Motegrity (prucalopride) is a prescription drug used to treat chronic idiopathic constipation. The drug comes as a tablet you swallow. It’s usually taken once per day.

Motegrity is used in adults to treat chronic idiopathic constipation. This type of constipation lasts 3 months or more and isn’t related to another medical condition.

The active ingredient in Motegrity is prucalopride. An active ingredient is what makes a drug work. Motegrity belongs to a group of drugs called serotonin-4 (5HT-4) receptor agonists.

This article describes the dosages of Motegrity, as well as its strengths and how to take it. To learn more about Motegrity, see this in-depth article.

The table below highlights the basics of Motegrity’s dosage. All doses are listed in milligrams (mg).

Who Motegrity is prescribed forRecommended dosage
adults 2 mg once per day
adults with severe kidney disease1 mg once per day

Keep reading for more details about Motegrity’s dosage.

What is Motegrity’s form?

Motegrity is available as an oral tablet.

What strengths does Motegrity come in?

Motegrity comes in two strengths: 1 mg and 2 mg.

What are the usual dosages of Motegrity?

The information below describes dosages that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosage for chronic idiopathic constipation

The typical Motegrity dosage for adults with chronic idiopathic constipation is 2 mg once per day. This is also the maximum dosage based on studies. Your dose can be taken with or without food.

Is Motegrity used long term?

Sometimes. If you and your doctor determine that it’s safe and effective for your condition, you may take it long term.

Dosage adjustments

Your doctor may adjust your dose of Motegrity based on your kidney function. If you have severe kidney disease, your doctor will likely recommend a lower dose of Motegrity. But if you require dialysis, your doctor may recommend a different treatment option.

The dosage of Motegrity you’re prescribed may depend on several factors. These include:

  • the severity of the condition you’re taking the drug to treat
  • your age
  • other conditions you may have (see the “Dosage adjustments” section above)

Motegrity comes as an oral tablet. If you have trouble swallowing tablets, see this article for tips on how to take this form of medication.

For information on the expiration, storage, and disposal of Motegrity, talk with your doctor or pharmacist.

Accessible drug containers and labels

Some pharmacies provide medication labels that:

  • have large print
  • use braille
  • feature a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

Let your pharmacist know if you have trouble opening medication bottles. They may have tips to help, or they may be able to supply Motegrity in an easy-open container.

If you miss a dose of Motegrity, take it as soon as you remember. But if it’s almost time for your next dose, skip the missed dose and take your next dose at its usual time. If you’re not sure whether you should take a missed dose, talk with your doctor or pharmacist.

If you need help remembering to take your dose of Motegrity on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Do not take more Motegrity than your doctor prescribes, as this can lead to harmful effects.

Symptoms of overdose

Symptoms caused by an overdose can include:

  • headache
  • nausea
  • diarrhea

What to do in case you take too much Motegrity

Call your doctor right away if you think you’ve taken too much Motegrity. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Below are answers to some commonly asked questions about Motegrity’s dosage.

How long does it take for Motegrity to start working?

Motegrity starts to work after your first dose. In studies, many people noticed Motegrity starting to work within a day. But many people had a complete bowel movement within a few days.

Your doctor will monitor you during treatment to check whether the drug is working well to treat your condition.

If you have other questions about what to expect from your Motegrity treatment, talk with your doctor.

Can Motegrity be used for gastroparesis? If so, what’s the dosage?

Gastroparesis occurs when it takes longer than normal for food to move from your stomach to your intestines. Motegrity is not approved for gastroparesis. But in some cases your doctor may prescribe it off-label for this condition. (Off-label use is when a drug is used to treat a condition other than those it’s approved for.)

Motegrity may help with gastroparesis management based on this study. But another study found that taking this drug for gastroparesis may increase your risk of side effects.

Because Motegrity isn’t approved to treat gastroparesis, the drug manufacturer doesn’t provide recommended dosages for this condition. If your doctor recommends this drug, they’ll prescribe the dosage that’s right for you.

To learn more about your treatment options for gastroparesis, including Motegrity, talk with your doctor.

The sections above describe the usual dosages provided by the manufacturer. If your doctor recommends Motegrity, they’ll prescribe the dosage that’s right for you. Remember, you should not change your dosage of Motegrity without their recommendation. Only take this drug exactly as prescribed.

Talk with your doctor if you have questions or concerns about your current dosage. Here are some examples of questions you may want to ask:

To learn more about Motegrity, see these articles:

To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters. You may also want to check out the online communities at Bezzy. It’s a place where people with certain conditions can find support and connect with others.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.