Kalbitor (ecallantide) is a prescription drug used to treat severe swelling caused by hereditary angioedema (HAE). It’s given as an injection under the skin by a healthcare professional, usually as a one-time dose.

Kalbitor is used in adults and certain children to treat sudden symptoms of HAE. This rare genetic condition can cause severe swelling in areas such as your hands, face, and feet. It can also cause swelling of the gastrointestinal tract or airways which can be life threatening.

Kalbitor comes as a liquid solution that’s given as an injection under your skin by a healthcare professional. The active ingredient in Kalbitor is ecallantide. (An active ingredient is what makes a drug work.) Kalbitor belongs to a group of drugs called plasma kallikrein inhibitors.

This article describes the dosage of Kalbitor, as well as its strength and how it’s given. To learn more about Kalbitor, see this in-depth article.

This section describes the usual dosage of Kalbitor.

What is Kalbitor’s form?

Kalbitor comes as a liquid solution that’s given as an injection under your skin.

What strength does Kalbitor come in?

Kalbitor comes in one strength of 10 milligrams (mg) per milliliter (mL) of solution in single-use vials.

What are the usual dosages of Kalbitor?

Your doctor will give you the recommended dosage to treat your condition. They’ll ultimately prescribe the smallest dosage that provides the desired effect. The information below describes dosages that are commonly used or recommended. Your doctor will determine the best dosage to fit your needs.

Dosage for hereditary angioedema

The typical Kalbitor dosage for adults with HAE is 30 mg. A healthcare professional will give you three 10-mg injections under your skin. If you continue to have symptoms of HAE, you may receive another 30-mg dose within 24 hours of the first 30-mg dose.

Because Kalbitor may cause a serious allergic reaction called anaphylaxis, you’ll be monitored closely after you receive your injection. You’ll only receive Kalbitor in a clinic or hospital, given by a trained healthcare professional who recognizes signs of HAE and anaphylaxis and can treat them.

What’s the dosage of Kalbitor for children?

Kalbitor is used to help treat HAE in children ages 12 years and older. The dosage for children is the same as the dosage for adults. (To learn more, see the section directly above.)

For more information about Kalbitor’s dosage for children, talk with your child’s doctor or a pharmacist.

Is Kalbitor used long term?

No. Kalbitor is only used for immediate attacks of HAE. It’s not used long term. If you have questions about your condition and Kalbitor use, talk with your doctor.

Kalbitor comes as a liquid solution that’s given as an injection under your skin. You’ll receive these injections at a clinic or hospital from a trained healthcare professional. They will know the signs of HAE and anaphylaxis and can treat both.

Below are answers to some commonly asked questions about Kalbitor’s dosage.

Is Kalbitor’s dosage similar to that of Takhzyro?

No. While Kalbitor (ecallantide) and Takhzyro (lanadelumab-flyo*) are both given as injections under the skin, their uses differ.

Kalbitor is used to treat an immediate HAE attack. It’s only administered in a hospital or clinic by a healthcare professional. Takhzyro is used to help prevent HAE attacks. Your doctor will show you or a caregiver how to inject the drug at home.

The dose in milligrams for each drug differs. Your doctor will prescribe the drug and the dosage that’s right for you. Talk with them to learn more about how these two drugs compare.

* Takhzyro is a biologic drug (which means it’s made from living cells). The reason “-flyo” appears at the end of the drug’s name is to show that it’s distinct from similar medications that may be created in the future.

How long does it take for Kalbitor to start working?

Kalbitor starts to work after your first dose. But in some cases, you may need a second dose within 24 hours if your HAE symptoms do not improve with the first dose.

Your doctor will monitor you closely during your treatment to be sure the drug is working and to watch for any signs of anaphylaxis.

If you have other questions about what to expect from your Kalbitor treatment, talk with your doctor.

The sections above describe the usual dosage provided by Kalbitor’s manufacturer. If your doctor recommends this drug, they’ll prescribe the dosage that’s right for you. Talk with them if you have questions or concerns about your dosage. Examples of questions you may want to ask include:

  • Will I need more than two doses of Kalbitor if my symptoms don’t improve?
  • Does my risk of anaphylaxis increase if I receive two doses of Kalbitor?
  • How does the dosage of Kalbitor compare with that of Haegarda?

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.