Isoniazid is a generic prescription drug that’s used to treat or prevent tuberculosis (TB). Isoniazid’s cost may depend on factors such as your dosage, whether you have health insurance, and the pharmacy you use.

The price you pay for isoniazid can vary. Your cost may depend on your treatment plan, your insurance coverage, and the pharmacy you use.If you’re prescribed the injection form of isoniazid, your cost may also depend on how much you have to pay to receive the medication by a healthcare professional in a clinic or hospital.

To find out how much you’ll pay for isoniazid, talk with your doctor, pharmacist, or insurance provider. Or look below in the next section to learn how much you can save by using an Optum Perks coupon.

To save money on your isoniazid prescription, explore these Optum Perks coupons.

Save on isoniazid with Optum Perks

Save up to 80% without using insurance.

Enter your information:




300mg Isoniazid (30 Tablets)


Save on isoniazid

Simply show the Optum Perks coupon at your preferred pharmacy and instantly save without using insurance. The coupon doesn't expire so be sure to save it for use with refills.

best price





retail $9



Target (CVS)


retail $9



CVS Pharmacy


retail $9

Retail price refers to the manufacturer’s published list price and is updated as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

Optum Perks and Healthline are subsidiaries of RVO Health.



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Isoniazid only comes as a generic drug. It’s not currently available in a brand-name version. A generic drug contains an exact copy of the active drug in a brand-name medication but tends to cost less. Isoniazid was based on the brand-name drug INH, which is no longer available.

Why is there such a cost difference between brand-name drugs and generics?

Years of research and testing are needed to ensure that brand-name drugs are safe and effective. This testing can make the drugs expensive. The manufacturer of a brand-name drug can sell the drug exclusively for up to 20 years. After that, other drugmakers can create generic versions. This competition in the market can lead to lower costs for generics. And because generics have the same active ingredients as brand-name drugs, they don’t need to be studied again. This can also lead to lower generic costs.

If you take the oral tablet or oral solution form of isoniazid long term, you may be able to lower your costs in the following ways:

Look into getting a 90-day supply of isoniazid. You may be able to get a 90-day supply of oral tablets or oral solution if approved by your insurance company. This could reduce your number of trips to the pharmacy and help lower the cost of isoniazid. If you’re interested in getting a 90-day supply of this drug, talk with your doctor, pharmacist, or insurance provider.

Use a mail-order pharmacy to get your medication. Using a mail-order pharmacy might help lower your cost for isoniazid. Plus, you could get your medication without leaving home. Some Medicare plans may help cover the cost of mail-order drugs. You may also be able to get a 90-day supply of the drug through mail order. If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.

If you need help covering the cost of isoniazid or understanding your insurance, check out these resources:

On these sites, you can find insurance information, details on drug assistance programs, and links to savings cards and other services.

If you have questions about how to pay for your prescription, talk with your doctor or pharmacist.

Below are answers to some frequently asked questions about isoniazid and cost.

How does isoniazid’s cost compare with that of similar drugs, such as rifampin, ethambutol, and pyrazinamide?

The cost of isoniazid compared with the cost of rifampin, ethambutol, and pyrazinamide depends on various factors.

For example, your cost for each drug may depend on whether you have health insurance or if you’re paying out of pocket for the medication. It may also depend on whether you’re prescribed the injection form, which you’ll receive in a hospital or clinic, or an oral form that you’ll take at home.

Other factors that may affect how much you pay include:

  • whether there are any coupon cost savings programs available for the drug you’re prescribed
  • the dosage of the medication you’re prescribed
  • how long your treatment lasts
  • the pharmacy you use (if prescribed an oral form of the drug)

If you have questions about the cost of isoniazid compared with the cost of similar medications, talk with your doctor, pharmacist, or insurance provider. They can share more details on treatment costs based on your specific situation.

How much does isoniazid cost without insurance?

The cost of isoniazid without insurance depends on several factors. But in general, your cost will be higher without insurance.

Your cost for isoniazid may depend on factors such as:

  • your dosage and the form of isoniazid you’re prescribed
  • whether you qualify for any savings programs
  • the pharmacy you choose (if prescribed an oral form of the drug)
  • if you take an oral form, the supply of isoniazid you receive (such as a 30-day or 90-day supply)

If you’re prescribed the injection form of isoniazid, you may have additional costs to receive the medication by a healthcare professional in a hospital or clinic.

To find out the exact cost of isoniazid without insurance, ask your doctor or pharmacist. Also, you may want to check with a few pharmacies to compare prices.

You can also visit Optum Perks* to get price estimates for isoniazid when you use coupons from the site. It’s important to note that Optum Perks coupons cannot be used with insurance copays or benefits.

* Optum Perks is a sister site of Healthline.

If you have insurance, you may need to get prior authorization before your insurance provider will cover isoniazid. This means your insurer and your doctor will discuss isoniazid in regard to your treatment. Then the insurance company will determine whether the drug is covered. If isoniazid requires prior authorization and you don’t receive it before you start treatment, you could pay the full cost of the drug.

Be sure to ask your insurance company whether isoniazid requires prior authorization.

If you still have questions about the cost of isoniazid, talk with your doctor or pharmacist. They may be able to give you a better idea of what you’ll pay for this drug. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you’d pay for isoniazid.

Examples of questions you may want to ask your doctor or insurance provider include:

  • Does the oral solution form of isoniazid cost less than the oral tablets?
  • Will my cost of isoniazid vary based on how long my treatment lasts?
  • If I can’t afford isoniazid, are there other medications to treat my condition that are less expensive?

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.