Nubeqa (darolutamide) is a prescription drug that’s used to treat specific types of prostate cancer. The drug comes as an oral tablet that you take twice per day.

Nubeqa is prescribed to adults to treat specific types of prostate cancer. These are:

* If you’ve had surgery to remove both testicles, you’ll take Nubeqa alone. But if you haven’t had this surgery, you’ll take Nubeqa with a gonadotropin-releasing hormone therapy.
† Metastatic means the cancer has spread to other areas outside the prostate.

The active ingredient in Nubeqa is darolutamide. (An active ingredient is what makes a drug work.) Nubeqa belongs to a group of drugs called androgen receptor blockers.

This article describes the dosage of Nubeqa, as well as its strength and how to take it. To learn more about Nubeqa, see this in-depth article.

This section describes the usual dosage of Nubeqa. Keep reading to learn more.

What is Nubeqa’s form?

Nubeqa is available as an oral tablet.

What strength does Nubeqa come in?

Nubeqa comes in one strength of 300 milligrams (mg).

What is the usual dosage of Nubeqa?

The information below describes the dosage that’s commonly taken or recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosage for prostate cancer

The usual Nubeqa dosage for adults with prostate cancer is 600 mg twice per day.

For nonmetastatic castration-resistant prostate cancer, you’ll take Nubeqa alone if you’ve had surgery to remove both testicles. But if you haven’t had this surgery, you’ll take Nubeqa with a gonadotropin-releasing hormone therapy.

For metastatic hormone-sensitive prostate cancer, you’ll likely also take docetaxel with Nubeqa. You’ll receive your first of six cycles (rounds) of docetaxel within 6 weeks after starting Nubeqa.

If you have questions about your dosage of Nubeqa, talk with your doctor.

Is Nubeqa taken long term?

Yes, Nubeqa is usually taken as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.

Dosage adjustments

In certain cases, you may need a dosage adjustment for Nubeqa.

If you have moderate liver problems, your doctor will reduce your dose of Nubeqa. You’ll likely take 300 mg of Nubeqa twice per day. It’s not known whether Nubeqa is safe to take if you have severe liver disease.

You also may need a dosage adjustment for Nubeqa if you have severe kidney disease. In this case, your doctor will lower your dosage to 300 mg twice per day. It’s not known whether Nubeqa is safe to take if you have end stage renal disease.

If you have questions about dosage adjustments you may need with Nubeqa treatment, ask your doctor.

The dosage of Nubeqa your doctor prescribes may depend on other conditions you have. See the “Dosage adjustments” section above for more information.

Nubeqa is available as an oral tablet that you swallow twice per day. You’ll take Nubeqa with food around the same time each day. This helps keep a steady level of Nubeqa in your body to treat your condition.

Avoid consuming grapefruit and grapefruit juice during treatment with Nubeqa. This is because grapefruit can interact with Nubeqa and increase your risk of side effects.

Swallow Nubeqa tablets whole. Do not cut, chew, or crush them. If you have difficulty swallowing tablets, see this article for tips on how to take this form of medication.

For information on the expiration, storage, and disposal of Nubeqa, talk with your doctor or pharmacist.

Accessible drug containers and labels

Some pharmacies provide medication labels that:

  • have large print
  • use braille
  • feature a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

Let your pharmacist know if you have difficulty opening medication bottles. They may have tips to help, or they may be able to supply Nubeqa in an easy-open container.

If you miss a dose of Nubeqa, take it as soon as you remember. But do not double up the medication by taking two doses of Nubeqa at the same time. This can increase your risk of side effects from the medication.

If you’re not sure whether you should take a missed dose, talk with your doctor or pharmacist.

To help you remember to take your dose of Nubeqa on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Do not take more Nubeqa than your doctor prescribes, as this can lead to harmful effects.

What to do in case you take too much Nubeqa

Call your doctor right away if you think you’ve taken too much Nubeqa. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Below are answers to some commonly asked questions about Nubeqa’s dosage.

How long does it take for Nubeqa to start working?

Nubeqa is prescribed to treat specific types of prostate cancer. To grow, prostate cancer needs the hormone testosterone. So Nubeqa works by blocking the effects of testosterone to help slow the growth of the cancer.

Because of how the drug works, you likely won’t feel the drug working in your body. But your doctor will monitor you during treatment to check whether the drug is slowing cancer growth. If Nubeqa isn’t working for you, they’ll suggest other treatment options.

If you have other questions about what to expect from your Nubeqa treatment, talk with your doctor.

Can Nubeqa be taken for other forms of cancer? If so, what’s the dosage?

No, Nubeqa is not taken or approved for other forms of cancer. The drug is approved to treat only specific types of prostate cancer. It works to block the hormone testosterone to slow the growth of prostate cancer.

The types of prostate cancer Nubeqa treats are:

* If you’ve had surgery to remove both testicles, you’ll take Nubeqa alone. But if you haven’t had this surgery, you’ll take Nubeqa with a gonadotropin-releasing hormone therapy.
† Metastatic means the cancer has spread to other areas outside the prostate.

Because Nubeqa isn’t taken for other types of cancer, the drugmaker provides recommended dosages only for its approved uses.

Your doctor will be able to suggest treatments for other forms of cancer.

The sections above describe the usual dosage provided by the drugmaker. If your doctor recommends Nubeqa for you, they’ll prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Nubeqa without your doctor’s recommendation. Only take Nubeqa exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • Would I need a dosage adjustment for Nubeqa if I’m taking other cancer medications?
  • Could you prescribe a lower dose of Nubeqa if I experience side effects?
  • How does the dosage of Nubeqa compare with the dosage of enzalutamide (Xtandi)?

To learn more about Nubeqa, see this “All About Nubeqa” article.

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.