Nexlizet (bempedoic acid/ezetimibe) is prescribed to lower LDL cholesterol in people with heart disease or a certain inherited condition. The drug comes as a tablet that you swallow, usually once per day.

Nexlizet is prescribed to adults to lower LDL-C cholesterol* (“bad cholesterol”) if they also have:

* Doctors commonly refer to “LDL-C” as “LDL” (low-density lipoprotein).

Doctors usually prescribe Nexlizet together with a statin drug and a low fat diet.

The active ingredients in Nexlizet are bempedoic acid and ezetimibe. (An active ingredient is what makes a drug work.) Bempedoic acid belongs to a group of drugs called adenosine triphosphate-citrate lyase inhibitors. Ezetimibe belongs to a group of drugs called cholesterol absorption inhibitors.

Nexlizet is available as an oral tablet.

This article describes the dosage of Nexlizet, as well as its strength and how to take it. To learn more about Nexlizet, see this in-depth article.

This section describes the usual dosage of Nexlizet. Keep reading to learn more.

What is Nexlizet’s form?

Nexlizet is available as an oral tablet.

What strength does Nexlizet come in?

Nexlizet comes in one strength. Each tablet contains 180 mg bempedoic acid and 10 mg ezetimibe.

What is the usual dosage of Nexlizet?

The information below describes the dosage that is commonly taken or recommended. But be sure to follow the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosage for lowering cholesterol

Nexlizet helps lower LDL-C cholesterol (“bad cholesterol”) if you also have:

For either condition, the usual Nexlizet dosage is one tablet once per day. Each tablet contains 180 mg bempedoic acid and 10 mg ezetimibe.

Doctors usually prescribe Nexlizet together with a statin drug and a low fat diet.

Is Nexlizet taken long term?

Yes, Nexlizet is usually a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.

The dosage of Nexlizet your doctor prescribes may depend on several factors. These include:

  • the type and severity of the condition you’re taking the drug to treat
  • your age

Nexlizet may increase your uric acid level. This increase could cause gout, especially if you’ve had it before. If you have gout symptoms while taking Nexlizet, your doctor can recommend treatment.

While rare, you could experience tendon rupture* during Nexlizet treatment. You’re more prone to rupture a tendon in certain situations during treatment. These are:

  • if you’re over age 60 years
  • if you take certain drugs (such as corticosteroids or fluoroquinolone antibiotics)
  • if you have severe kidney problems
  • if you’ve ever had a ruptured tendon

* Tendon rupture is a partial or complete tear of a tendon, which is a type of tissue.

If you experience tendon rupture while taking Nexlizet, your doctor likely will recommend stopping Nexlizet immediately.

In some situations, your doctor likely will recommend that you should not take Nexlizet. These are:

In these situations, your doctor can recommend a different treatment option.

Nexlizet is available as an oral tablet. If you have difficulty swallowing tablets, see this article for tips on how to take this form of medication.

You may take Nexlizet with or without food, but you must swallow the tablet whole. Do not crush or chew it.

You may need to take your Nexlizet dose at a different time to certain other medications you take. One example is bile acid sequestrants such as colesevelam (Welchol). If you take this type of medication, you’ll likely need to take Nexlizet at least 2 hours before or 4 hours after taking it. Ask your doctor or pharmacist about spacing apart other medications from Nexlizet.

For information on the expiration, storage, and disposal of Nexlizet, talk with your doctor or pharmacist.

Accessible drug containers and labels

Some pharmacies provide medication labels that:

  • have large print
  • use braille
  • feature a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

Let your pharmacist know if you have difficulty opening medication bottles. They may have tips to help, or they may be able to supply Nexlizet in an easy-open container.

If you miss a dose of Nexlizet, talk with your doctor about whether to take it or skip it.

If you need help remembering to take your dose of Nexlizet on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Do not take more Nexlizet than your doctor prescribes, as this can lead to harmful effects.

What to do in case you take too much Nexlizet

Call your doctor right away if you think you’ve taken too much Nexlizet. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Below are answers to some commonly asked questions about Nexlizet’s dosage.

Is Nexlizet’s dosage similar to the dosages of statin drugs, such as simvastatin?

The forms and how often you take each drug are similar. Nexlizet and simvastatin (Zocor) are oral tablets that you take once per day. Simvastatin also comes in a liquid form (FloLipid).

Nexlizet is a combination of two active ingredients: bempedoic acid and ezetimibe. While simvastatin contains one active ingredient, it’s also available together with ezetimibe (Vytorin).

The dose in mg for each drug differs. Your doctor will prescribe the drug and the dosage that’s right for you.

To learn more about how these drugs compare, talk with your doctor.

How long does it take for Nexlizet to start working?

Because of how the drug works, you likely won’t feel Nexlizet working in your body. Blood tests may not show that your LDL-C cholesterol has lowered until you’ve taken Nexlizet for 2–3 months.

The drugmaker recommends that your doctor checks your cholesterol levels 8–12 weeks after starting Nexlizet. Your doctor also will monitor you during treatment to check whether the drug is working for your condition.

If you have other questions about what to expect from your Nexlizet treatment, talk with your doctor.

The sections above describe the usual dosage provided by the drugmaker. If your doctor recommends Nexlizet for you, they’ll prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Nexlizet without your doctor’s recommendation. Only take Nexlizet exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • Do you need to adjust my Nexlizet dosage if I’m taking other medications?
  • While taking Nexlizet, can I take other medications besides statin drugs to lower my cholesterol?
  • Does it matter what time of day I take my Nexlizet dose?

To learn more about Nexlizet, see this “All About Nexlizet” article.

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.