Jesduvroq (daprodustat) is a prescription drug that’s used to treat anemia caused by long-term kidney disease. This drug can interact with alcohol and some other medications. For example, Jesduvroq can interact with clopidogrel.
Jesduvroq is prescribed to adults to treat anemia (low red blood cell count) caused by chronic kidney disease. It’s prescribed to adults who’ve been receiving dialysis for at least 4 months.
Jesduvroq comes as a tablet that you swallow.
An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.
Keep reading to learn about Jesduvroq’s possible interactions. And for more information about Jesduvroq, including details about its uses, see this article.
What to do if you think you’re having a heart attack or strokeIf you think you’re having a heart attack or stroke:
- Call 911 or your local emergency number
- Do not drive yourself to the hospital. You may lose consciousness (pass out).
- Wait for the paramedics to arrive. They can begin lifesaving treatment.
If you think you’re having a heart attack, ask the emergency dispatcher if you should chew an aspirin. This may help break up a blood clot that’s blocking blood flow to the heart muscle. If your doctor has prescribed nitroglycerin for heart-related chest pain, then take a nitroglycerin tablet.
If you think you’re having a stroke, try to remember the time that symptoms began. Tell the emergency dispatcher or paramedics. A clot-busting drug can be given within the first few hours. Try to stay calm and rest until help arrives.
For either a heart attack or stroke, ask that someone stay nearby while you wait for the paramedics. If you lose consciousness (pass out), CPR may be necessary.
Before you start taking Jesduvroq, tell your doctor and pharmacist about any prescription, over-the-counter (OTC), or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Jesduvroq interacts with supplements, herbs, and vitamins, see the “Are there other interactions with Jesduvroq?” section below.)
If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.
The table below lists drugs that may interact with Jesduvroq. Keep in mind that this table does not include all drugs that may interact with Jesduvroq. For more information about some of these interactions, see the “Drug interactions explained” section below.
| Drug group or drug name | Drug examples | What can happen |
| drugs that speed up the CYP2C8 enzyme* | • rifampin (Rifadin, Rimactane) | can make Jesduvroq less effective |
| drugs that slow down the CYP2C8 enzyme* | • gemfibrozil (Lopid) • clopidogrel (Plavix) • deferasirox (Exjade, Jadenu) • teriflunomide (Aubagio) | can increase the risk of side effects from Jesduvroq |
| nonsteroidal anti-inflammatory drugs (NSAIDs) | • aspirin • ibuprofen (Advil, Motrin) • naproxen (Aleve, Naprosyn) | can increase the risk of sores, ulcers, or bleeding in your digestive system |
* CYP2C8 stands for cytochrome P450 2C8. It’s a liver enzyme (a type of protein) that helps to break down Jesduvroq. When other drugs slow down or speed up this enzyme, it affects the amount of Jesduvroq in your body.
Certain health conditions or other factors could raise your risk of harm if you take Jesduvroq. In such cases, your doctor may not prescribe Jesduvroq for you. These are known as contraindications. The list below includes contraindications of Jesduvroq.
If you’ve recently had a heart attack or stroke. Your doctor likely won’t prescribe Jesduvroq if you’ve had a heart attack or stroke in the past 3 months. This is because taking the drug could raise your risk of having another heart attack or stroke. Jesduvroq has a boxed warning about this risk. See “Boxed warning” above to learn more.
If you have high blood pressure that‘s not well managed. If you have high blood pressure that’s not well managed, your doctor likely won’t prescribe Jesduvroq. This is because taking Jesduvroq could cause your blood pressure to get dangerously high.
If you take drugs that are strong CYP2C8 inhibitors. CYP2C8 stands for cytochrome P450 2C8. It’s a liver enzyme (a type of protein) that helps to break down Jesduvroq. Drugs that are strong CYP2C8 inhibitors stop this enzyme from working well. If the enzyme isn’t able to break down Jesduvroq, the drug can build up in your body. This raises your risk of side effects from Jesduvroq. If you take a drug that’s a strong CYP2C8 inhibitor, your doctor likely won’t prescribe Jesduvroq. An example of one of these drugs is gemfibrozil (Lopid).
If you’ve had an allergic reaction. If you have had an allergic reaction to Jesduvroq or any of its ingredients, your doctor likely won’t prescribe Jesduvroq. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.
Before you start taking Jesduvroq, talk with your doctor if any of the factors above apply to you. Your doctor can determine whether Jesduvroq is safe for you to take.
Jesduvroq isn’t known to interact with alcohol. However, both Jesduvroq and alcohol can damage the lining of your stomach. This damage can thin the lining of your stomach and increase the risk of bleeds. Drinking alcohol while taking Jesduvroq can increase this risk even more. Your doctor will most likely recommend that you avoid consuming alcohol during treatment with Jesduvroq.
If you have questions about consuming alcohol while taking Jesduvroq, talk with your doctor or pharmacist.
Learn more about certain drug interactions that can occur with Jesduvroq.
Interaction with drugs that speed up the CYP2C8 enzyme
Jesduvroq can interact with certain drugs that speed up a liver enzyme called cytochrome P450 2C8 (CYP2C8). This enzyme helps to break down Jesduvroq.
An example of a medication that speeds up the CYP2C8 enzyme is the antibiotic rifampin (Rifadin, Rimactane).
What could happen
Taking Jesduvroq with drugs that speed up the CYP2C8 enzyme can increase the breakdown of Jesduvroq. This can make Jesduvroq less effective.
What you can do
If you take Jesduvroq with a medication that speeds up the CYP2C8 enzyme, your doctor may prescribe a dosage of Jesduvroq that’s higher than usual.
If you have questions about taking Jesduvroq with one of these medications, talk with your doctor or pharmacist.
Interaction with drugs that slow down the CYP2C8 enzyme
Jesduvroq can interact with drugs that slow down the CYP2C8 enzyme. This enzyme helps clear Jesduvroq from your body.
Examples of medications that slow down the CYP2C8 enzyme are:
- the cholesterol-lowering drug gemfibrozil (Lopid)
- the blood thinner clopidogrel (Plavix)
- a treatment for iron overload called deferasirox (Exjade, Jadenu)
- the multiple sclerosis treatment teriflunomide (Aubagio)
What could happen
Taking Jesduvroq with drugs that slow down the CYP2C8 enzyme can make Jesduvroq build up in your body. This can raise your risk of Jesduvroq side effects.
What you can do
If you take a medication that significantly slows down the CYP2C8 enzyme, such as gemfibrozil, your doctor will likely not prescribe Jesduvroq.
If you take Jesduvroq with a medication that moderately slows down the CYP2C8 enzyme, such as clopidogrel, your doctor may prescribe a dosage of Jesduvroq that’s lower than usual.
If you have questions about taking Jesduvroq with drugs that slow down the CYP2C8 enzyme, talk with your doctor or pharmacist.
Interaction with nonsteroidal anti-inflammatory drugs (NSAIDs)
It may not be safe to take Jesduvroq with NSAIDs.
NSAIDs are pain relievers that also reduce inflammation (swelling). They include drugs such as:
- aspirin
- ibuprofen (Advil, Motrin)
- naproxen (Aleve, Naprosyn)
What could happen
Jesduvroq and NSAIDs can both cause sores, ulcers, or bleeding in your esophagus, stomach, or intestines. So taking these drugs together can raise your risk of this side effect.
If you’ve had past sores, ulcers, or bleeding in your digestive system, you may have a higher risk of this side effect if you take Jesduvroq with an NSAID.
What you can do
You should avoid taking Jesduvroq with an NSAID unless your doctor recommends it. Keep in mind that many OTC medications contain NSAIDs such as aspirin and ibuprofen. Check with your doctor before taking these medications with Jesduvroq.
If you take Jesduvroq and an NSAID together, see your doctor right away if you have any signs of ulcers or bleeding in your digestive system. These may include indigestion, heartburn, belly pain, trouble swallowing, blood in your vomit, and black, tar-like stools.
If you have questions about taking Jesduvroq with an NSAID, talk with your doctor or pharmacist.
Jesduvroq may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Jesduvroq.
Does Jesduvroq interact with supplements?
Before you start taking Jesduvroq, talk with your doctor and pharmacist about any supplements, herbs, and vitamins you take. Sharing this information with them may help you avoid possible interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Jesduvroq and herbs
There are currently no reports of Jesduvroq interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.
For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Jesduvroq.
Jesduvroq and vitamins
There are currently no reports of Jesduvroq interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.
For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Jesduvroq.
Does Jesduvroq interact with food?
There are currently no reports of Jesduvroq interacting with food. If you have questions about eating certain foods during your treatment with Jesduvroq, talk with your doctor.
Does Jesduvroq interact with vaccines?
There are currently no reports of Jesduvroq interacting with vaccines. If you have questions about getting certain vaccines during your Jesduvroq treatment, talk with your doctor.
Does Jesduvroq interact with lab tests?
There are currently no reports of Jesduvroq interacting with lab tests. If you have questions about having certain lab tests during your treatment with Jesduvroq, talk with the healthcare professional ordering the test.
Does Jesduvroq interact with cannabis or CBD?
There are currently no reports of Jesduvroq interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Jesduvroq.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Certain medical conditions or other health factors may raise the risk of interactions with Jesduvroq. Before taking Jesduvroq, talk with your doctor about your health history. They’ll determine whether Jesduvroq is right for you.
Health conditions or other factors that might interact with Jesduvroq include:
High blood pressure. Jesduvroq can worsen high blood pressure. Your doctor will monitor your blood pressure while you’re taking Jesduvroq. But if you have high blood pressure that’s not well managed, your doctor will likely not prescribe Jesduvroq. For more information, see the “When should I avoid Jesduvroq?” section above.
Heart disease or stroke. If you have heart disease or you’ve had a past heart attack or stroke, you may have a higher risk of blood clots, heart attack, or stroke with Jesduvroq. Jesduvroq has a boxed warning about this risk. See “Boxed warning” above to learn more.
Heart failure. If you have heart failure, taking Jesduvroq could worsen your condition. Talk with your doctor about whether Jesduvroq is right for you.
Cancer. Jesduvroq may increase cancer growth. If you have cancer or have had it in the past, talk with your doctor about whether Jesduvroq is right for you.
Sores in your digestive system. Jesduvroq may cause sores, ulcers, or bleeding in your esophagus, stomach, or intestines. If you’ve had sores, ulcers, or bleeding in your digestive system in the past, you may have a raised risk of experiencing this side effect. Talk with your doctor about whether Jesduvroq is right for you.
Smoking. If you smoke tobacco, you may have an increased risk of developing sores, ulcers, or bleeding in your digestive system with Jesduvroq. Talk with your doctor about whether this medication is right for you.
Liver problems. If you have liver problems, your body may break down Jesduvroq more slowly. This could cause Jesduvroq to build up in your body. And this can raise your risk of side effects. Because of this, your doctor will likely prescribe a dosage of Jesduvroq that’s lower than usual. But if you have severe liver problems, your doctor will likely not prescribe Jesduvroq.
Pregnancy. It’s not known whether Jesduvroq is safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before taking Jesduvroq.
Breastfeeding. It’s not known whether it’s safe to take Jesduvroq while breastfeeding. Due to the possible risk, the drug manufacturer recommends that you not breastfeed your child while taking Jesduvroq and for 1 week after your last dose. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.
Allergic reaction. If you’ve had an allergic reaction to Jesduvroq or any of its ingredients, your doctor will likely not prescribe Jesduvroq. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.
Taking certain steps can help you avoid interactions with Jesduvroq. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:
- Whether you drink alcohol, smoke tobacco, or use cannabis.
- Other medications you take, as well as any vitamins, supplements, and herbs. Your doctor or pharmacist can help you fill out a
medication list . - What to do if you start taking a new drug during your Jesduvroq treatment.
It’s also important to understand Jesduvroq’s
If you have trouble reading or understanding this information, your doctor or pharmacist can help.
Taking Jesduvroq exactly as prescribed can also help prevent interactions.
If you still have questions about Jesduvroq and its possible interactions, talk with your doctor.
Questions you may want to ask your doctor include:
- Do any of my other medications interact with Jesduvroq?
- Does my risk of interactions depend on my dosage of Jesduvroq?
- If I smoke tobacco and take Jesduvroq, does my risk of side effects depend on how much I smoke?
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.