Lucemyra (lofexidine) is a prescription drug that’s taken to treat opioid withdrawal symptoms. The drug comes as an oral tablet that you take four times per day.

Lucemyra is used in adults to manage opioid withdrawal symptoms. You may experience withdrawal symptoms if your body has become dependent* on opioid medications. Lucemyra isn’t a treatment for opioid use disorder.

The active ingredient in Lucemyra is lofexidine. (An active ingredient is what makes a drug work.)

Lucemyra belongs to a group of drugs called alpha-2 adrenergic agonists.

This article describes the dosage of Lucemyra, as well as its strength and how to take it. To learn more about Lucemyra, see this in-depth article.

* With dependence, your body needs the drug to function as usual.

This section describes the usual dosages of Lucemyra. Keep reading to learn more.

What is Lucemyra’s form?

Lucemyra is available as an oral tablet.

What strength does Lucemyra come in?

Lucemyra comes in one strength of 0.18 milligrams (mg).

What are the usual dosages of Lucemyra?

Your doctor will likely start you on the recommended dosage of Lucemyra. They’ll prescribe the smallest dosage that provides the desired effect.

The information below describes the dosage that’s commonly recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosage for opioid withdrawal symptoms

The typical Lucemyra dosage for adults with opioid withdrawal symptoms is three tablets to be taken four times per day. (In other words, you’ll take 0.54 mg four times per day.) Usually, you take this dosage for the first 5–7 days after stopping an opioid medication.

Your doctor will adjust your dosage based on your response to Lucemyra. They also may adjust it based on your risk of side effects from the medication.

Your treatment may continue for up to 14 days based on your symptoms.

To stop treatment, your doctor will slowly reduce your doses of Lucemyra. For more information about this, see the “Lucemyra and withdrawal and dependence” section below.

Lucemyra has a maximum dose and a maximum daily dosage:

  • Dose: Do not take more than 4 tablets of Lucemyra in one dose. (This means the maximum dose is 0.72 mg.)
  • Daily dosage: Do not take more than 16 tablets of Lucemyra in one day. (This means the maximum dosage is 2.88 mg per day.)

Talk with your doctor if you have questions about Lucemyra’s dosage.

Is Lucemyra taken long term?

No, Lucemyra is taken only up to 14 days to ease opioid withdrawal symptoms. It’s not taken for long-term treatment. If you have questions about how long you’ll take Lucemyra, talk with your doctor.

Dosage adjustments

In certain cases, you may need dosage adjustments for Lucemyra.

If you have liver problems, your doctor will adjust your dosage of Lucemyra. The adjustment depends on whether you have mild, moderate, or severe liver disease.

Similarly, if you have kidney problems, your doctor will adjust your dosage of Lucemyra. The adjustment depends on whether you:

If you have questions about whether you need dosage adjustments for Lucemyra, talk with your doctor.

The dosage of Lucemyra your doctor prescribes may depend on several factors. These include:

  • the severity of your opioid withdrawal symptoms
  • other medications you may be taking
  • other conditions you may have (see the “Dosage adjustments” section above)

You’ll swallow Lucemyra oral tablet with or without food. But be sure to stay hydrated and avoid becoming overheated while taking the medication. This will help you avoid low blood pressure and fainting.

If you have difficulty swallowing tablets, see this article for tips on how to take this form of medication.

When you first start Lucemyra, you may experience some symptoms when you stand up from resting. These are:

  • low blood pressure
  • dizziness
  • lightheadedness
  • faintness

Call your doctor’s office if you have any of these symptoms. They’ll guide you on what you should watch out for and whether you can continue Lucemyra. To help you avoid fainting, be careful when you stand up from resting.

For information on the expiration, storage, and disposal of Lucemyra, talk with your doctor or pharmacist.

Accessible drug containers and labels

Some pharmacies provide medication labels that:

  • have large print
  • use braille
  • feature a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

Let your pharmacist know if you have difficulty opening medication bottles. They may have tips to help, or they may be able to supply Lucemyra in an easy-open container.

If you miss a dose of Lucemyra, take it as soon as you remember. But if it’s almost time for your next dose, skip the missed dose and take your next dose at its usual time. Take Lucemyra doses 5–6 hours apart and not sooner. Taking Lucemyra too often can increase your risk of serious side effects.

If you’re not sure whether you should take a missed dose, talk with your doctor or pharmacist.

If you need help remembering to take your dose of Lucemyra on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Do not take more Lucemyra than your doctor prescribes, as this can lead to harmful effects.

Symptoms of overdose

Symptoms caused by an overdose can include:

What to do in case you take too much Lucemyra

Call your doctor right away if you think you’ve taken too much Lucemyra. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

If you suddenly stop taking Lucemyra, you may experience withdrawal symptoms. These side effects can occur when you stop taking a drug on which your body has become dependent. (Dependence means your body needs the drug to function as usual.)

Examples of withdrawal symptoms include:

  • diarrhea
  • anxiety
  • sweating
  • chills
  • insomnia (trouble sleeping)
  • sudden increase in blood pressure
  • pain in extremities

Before you end your Lucemyra treatment, your doctor will lower your dosage slowly over 2–4 days. To do this, each day, they might reduce the number of tablets you take in your dose. This will continue until you stop Lucemyra completely. This gradual tapering of your dose can help reduce your risk of withdrawal symptoms after you stop treatment.

If you have questions about your dose and the dosing schedule to stop Lucemyra, talk with your doctor.

Below are answers to some commonly asked questions about Lucemyra’s dosage.

Is Lucemyra’s dosage similar to the dosages of clonidine?

No, their dosages differ. Both Lucemyra (lofexidine) and clonidine belong to the alpha-2 adrenergic agonist group of drugs. But they have differences in forms and dosages.

Lucemyra is approved to treat opioid withdrawal symptoms and comes in one strength as oral tablets.

Some doctors prescribe clonidine for opioid withdrawal symptoms as an off-label use. (With off-label use, doctors prescribe a drug for a purpose other than its approved uses.) Clonidine comes in several forms and strengths. The form and dosage of clonidine depend on the severity of your condition and other factors.

Your doctor will prescribe the drug and the dosage that’s right for you.

To learn more about how these drugs compare, talk with your doctor.

How long does it take for Lucemyra to start working?

Lucemyra starts to work soon after you take your first dose. This also depends on the severity of your opioid withdrawal symptoms and other individual factors.

When you feel a reduction in your withdrawal symptoms, you’ll know it’s working. Your doctor may adjust your dosage of Lucemyra to fit your needs. They’ll also monitor you during treatment to check whether the drug is working for your condition.

If you have questions about what to expect from your Lucemyra treatment, talk with your doctor.

The sections above describe the usual dosages provided by the drugmaker. If your doctor recommends Lucemyra for you, they’ll prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Lucemyra without your doctor’s recommendation. Only take Lucemyra exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • As I begin to have fewer withdrawal symptoms, can you lower my dosage of Lucemyra?
  • Will I experience more side effects if I take the highest dosage of Lucemyra?
  • If I’m taking other medications for opioid withdrawal symptoms, will I need a dosage adjustment of Lucemyra?

To learn more about Lucemyra, see this “Lucemyra (lofexidine)” article.

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.