Latuda (lurasidone) is a prescription drug that’s prescribed to treat schizophrenia and bipolar disorder. Latuda comes as a tablet that you take by mouth.
Latuda is prescribed to adults, adolescents, and some children to treat:
To learn more about Latuda’s uses, see the “What is Latuda used for?” section below.
Latuda contains the active ingredient lurasidone. (An active ingredient is what makes a drug work.)
Like most drugs, Latuda may cause mild or serious side effects. The lists below describe some of the more common side effects that Latuda may cause. These lists don’t include all possible side effects.
Keep in mind that side effects of a drug can depend on:
- your age
- other health conditions you have
- other medications you may be taking
Your doctor or pharmacist can tell you more about the potential side effects of Latuda. They can also suggest ways to help reduce side effects. For more details, you can see this article.
Mild side effects
Here’s a list of some of the mild side effects that Latuda can cause. To learn about other mild side effects, talk with your doctor or pharmacist, or read Latuda’s prescribing information.
Mild side effects of Latuda that have been reported include:
- weight gain
- akathisia (a movement disorder with restlessness)
- extrapyramidal symptoms (a disorder that causes symptoms, such as muscle contractions, restlessness, muscle rigidity, and tremor)
- mild allergic reaction*
Mild side effects of many drugs may go away within a few days or a couple of weeks. But if they become bothersome, talk with your doctor or pharmacist.
* To learn more about this side effect, see the “Allergic reaction” section below.
Serious side effects
Serious side effects from Latuda can occur, but they aren’t common. If you have serious side effects from Latuda, call your doctor right away. But if you think you’re having a medical emergency, you should call 911 or your local emergency number.
Serious side effects of Latuda that have been reported include:
- sexual side effects, including:
- erectile dysfunction (inability to have or maintain an erection)
- priapism (a painful erection that lasts for hours)
- changes in moods, such as feeling:
- tardive dyskinesia (a movement disorder)
- high blood sugar level and diabetes
- high blood levels of cholesterol and triglycerides (types of fat)
- high level of the hormone prolactin
- neuroleptic malignant syndrome (NMS), which is a rare but possibly life threatening condition
- low levels of white blood cells
- low blood pressure, which may lead to dizziness or fainting
- problems managing your body temperature, which could lead you to feel too warm
- problems swallowing
- suicidal thoughts and behaviors in children, adolescents, and young adults
- severe allergic reaction†
* For more information, see the “What should be considered before taking Latuda?” section.
† To learn more about this side effect, see the “Allergic reaction” section below.
Some people may have an allergic reaction to Latuda.
Symptoms of a mild allergic reaction can include:
A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing.
Call your doctor right away if you have an allergic reaction to Latuda. But if you think you’re having a medical emergency, call 911 or your local emergency number.
Help is out there
If you or someone you know is in crisis and considering suicide or self-harm, please seek support:
- Call the 988 Suicide and Crisis Lifeline at 988.
- Text HOME to the Crisis Textline at 741741.
- Not in the United States? Find a helpline in your country with Befrienders Worldwide.
- Call 911 or your local emergency services number if you feel safe to do so.
If you’re calling on behalf of someone else, stay with them until help arrives. You may remove weapons or substances that can cause harm if you can do so safely.
If you are not in the same household, stay on the phone with them until help arrives.
Your doctor will recommend the dosage of Latuda that’s right for you. Below are commonly used dosages, but always take the dosage your doctor prescribes.
Form and strengths
Latuda comes as tablets that you’ll take by mouth. It’s available in these strengths:
- 20 milligrams (mg)
- 40 mg
- 60 mg
- 80 mg
- 120 mg
Depending on the reason you’re taking Latuda, your doctor will prescribe an appropriate dosage. Your doctor may start you on a low dose of the drug and increase your dose if needed.
The maximum dose of Latuda for children and adolescents is 80 mg.
To learn more about Latuda’s dosage, see this article.
Questions about taking Latuda
Below, we answer some common questions about taking Latuda.
- Can Latuda be chewed, crushed, or cut in half? No, you should not chew, crush, or cut Latuda tablets in half. Instead, you must take the tablets whole. If you have problems swallowing medications, your doctor or pharmacist can provide strategies to help you take Latuda.
- Should I take Latuda with food? Yes, you should take Latuda with food that contains a minimum of 350 calories.
- What if I miss a dose of Latuda? If you miss a dose of Latuda, take the missed dose as soon as you remember. But if it’s close to when your next dose is due, just skip the missed dose. Then, take your next scheduled dose as usual. If you’re unsure about when to take your next dose, ask your doctor or pharmacist.
- Will I need to use Latuda long term? It depends on what you’re using Latuda to treat. For schizophrenia, you’ll likely use the drug long term if Latuda works to manage your symptoms. For depressive episodes related to bipolar 1 disorder, you may use the drug either short term or long term. Your doctor can discuss with you how long you should take Latuda.
- How long does Latuda take to work? How long it takes for Latuda to work may vary from person to person. Talk with your doctor to find out how long Latuda will take before it starts working for your condition.
Do not take more Latuda than your doctor prescribes. Taking more than this can lead to serious side effects.
Symptoms of overdose
Symptoms caused by a Latuda overdose can include:
- irregular heartbeat
- low blood pressure
- decreased alertness
- uncontrollable movement of the muscles in your face, neck, abdomen, pelvis, and throat
What to do in case you take too much Latuda
Call your doctor if you think you’ve taken too much Latuda. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 or your local emergency number. Or go to the nearest emergency room.
Find answers to some commonly asked questions about Latuda.
Will I have withdrawal symptoms if I stop taking Latuda?
No, you won’t have withdrawal symptoms if you stop taking Latuda. (Withdrawal symptoms can occur when you stop taking a drug that your body depends on to function like usual.)
But, newborns who had exposure to an antipsychotic during the last trimester of pregnancy may have withdrawal symptoms. (And keep in mind that Latuda is an antipsychotic.)
Possible withdrawal symptoms that a newborn may have include:
- increased or decreased muscle tone
- breathing problems
- trouble feeding
Be sure to talk with your doctor before taking this drug while pregnant. And for more information about using Latuda during pregnancy, see the “What should be considered before taking Latuda?” section below.
Is Latuda used to treat anxiety or bipolar 2 disorder?
Latuda isn’t approved to treat anxiety or bipolar 2 disorder. But it may be prescribed off-label for treating these or other conditions. With off-label use, doctors prescribe a drug for a purpose other than what it’s approved for.
Instead, Latuda is approved to treat:
With bipolar 1 disorder, you have at least one manic episode, and you may or may not have depressive episodes as well. During manic episodes, you may have increased activity and feel very happy or excited. With bipolar 2 disorder, on the other hand, you have at least one hypomania episode and one depressive episode. A hypomania episode is a mania episode that’s shorter in length and less intense.
If you have questions about whether Latuda is right for your condition, talk with your doctor.
How does Latuda work?
It’s thought that the medication works on serotonin and dopamine receptors (attachment sites) in your brain. The brain chemicals serotonin and dopamine may be involved in schizophrenia and bipolar 1 disorder.
Your doctor or pharmacist can provide more information about how Latuda works.
Latuda is a prescription drug that’s used to treat:
- schizophrenia in adults and adolescents ages 13 years and older
- depressive episodes of bipolar 1 disorder in adults and children ages 10 years and older
- depressive episodes of bipolar 1 disorder in adults who are also taking either:
- lithium (Lithobid), or
- valproate, valproic acid, or divalproex (Depakote)
With schizophrenia, which is a long-term mental health condition, you may have:
- delusions (strongly believing something that’s false)
- disturbances in your thoughts, perceptions, and behaviors
With bipolar 1 disorder, you have at least one manic episode. You may or may not experience depressive episodes as well. During manic episodes, you may feel excessively happy and excited. And you may have symptoms of psychosis. This is unlike depressive episodes, during which you can feel sad or depressed.
Depending on your condition, your doctor may prescribe Latuda alone or with certain other medications.
Below is important information you should consider before taking Latuda.
Taking a drug with certain medications, vaccines, foods, and other things can affect how the drug works. These effects are called interactions.
Before taking Latuda, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also, tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
For more information about Latuda and interactions, see this in-depth article.
Below is a list of medications that can interact with Latuda. This list does not contain all drugs that may interact with Latuda. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
|Drug group or drug name||Drug examples|
|certain antibiotics||• clarithromycin|
• erythromycin (Eryc, Ery-tab)
|certain antifungals||• ketoconazole|
• voriconazole (Vfend)
|certain heart drugs||• diltiazem (Cardizem, others)|
• verapamil (Verelan)
|certain HIV drugs||• ritonavir (Norvir) and drugs that contain it as an ingredient, including Kaletra (lopinavir/ritonavir)|
• efavirenz and drugs that contain it as an ingredient, including Atripla (efavirenz/emtricitabine/tenofovir disoproxil fumarate)
|certain seizure drugs||• phenytoin (Dilantin)|
• carbamazepine (Tegretol, others)
Latuda can also interact with other substances, such as:
- Foods: Grapefruit can interact with Latuda. You should avoid eating grapefruit or drinking grapefruit juice while taking this drug. Talk with your doctor or pharmacist to learn more about this interaction.
- Herbs: The herb St. John’s wort can interact with Latuda. You should avoid taking St. John’s wort while taking Latuda. For more information, talk with your doctor or pharmacist.
- Alcohol: Alcohol is not known to interact with Latuda. However, alcohol may worsen some side effects of Latuda, including sleepiness. Before starting Latuda, ask your doctor or pharmacist whether it’s safe for you to drink alcohol.
Pregnancy and breastfeeding
It’s not known whether Latuda is safe to take during pregnancy.
The effects of Latuda in pregnancy haven’t been studied. But studies of other antipsychotic drugs have been done. They suggest that Latuda may cause withdrawal symptoms in newborns if they had exposure to Latuda as a fetus during the third trimester of pregnancy. Withdrawal symptoms can occur when the body stops receiving a drug it depends on to function like usual.
Possible withdrawal symptoms that may occur in newborns include:
- increase or decrease in muscle tone
- breathing difficulty
- trouble with feeding
If you use Latuda during pregnancy, consider enrolling in Latuda’s pregnancy registry. Pregnancy registries collect information about the risks and effects of a drug during pregnancy. To enroll in the registry and report side effects of Latuda during pregnancy, call 866-961-2388. Or visit the registry’s site. And be sure to talk with your doctor about the risks and benefits of using Latuda during pregnancy.
It’s also not known whether Latuda passes into breast milk or if it affects how your body makes breast milk. The effect on children who are breastfed by people taking Latuda is also unknown. If you’re breastfeeding, your doctor will weigh the benefits and risks of having you take Latuda.
Increased risk of death in older adults with dementia-related psychosis. Older adults with psychosis related to dementia who are taking antipsychotics have an increased risk of dying. (With psychosis, you have an impaired idea of reality. And with dementia, you have loss of memory or other brain functions.)
Keep in mind that Latuda is an antipsychotic, but it isn’t prescribed to treat dementia-related psychosis.
Suicidal thoughts and behaviors in children, adolescents, and young adults. Studies show that antidepressants may increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults (ages 24 years or younger). Keep in mind that Latuda is prescribed for depressive episodes in people with bipolar 1 disorder.
The risk of suicidal thoughts and behaviors is believed to be highest during the first few months of antidepressant treatment and whenever your doctor changes your dosage. But these side effects may occur at any time during treatment.
Some people may have a higher risk of suicidal thoughts or behaviors. For example, people with an increased risk include those who’ve had or whose family members have had:
Tell your doctor immediately if you have any of these symptoms:
- thoughts about suicide or dying
- attempts to die by suicide
- new or worsened depression, anxiety, or irritability
- trouble sleeping
- panic attacks
- an extreme increase in activity or talking, which are both symptoms of mania
Latuda can sometimes cause harmful effects in people who have certain conditions. This is known as a drug-condition interaction. Other factors may also affect whether Latuda is a good treatment option for you.
Talk with your doctor about your health history before you take Latuda. Be sure to tell them if any of the following factors apply to you:
- heart problems, such as heart failure or high blood pressure
- high blood levels of cholesterol or triglycerides (type of fat)
- increased level of a hormone called prolactin
- kidney problems, such as chronic kidney disease
- liver problems, such as liver cirrhosis (severe scarring of the liver)
- low white blood cell counts
- orthostatic hypotension (low blood pressure when getting up from a seated or lying down position)
- stroke in the past
- tardive dyskinesia (uncontrollable body movements)
- past allergic reaction to Latuda
Regardless of whether you have health insurance, cost may be a factor when you’re considering Latuda. What you’ll pay for Latuda may depend on several things, such as your treatment plan and the pharmacy you use.
Here are a few things to consider regarding cost:
- Cost information and savings coupons: You can visit Optum Perks* to get price estimates of what you’d pay for Latuda when using coupons from the site.
- Generic form: Latuda is available as the generic drug lurasidone. Generics usually cost less than brand-name drugs. Talk with your doctor if you’d like to know whether generic lurasidone could be an option for you.
- Savings program: If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. The Latuda Copay Savings Card may also be an option.
* Optum Perks is a sister site of Healthline. Optum Perks coupons cannot be used with any insurance copays or benefits.
Other drugs are available that can treat your condition. If you’d like to explore an alternative to Latuda, talk with your doctor. They can tell you about other medications that might work well for you.
The following drugs are similar to Latuda:
If you have questions about taking Latuda, talk with your doctor or pharmacist. Questions you may want to ask include:
- Is it OK to consume caffeine while I’m taking Latuda?
- Can I drive while taking Latuda?
- Will Latuda make me feel high?
- How long will Latuda stay in my system?
- Can I take both Latuda and lamotrigine (Lamictal)?
To learn more about Latuda, see these articles:
- All About Latuda’s Dosage
- Latuda and Cost: What You Need to Know
- Latuda Interactions: Alcohol, Medications, and Others
- Latuda vs. Abilify: What You Should Know
- Side Effects of Latuda: What You Need to Know
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.