Fycompa (perampanel) is a prescription drug that’s used to treat certain seizures. The drug comes as a tablet and a liquid suspension, and you swallow either one. You usually take Fycompa once per day.
Fycompa is used in adults and certain children to help treat:
- partial-onset seizure, which is sometimes called focal onset seizure or partial seizure
- primary generalized tonic-clonic seizure, to be taken along with other treatments
The active ingredient in Fycompa is perampanel. An active ingredient is what makes a drug work.
Fycompa belongs to a group of drugs called AMPA glutamate receptor blockers.
Fycompa comes in two forms: an oral tablet and an oral suspension.
This article describes the dosages of Fycompa, as well as its strengths and how to take it. To learn more about Fycompa, see this in-depth article.
The table below highlights the basics of Fycompa’s dosage. All doses are listed in milligrams (mg). A maintenance dosage is what you’ll take throughout treatment, usually after a starting or initial dosage.
|Maintenance dosage for partial-onset seizure
|Maintenance dosage for primary generalized tonic-clonic seizure
|2 mg once daily at bedtime
|increase dose by 2 mg weekly until desired dose is reached
|8–12 mg once daily at bedtime
|8 mg once daily at bedtime
Keep reading for more details about Fycompa’s dosage.
What are Fycompa’s forms?
Fycompa comes in two forms: an oral tablet and an oral suspension. A suspension is a type of liquid mixture.
What strengths does Fycompa come in?
Fycompa oral tablets come in several strengths:
- 2 milligrams (mg)
- 4 mg
- 6 mg
- 8 mg
- 10 mg
- 12 mg
Fycompa oral suspension comes in one strength of 0.5 mg per milliliter (mg/mL).
What are the usual dosages of Fycompa in adults?
Your doctor will likely start you on a low dosage and adjust it over time to reach the right amount for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.
The information below describes dosages that are commonly taken or recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.
Dosage for seizure
Your doctor may start you on a low dosage at the start of treatment. The initial dosage for both approved uses is 2 mg once daily at bedtime. Your doctor may increase your dose by 2 mg every week until you reach your desired dose.
The typical Fycompa maintenance dosage for adults with partial-onset seizure is 8–12 mg once daily at bedtime. The maintenance dosage for adults with primary generalized tonic-clonic seizure is 8 mg once daily at bedtime.
What’s the dosage of Fycompa for children?
Doctors prescribe Fycompa to help treat partial-onset seizure in children ages 4 years and above. Doctors also prescribe Fycompa to help treat primary generalized tonic-clonic seizure in children ages 12 years and above.
The dosage taken by children is the same as the dosage taken by adults. To learn more, see the “What are the usual dosages of Fycompa in adults?” section above.
For more information about Fycompa’s dosage for children, talk with your child’s doctor or a pharmacist.
Is Fycompa taken long term?
Yes, Fycompa is usually taken as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.
Certain antiepileptic medications interfere with Fycompa. Examples include phenytoin, carbamazepine, and oxcarbazepine, but there may be others. If you take any of these, your doctor may need to increase your initial dosage of Fycompa. When starting or stopping these antiepileptic medications, your doctor may need to adjust your Fycompa dosage.
If you have liver problems, your doctor may need to adjust your dosage of Fycompa. The maximum dosage a person with liver problems can take is lower than usual. The dosage adjustment depends on the severity of liver problems. If your liver problems are severe, Fycompa may not be right for you.
People with kidney problems also may need dosage adjustments. Depending on the severity of your kidney problems, Fycompa may not be right for you.
Older adults ages 65 years and above may need adjustments during dosage increases.
The dosage of Fycompa your doctor prescribes may depend on several factors. These include:
- the type and severity of the condition the drug is treating
- your age
- other conditions you may have (see the “Dosage adjustments” section above)
Fycompa is available as an oral tablet. If you have difficulty swallowing tablets, see this article for tips on how to take this form of medication.
Fycompa is also available as an oral suspension, which is a type of liquid mixture. Before measuring your dose, shake the bottle well. Be sure to use the adapter and measuring device included with your prescription. The measuring device has markings that help you measure your dosage accurately.
For information on the expiration, storage, and disposal of Fycompa, talk with your doctor or pharmacist.
Accessible drug containers and labels
Some pharmacies provide medication labels that:
- have large print
- use braille
- feature a code you can scan with a smartphone to change the text to audio
Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.
Let your pharmacist know if you have difficulty opening medication bottles. They may have tips to help, or they may be able to supply Fycompa in an easy-open container.
If you miss a dose of Fycompa, skip the missed dose. Then take your next dose the following day at the usual scheduled time. If you miss more than one day of medication, talk with your doctor or pharmacist about what to do.
If you need help remembering to take your dose of Fycompa on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.
Do not take more Fycompa than your doctor prescribes, as this can lead to harmful effects.
Symptoms of overdose
Symptoms caused by an overdose can include:
- change in consciousness
- change in behavior or emotional state
- change in mental status, such as disorientation
- problems with balance
In extreme cases or if untreated, overdose may lead to coma.
What to do in case you take too much Fycompa
Call your doctor right away if you think you’ve taken too much Fycompa. You can also call 800-222-1222 to reach America’s Poison Centers, or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.
Taking Fycompa can lead to physical dependence. This condition occurs when your body relies on a drug to function as usual.
If you suddenly stop taking Fycompa, you may experience withdrawal symptoms. These side effects can occur when you stop taking a drug on which your body has become dependent.
Examples of withdrawal symptoms include:
- feeling nervous, anxious, or irritable
- low energy
- weakness or no enthusiasm
- sudden changes in mood
- trouble sleeping
- diarrhea and vomiting
- watery eyes
- runny nose
- abdominal pain
- feeling colder or hotter than usual
Before you end your Fycompa treatment, your doctor may lower your dosage slowly over time. This can help reduce your risk of withdrawal symptoms after you stop treatment.
If you have withdrawal symptoms after you’ve stopped taking Fycompa, talk with your doctor. They can recommend ways to ease these symptoms.
Below are answers to some commonly asked questions about Fycompa’s dosage.
What is the recommended maximum daily dose of Fycompa?
The recommended maximum daily dose of Fycompa is 12 milligrams (mg) for most people.
The maximum daily dose of Fycompa may differ for people who have liver problems. For people with mild liver problems, the maximum daily dose is 6 mg. For people with moderate liver problems, the maximum daily dose is 4 mg.
People taking certain antiepileptic drugs may need higher doses of Fycompa. Examples include phenytoin, carbamazepine, and oxcarbazepine, but there may be others. For people taking specific antiepileptic drugs, the maximum daily dose of Fycompa has not been set by the drug manufacturer. In studies, the highest daily dose of Fycompa for people on these antiepileptic drugs was 12 mg.
Talk with your doctor if you have questions about your maximum daily dose.
How long does it take for Fycompa to start working?
Fycompa starts to work after your first dose. Because of how the drug works, you likely won’t feel the drug working in your body. But your doctor will monitor you during treatment to check whether the drug is working for your condition.
In studies, people had significant decreases in seizures over 28 days.
If you have other questions about what to expect from your Fycompa treatment, talk with your doctor.
The sections above describe the usual dosages provided by the manufacturer. If your doctor recommends Fycompa for you, they’ll prescribe the dosage that’s right for you.
Remember, you should not change your dosage of Fycompa without your doctor’s recommendation. Only take Fycompa exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.
Here are some examples of questions you may want to ask your doctor:
- How will my dosage change if I switch from Fycompa’s oral tablets to oral suspension?
- How will I know which daily dosage of Fycompa is right for me?
- If I need to take the maximum recommended dosage of Fycompa, does my risk of side effects increase?
To learn more about Fycompa, see the “Fycompa (perampanel)” overview article.
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.