Nuvigil (armodafinil) is a prescription drug that helps improve wakefulness in adults with certain conditions. This drug can interact with other medications and some supplements. For example, Nuvigil can interact with certain birth control treatments.

Nuvigil is used to help improve wakefulness in adults who have excessive sleepiness caused by certain conditions. These include any of the following:

Nuvigil comes as oral tablets. Its active ingredient is armodafinil.

An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.

Keep reading to learn about Nuvigil’s possible interactions. And for more information about Nuvigil, including details about its uses, see this article.

Before you start taking Nuvigil, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Nuvigil interacts with herbs or vitamins and supplements, see the “Are there other interactions with Nuvigil?” section below.)

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

The table below lists some drugs that may interact with Nuvigil but not all. For more information about some of these interactions, see the “Drug interactions explained” section below.

Drug group or drug nameDrug examplesWhat can happen
certain hormonal birth control medications• ethinyl estradiol/norelgestromin (Onsura, Xulane)
• ethinyl estradiol/norethindrone (Aranelle, others)
• others
can make certain hormonal birth control medications less effective
non-selective monoamine oxidase inhibitors (MAOIs)• isocarboxazid (Marplan)
• phenelzine (Nardil)
can increase the risk of side effects from the MAOI
certain benzodiazepines• midazolam
• triazolam (Halcion)
can make the benzodiazepine less effective
cobicistat (Tybost) and medications that contain itStribild (elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate)
• Evotaz (atazanavir/cobicistat)
• others
• can make the medication containing cobicistat less effective
• can increase the risk of side effects from Nuvigil
cyclosporine (Gengraf, Neoral, Sandimmune)can make cyclosporine less effective
diazepam (Valium)can increase the risk of side effects from diazepam
omeprazole (Prilosec)can increase the risk of side effects from omeprazole
phenytoin (Dilantin)• can increase the risk of side effects from phenytoin
• can make Nuvigil less effective
propranolol (Inderal LA, InnoPran XL)can increase the risk of side effects from propranolol
warfarin (Jantoven)can make warfarin less effective

Certain health conditions or other factors could raise your risk of harm if you take Nuvigil. In such cases, your doctor may not prescribe Nuvigil for you. These are known as contraindications. A contraindication of Nuvigil is:

If you’ve had an allergic reaction: If you’ve had an allergic reaction to Nuvigil or any of its ingredients, your doctor likely won’t prescribe Nuvigil for you. This is because taking the drug could cause another allergic reaction. Ask your doctor about other treatments that may be better options for you.

Before you start taking Nuvigil, talk with your doctor if this contraindication applies to you. Your doctor can determine whether Nuvigil is safe for you to take.

You should not take Nuvigil with alcohol, according to the drugmaker. The effects of alcohol during treatment with Nuvigil haven’t been studied.

Doctors prescribe Nuvigil to improve wakefulness in adults who have excessive sleepiness caused by certain conditions. Alcohol can cause sleepiness. So drinking alcohol while taking Nuvigil may make it more difficult to improve wakefulness. It also can make it harder to determine whether Nuvigil is working to treat your condition.

If you drink alcohol and have questions about consuming it while taking Nuvigil, talk with your doctor or pharmacist.

Learn more about certain drug interactions that can occur with Nuvigil.

Interaction with hormonal birth control medications

Nuvigil can interact with hormonal birth control medications, which help prevent pregnancy. Hormonal birth control also helps treat acne and endometriosis.

Examples of hormonal birth control medications include:

  • ethinyl estradiol/norelgestromin (Onsura, Xulane)
  • ethinyl estradiol/norethindrone (Aranelle, others)
  • elagolix/estradiol/norethindrone acetate (Oriahnn)
  • Mirena (levonorgestrel-releasing intrauterine system)
  • medroxyprogesterone (Depo-Provera)

What could happen

Taking Nuvigil with hormonal birth control medications can make the hormonal birth control less effective. This effect can continue for at least 1 month after your last dose of Nuvigil.

What you can do

Your doctor likely will suggest using a different or backup form of birth control while you’re taking Nuvigil. It likely will be one that is not hormonal-based. Examples include condoms, a diaphragm, and the copper intrauterine device (Paragard).

If you have questions about taking Nuvigil with hormonal birth control, talk with your doctor or pharmacist.

Interaction with cobicistat and medications that contain it

Nuvigil can interact with cobicistat (Tybost) and medications that contain it. These medications help treat HIV.

Examples of medications that contain cobicistat include:

  • Stribild (elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate)
  • Evotaz (atazanavir/cobicistat)
  • Prezcobix (darunavir/cobicistat)
  • Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide)
  • Symtuza (darunavir/cobicistat/emtricitabine/tenofovir alafenamide)

What could happen

Taking Nuvigil with a medication that contains cobicistat may:

  • make the medication containing cobicistat less effective, which can also increase the risk of resistance to the medication and its ingredients
  • increase your risk of side effects from Nuvigil because cobicistat blocks certain proteins that break down and clear Nuvigil after you take a dose

What you can do

Due to these risks, your doctor likely will avoid prescribing Nuvigil with a medication that contains cobicistat. Instead, they can recommend an alternative to Nuvigil or the other medication.

Nuvigil may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other interactions possible with Nuvigil.

Does Nuvigil interact with supplements?

Before you start taking Nuvigil, talk with your doctor and pharmacist about any herbs or vitamins and supplements you take. Sharing this information with them may help you avoid possible interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Nuvigil interactions with herbs

Nuvigil currently has no reports of interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Nuvigil.

Nuvigil interactions with vitamins

Nuvigil currently has no reports of interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Nuvigil.

Nuvigil interactions with caffeine supplements

In addition to the interactions just described, Nuvigil can interact with supplements that contain caffeine. Examples include caffeine tablets, certain energy drinks, and certain pre-workout supplements. Combining caffeine supplements and Nuvigil can increase the risk of certain side effects. Examples are irritability, nervousness, and insomnia.

Before taking Nuvigil, talk with your doctor about consuming products that contain caffeine during treatment.

Does Nuvigil interact with food?

Nuvigil can interact with foods or beverages that contain caffeine. Examples include coffee, chocolate, and green tea. Combining caffeine and Nuvigil can increase the risk of certain side effects. Examples are irritability, nervousness, and insomnia.

Because of this risk, ask your doctor about foods or beverages you should avoid or limit while taking Nuvigil.

Does Nuvigil interact with vaccines?

Nuvigil currently has no reports of interacting with vaccines. If you have questions about getting certain vaccines during your Nuvigil treatment, talk with your doctor.

Does Nuvigil interact with lab tests?

Nuvigil currently has no reports of interacting with lab tests. If you have questions about having certain lab tests during your treatment with Nuvigil, talk with the healthcare professional ordering the test.

Does Nuvigil interact with cannabis or CBD?

Nuvigil currently has no reports of interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Nuvigil.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions or other health factors may raise the risk of interactions with Nuvigil. Before taking Nuvigil, talk with your doctor about your health history. They’ll determine whether Nuvigil is right for you.

Health conditions or other factors that might interact with Nuvigil include:

Heart problem, including high blood pressure or past heart attack: Side effects related to the heart were reported in studies of Nuvigil. If you have an existing heart problem, you may be at higher risk of these side effects. Taking Nuvigil could also worsen symptoms of your heart condition.

Examples of heart conditions include high blood pressure or a past heart attack. Depending on your specific heart condition, your doctor may prescribe a treatment other than Nuvigil that’s safer for you.

Liver condition: If you have a severe liver condition, your doctor may prescribe a lowered Nuvigil dosage for you. If your liver function is severely impaired, your body may not clear Nuvigil as well as usual. This could increase the amount of the drug in your body. And in turn, that can raise your risk of side effects such as insomnia.

Mental health condition, such as depression: Rarely, Nuvigil may cause or worsen symptoms of certain mental health conditions. Examples include depression and suicidal thoughts. If you have a mental health condition, taking Nuvigil could worsen its symptoms.

Substance use disorder: Nuvigil is a controlled substance and carries some risk of misuse and dependence. A controlled substance is a drug the government regulates due to the risk of dependence or misuse. Misuse refers to taking a drug in a way other than how a doctor prescribes it. With dependence, your body needs the drug to feel like it usually does.

If you have substance use disorder, your risk of misuse and dependence while taking Nuvigil may increase. An example of this disorder is opioid use disorder. Your doctor can review with you the risks and benefits of taking Nuvigil.

Pregnancy: It’s not known whether Nuvigil is safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before taking Nuvigil.

Breastfeeding: It’s not known whether it’s safe to take Nuvigil while breastfeeding. It’s not known whether the drug passes into breast milk. It’s also not known whether the drug may cause side effects in a child who’s breastfed. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.

Allergic reaction: If you’ve had an allergic reaction to Nuvigil or any of its ingredients, your doctor likely won’t prescribe Nuvigil. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.

Help is out there

If you or someone you know is in crisis and considering suicide or self-harm, please seek support:

If you’re calling on behalf of someone else, stay with them until help arrives. You may remove weapons or substances that can cause harm if you can do so safely.

If you are not in the same household, stay on the phone with them until help arrives.

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Find answers to some frequently asked questions about Nuvigil and possible interactions.

How do the interactions of Nuvigil vs. Provigil compare?

Nuvigil and Provigil have similar interactions. Nuvigil and Provigil treat the same conditions, and their active ingredients are similar. (Nuvigil contains the active ingredient armodafinil, while Provigil contains modafinil.)

Both Nuvigil and Provigil interact with the following drugs, to name a few:

Talk with your doctor or pharmacist if you’d like to learn more about how Provigil and Nuvigil compare.

Do Nuvigil and Adderall have similar interactions?

Yes, Nuvigil and Adderall are stimulant drugs with some similar interactions. Some drugs that interact with both Nuvigil and Adderall include some monoamine oxidase inhibitors (MAOIs) and omeprazole (Prilosec).

Both drugs also have different interactions. For example:

  • Nuvigil may interact with cyclosporine (Gengraf, Neoral, Sandimmune), which is not known to interact with Adderall.
  • Adderall may interact with antacids such as calcium carbonate (Tums), which are not known to interact with Nuvigil.

Your doctor or pharmacist can answer additional questions you may have about how Nuvigil and Adderall compare.

Taking certain steps can help you avoid interactions with Nuvigil. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:

  • whether you drink alcohol or use cannabis
  • other medications you take, as well as any vitamins, supplements, and herbs (they can also help you fill out a medication list)
  • what to do if you start taking a new drug during your Nuvigil treatment

It’s also important to understand Nuvigil’s label and other paperwork that may come with the drug. Colored stickers that describe interactions may be on the label. And the paperwork (sometimes called the patient package insert or medication guide) may have other details about interactions. (If you did not get paperwork with Nuvigil, ask your pharmacist to print a copy for you.)

If you have difficulty reading or understanding this information, your doctor or pharmacist can help.

Taking Nuvigil exactly as prescribed also can help prevent interactions.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.