Myrbetriq (mirabegron) is a prescription drug that’s used to treat certain bladder problems. This drug can interact with other medications. For example, Myrbetriq can interact with metoprolol (Lopressor, Toprol XL, others) and diphenhydramine (Benadryl).
Myrbetriq is used in adults to treat overactive bladder (OAB) with symptoms of urinary urgency, incontinence, or frequency. The drug is also used in certain children with a type of OAB related to a problem with the nervous system.
Myrbetriq contains the active ingredient mirabegron. It comes in two extended-release* forms:
- oral tablets
- granules that a pharmacist mixes with water to form an oral suspension
An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.
Keep reading to learn about Myrbetriq’s possible interactions. And for more information about Myrbetriq, including details about its uses, see this article.
* “Extended release” means the drug is slowly released into your body over a long period of time.
Before you start taking Myrbetriq, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Myrbetriq interacts with herbs or vitamins and supplements, see the “Are there other interactions with Myrbetriq?” section.)
If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.
The table below lists drugs that may interact with Myrbetriq. Keep in mind that this table does not include all drugs that may interact with Myrbetriq. For more information about some of these interactions, see the “Drug interactions explained” section.
| Drug group or drug name | Drug examples | What can happen |
| certain beta-blockers | • metoprolol (Lopressor, Toprol XL, others) • carvedilol (Coreg, Coreg CR) • nebivolol (Bystolic) • propranolol (Hemangeol, Inderal LA, others) • timolol | can increase the risk of side effects from the beta-blocker |
| certain antihistamines | • chlorpheniramine • diphenhydramine (Benadryl) • promethazine (Promethegan) | can increase the risk of side effects from Myrbetriq or the antihistamine |
| certain selective serotonin reuptake inhibitors (SSRIs) | • fluoxetine (Prozac) • paroxetine (Brisdelle, Paxil) • sertraline (Zoloft) | can increase the risk of side effects from the SSRI |
| anticholinergics | • darifenacin • ipratropium (Atrovent HFA) • oxybutynin • tiotropium (Spiriva) | can increase the risk of side effects from Myrbetriq or the anticholinergic |
| tricyclic antidepressants (TCAs) | • amitriptyline • clomipramine (Anafranil) • desipramine (Norpramin) • doxepin (Silenor) • protriptyline | can increase the risk of side effects from Myrbetriq or the TCA |
| dextromethorphan (Delsym) | — | can increase the risk of side effects from dextromethorphan |
| digoxin (Lanoxin) | — | can increase the risk of side effects from digoxin |
| donepezil (Adlarity, Aricept) | — | can increase the risk of side effects from donepezil |
| warfarin (Jantoven) | — | can increase the risk of side effects from warfarin |
Certain health conditions or other factors could raise your risk of harm if you take Myrbetriq. In such cases, your doctor may not prescribe Myrbetriq for you. These are known as contraindications. The information below includes contraindications of Myrbetriq.
If you’ve had an allergic reaction: If you’ve had an allergic reaction to Myrbetriq or any of its ingredients, your doctor likely won’t prescribe Myrbetriq for you. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.
Before you start taking Myrbetriq, talk with your doctor if any of the factors above apply to you. Your doctor can tell you more about who should not take Myrbetriq and recommend whether the drug is safe for you.
Myrbetriq is not known to interact with alcohol.
But drinking alcohol may worsen symptoms of overactive bladder (OAB). (Myrbetriq is used to treat OAB.) So your doctor may recommend that you avoid or limit alcohol consumption during treatment with Myrbetriq.
If you have questions about consuming alcohol while taking Myrbetriq, talk with your doctor or pharmacist.
Learn more about certain drug interactions that can occur with Myrbetriq.
Interaction with certain beta-blockers
Myrbetriq can interact with certain beta-blockers, which are used to treat high blood pressure and other heart conditions.
Examples of beta-blockers that may interact with Myrbetriq include:
- metoprolol (Lopressor, Toprol XL, others)
- carvedilol (Coreg, Coreg CR)
- nebivolol (Bystolic)
- propranolol (Hemangeol, Inderal LA, others)
- timolol
What could happen
Taking Myrbetriq with certain beta-blockers can raise your risk of side effects from the beta-blocker. Examples include low blood pressure and slow heart rate.
This is because Myrbetriq may slow the breakdown of these drugs in your body. This can lead to a high level of the beta-blocker in your system, which may increase your risk of side effects.
What you can do
If you take Myrbetriq with a beta-blocker, your doctor may check your blood pressure and heart rate more often than usual. They’ll review your readings for these factors and decide whether to adjust your beta-blocker dosage. You should not take a higher dose of either medication than your doctor prescribes.
If you have questions about taking Myrbetriq with a beta-blocker, talk with your doctor or pharmacist.
Interaction with certain antihistamines
Myrbetriq can interact with certain antihistamines, which are used to ease allergy symptoms.
Examples of antihistamines that may interact with Myrbetriq include:
- chlorpheniramine
- diphenhydramine (Benadryl)
- promethazine (Promethegan)
What could happen
Taking Myrbetriq with certain antihistamines can raise your risk of side effects from either drug. This is because Myrbetriq may cause your body to break down certain antihistamines more slowly than usual. This can lead to a high level of the antihistamine in your system, which could increase your risk of side effects.
Myrbetriq and antihistamines can also cause urinary retention as a side effect. So taking these drugs together can raise your risk of this side effect.
What you can do
Before taking an antihistamine with Myrbetriq, talk with your doctor or pharmacist. They can advise you on whether these drugs are safe to take together. If needed, they can recommend the appropriate doses or a different treatment for allergy symptoms.
If you have questions about taking Myrbetriq with an antihistamine, talk with your doctor or pharmacist.
Interaction with dextromethorphan
Myrbetriq can interact with dextromethorphan (Delsym), which is used to relieve cough.
What could happen
Taking these drugs together can raise your risk of side effects from dextromethorphan. Examples include drowsiness, nausea, and tremor.
This is because Myrbetriq may slow the breakdown of dextromethorphan in your system. This can lead to a high level of dextromethorphan in your body, which may increase your risk of side effects.
What you can do
Before taking Myrbetriq with dextromethorphan, talk with your doctor or pharmacist. They can advise you on whether it’s safe to take these medications together. If needed, they can recommend the appropriate doses or a different treatment to relieve cough.
If you have questions about taking Myrbetriq with dextromethorphan, talk with your doctor or pharmacist.
Myrbetriq may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that this information does not include all other possible interactions with Myrbetriq.
Does Myrbetriq interact with supplements?
Before you start taking Myrbetriq, talk with your doctor and pharmacist about any herbs or vitamins and supplements you take. Sharing this information with them may help you avoid possible interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Myrbetriq and herbs
There are currently no reports of Myrbetriq interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.
For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Myrbetriq.
Myrbetriq and vitamins
There are currently no reports of Myrbetriq interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.
For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products with Myrbetriq.
Does Myrbetriq interact with food?
There are currently no reports of Myrbetriq interacting with food. If you have questions about eating certain foods during your treatment with Myrbetriq, talk with your doctor.
Does Myrbetriq interact with vaccines?
There are currently no reports of Myrbetriq interacting with vaccines. If you have questions about getting certain vaccines during your Myrbetriq treatment, talk with your doctor.
Does Myrbetriq interact with lab tests?
There are currently no reports of Myrbetriq interacting with lab tests. If you have questions about having certain lab tests during your treatment with Myrbetriq, talk with the healthcare professional ordering the test.
Does Myrbetriq interact with cannabis or CBD?There are currently no reports of Myrbetriq interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Myrbetriq.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Certain medical conditions or other health factors may raise the risk of interactions with Myrbetriq. Before taking Myrbetriq, talk with your doctor about your health history. They’ll determine whether Myrbetriq is right for you.
Health conditions or other factors that might interact with Myrbetriq include:
Liver or kidney problems. Before taking Myrbetriq, tell your doctor if you have a liver or kidney problem. Examples include liver failure and kidney failure. Your doctor may prescribe a lower dosage of Myrbetriq for you.
High blood pressure. If you have high blood pressure that isn’t well managed, talk with your doctor before taking Myrbetriq. The drug may cause high blood pressure, which could worsen this condition. Your doctor can advise you on whether Myrbetriq is a safe treatment option for you.
Bladder outlet obstruction. Myrbetriq may cause urinary retention in certain people with bladder outlet obstruction. Before taking Myrbetriq, tell your doctor if you have this condition. They’ll determine whether it’s safe to prescribe Myrbetriq for you.
Pregnancy. It’s not known whether Myrbetriq is safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before taking Myrbetriq.
Breastfeeding. It’s not known whether it’s safe to take Myrbetriq while breastfeeding or if the drug passes into breast milk. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.
Allergic reaction. If you’ve had an allergic reaction to Myrbetriq or any of its ingredients, your doctor will likely not prescribe Myrbetriq. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.
Find answers to some frequently asked questions about Myrbetriq and possible interactions.
Can you take Myrbetriq with antibiotics?
Yes, you may take Myrbetriq with antibiotics. There are no known interactions between these drugs.
Antibiotics are used to treat bacterial infections, such as urinary tract infections (UTIs). (UTI is a common side effect of Myrbetriq.) If you have a UTI or other bacterial infection during Myrbetriq treatment, your doctor may prescribe an antibiotic to treat it.
If you have other questions about taking Myrbetriq and antibiotics together, talk with your doctor or pharmacist.
Can Myrbetriq and metformin be taken together?
Yes, if your doctor tells you it’s safe. Myrbetriq and metformin (Fortamet, Glumetza) aren’t known to interact with each other.
Metformin is used to treat type 2 diabetes. Symptoms of diabetes may include urinary incontinence or frequency, which can also be symptoms of overactive bladder (OAB). (Myrbetriq is used to treat OAB.)
If you have symptoms of urinary incontinence or frequency, talk with your doctor. They can help determine whether your symptoms may be related to diabetes, OAB, or another cause. Your doctor will decide whether you should take metformin with Myrbetriq.
If you have other questions about taking Myrbetriq with metformin, talk with your doctor or pharmacist.
Taking certain steps can help you avoid interactions with Myrbetriq. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:
- whether you drink alcohol or use cannabis
- other medications you take, as well as any vitamins, supplements, and herbs (they can also help you fill out a
medication list ) - what to do if you start taking a new drug during your Myrbetriq treatment
It’s also important to understand Myrbetriq’s
If you have trouble reading or understanding this information, your doctor or pharmacist can help.
Taking Myrbetriq exactly as prescribed can also help prevent interactions.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.