other medications, or supplements.

Praluent is used to:

Praluent comes as a liquid solution that’s injected under your skin.

An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.

Keep reading to learn about Praluent’s possible interactions. And for more information about Praluent, including details about its uses, see this article.

Praluent isn’t known to interact with other drugs. But interactions with other medications could be recognized in the future. For example, new interactions could be reported by people who’ve injected Praluent since it became available.

Before you start treatment with Praluent, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (You can learn whether Praluent interacts with herbs or vitamins or supplements. See the “Are there other interactions with Praluent?” section below.)

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

Certain health conditions or other factors could raise your risk of harm if you inject Praluent. In such cases, your doctor may not prescribe Praluent for you. These are known as contraindications. Praluent has one contraindication.

If you’ve had an allergic reaction: If you’ve had an allergic reaction to Praluent or any of its ingredients, your doctor likely won’t prescribe Praluent for you. This is because injecting the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.

Before you start treatment with Praluent, talk with your doctor if the factor above applies to you. Your doctor can determine whether Praluent is safe for you.

Praluent is not known to interact with alcohol. But Praluent and a large amount of alcohol can cause liver problems. During Praluent treatment, this side effect is more likely if you consume a lot of alcohol.

If you have questions about consuming alcohol during Praluent treatment, talk with your doctor or pharmacist.

Praluent may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other interactions possible with Praluent.

Does Praluent interact with supplements?

Before you start treatment with Praluent, talk with your doctor and pharmacist about any herbs or vitamins or supplements you take. Sharing this information with them may help you avoid possible interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Praluent and herbs

Praluent currently has no reports of interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products during Praluent treatment.

Praluent and vitamins

Praluent currently has no reports of interacting with vitamins. But this doesn’t mean that interactions with vitamins won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products during Praluent treatment.

Does Praluent interact with food?

Praluent currently has no reports of interacting with food. If you have questions about eating certain foods during treatment with Praluent, talk with your doctor.

Does Praluent interact with vaccines?

Praluent currently has no reports of interacting with vaccines. If you have questions about getting certain vaccines during treatment with Praluent, talk with your doctor.

Does Praluent interact with lab tests?

Praluent currently has no reports of interacting with lab tests. If you have questions about having certain lab tests during treatment with Praluent, talk with the healthcare professional ordering the test.

Does Praluent interact with cannabis or CBD?

Praluent currently has no reports of interactions with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Praluent.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions or other health factors may raise the risk of interactions with Praluent. Before starting Praluent, talk with your doctor about your health history. They’ll determine whether Praluent is right for you.

Health conditions or other factors that might interact with Praluent include:

Pregnancy: It’s not known whether Praluent is safe to inject during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before injecting Praluent.

If you do have treatment with Praluent while pregnant, consider enrolling in the drug’s pregnancy registry. This registry collects details about pregnancy issues reported with Praluent. To learn more, call 844-734-6643 or talk with your doctor.

Breastfeeding: It’s not known whether it’s safe to inject Praluent while breastfeeding. It isn’t known whether the drug passes into breast milk or whether the drug may cause side effects in a child who’s breastfed. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.

Allergic reaction: If you’ve had an allergic reaction to Praluent or any of its ingredients, your doctor likely won’t prescribe Praluent. This is because injecting the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.

Taking certain steps can help you avoid interactions with Praluent. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:

  • Whether you drink alcohol or use cannabis.
  • Other medications you take, as well as any vitamins, supplements, and herbs. Your doctor or pharmacist can help you fill out a medication list.
  • What to do if you start taking a new drug during your Praluent treatment.

It’s also important to understand Praluent’s label and other paperwork that may come with the drug. Colored stickers that describe interactions may be on the label. And the paperwork (sometimes called the patient package insert or medication guide) may have other details about interactions. (If you did not get paperwork with Praluent, ask your pharmacist to print a copy for you.)

If you have difficulty reading or understanding this information, your doctor or pharmacist can help.

Injecting Praluent exactly as prescribed can also help prevent interactions.

If you still have questions about Praluent and its possible interactions, talk with your doctor.

Questions you may want to ask your doctor include:

  • What should I do if I suspect a possible drug interaction with Praluent?
  • Should I tell you if I start any new medications or supplements during treatment with Praluent?
  • How do Praluent’s interactions compare with those of similar drugs, such as Repatha?

To learn more about Praluent, see these articles:

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.