Exondys 51 (eteplirsen) is a prescription drug used to treat Duchenne muscular dystrophy. The drug comes as a liquid solution. It’s usually given once per week.
Exondys 51 is used to treat a specific type of Duchenne muscular dystrophy in adults and children.
The active ingredient in Exondys 51 is eteplirsen. Exondys 51 belongs to a group of drugs called antisense oligonucleotides. These drugs work by helping your body read genetic instructions to make proteins that are usually lacking in Duchenne muscular dystrophy.
This article describes the dosage of Exondys 51, as well as its strength and how it’s given. To learn more about Exondys 51, see this in-depth article.
This section describes the usual dosages of Exondys 51. Keep reading to learn more.
What is Exondys 51’s form?
Exondys 51 is available as a liquid solution that’s given as an intravenous (IV) infusion (an injection into your vein over a period of time).
What strength does Exondys 51 come in?
Exondys 51 comes in one strength: 50 milligrams per milliliter of solution (mg/mL).
What are the usual dosages of Exondys 51 in adults?
The information below describes dosages that are commonly given or recommended. But your doctor will determine the best dosage to fit your needs.
Dosage for Duchenne muscular dystrophy
The typical Exondys 51 dosage for adults with Duchenne muscular dystrophy is based on a person’s body weight. The recommended dosage is 30 mg per kilogram (kg) of body weight, given once weekly. A kilogram equals approximately 2.2 pounds.
What’s the dosage of Exondys 51 for children?
Exondys 51 is used to help treat Duchenne muscular dystrophy in children. It’s important to note that the people enrolled in studies were all male and ranged in age from 6 months to 19 years at the time they entered the study.
As with the dosage for adults, the dosage for children is determined by weight. To learn more, see the “What are the usual dosages of Exondys 51?” section above.
How to receive Exondys 51
Exondys 51 comes as a liquid solution that’s given as an IV infusion by a healthcare professional. The infusion is given once per week and typically lasts about 35 to 60 minutes.
Is Exondys 51 used long term?
Yes, Exondys 51 is usually a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely use it long term.
Below are answers to some commonly asked questions about Exondys 51’s dosage.
Is Exondys 51’s dosage similar to that of Amondys 45?
Yes. Exondys 51 (eteplirsen) and Amondys 45 (casimersen) both come as a liquid solution that’s given once weekly as an IV infusion by a healthcare professional. Both drugs are available in one strength of 50 mg/mL.
To learn more about how these drugs compare, talk with your doctor.
Is Exondys 51’s dosage similar to that of Vyondys 53?
Yes. Exondys 51 (eteplirsen) and Vyondys 53 (golodirsen) both come as a liquid solution that’s given once weekly as an IV infusion by a healthcare professional. Both drugs are available in one strength of 50 mg/mL.
To learn more about how these drugs compare, talk with your doctor.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.