Evenity (romosozumab-aqqg) is a prescription drug used to treat osteoporosis in certain people. Evenity isn’t known to interact with alcohol, other medications, or supplements. But it may not be safe for people with certain medical conditions.

Evenity is used to treat osteoporosis in certain females* who’ve gone through menopause.

Evenity comes as a liquid solution inside prefilled syringes. A healthcare professional will administer Evenity by injecting it under your skin.

An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.

Keep reading to learn about Evenity’s possible interactions. And for more information about the drug, including details about its uses, see this article.

* In this article, we use the term ”female” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.

There are currently no reports of Evenity interacting with other drugs. But this doesn’t mean that interactions won’t be recognized in the future. For example, new drugs may be approved that may interact with this medication.

Before you start Evenity treatment, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Evenity interacts with supplements, herbs, and vitamins, see the “Are there other interactions with Evenity?” section below.)

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

Certain health conditions or other factors could raise your risk of harm if you use Evenity. In such cases, your doctor may not prescribe Evenity for you. These are known as contraindications. The list below includes contraindications of Evenity.

If you have low calcium levels: Evenity can lower the level of calcium in your blood. If you already have a low calcium level, your doctor likely will not prescribe Evenity for you. This is because it could make your calcium level fall dangerously low.

If you have low calcium levels, your doctor may have you take supplements to raise your calcium levels before you start Evenity treatment. In addition, anyone receiving Evenity will need to take calcium and vitamin D supplements throughout their treatment to help prevent low calcium levels.

Past heart attack or stroke: If you’ve had a heart attack or stroke in the past year, your doctor likely will not prescribe Evenity for you. This is because you may have a higher risk of heart attack and stroke with Evenity. In fact, Evenity has a boxed warning about this risk. To learn more, see the “Boxed warning” section at the top of this article.

If you’ve had an allergic reaction: If you have had an allergic reaction to Evenity or any of its ingredients, your doctor likely will not prescribe Evenity for you. This is because receiving the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.

Before starting Evenity treatment, talk with your doctor if any of the factors above apply to you. Your doctor can determine whether Evenity is safe for you.

Evenity is not known to interact with alcohol. But Evenity and alcohol can cause some similar side effects, such as headache. You may be more likely to experience these side effects if you drink alcohol during your Evenity treatment.

It’s important to note that regularly drinking large amounts of alcohol can affect how well your body absorbs calcium. This can lead to low calcium levels. Evenity can also cause low calcium levels.

Consuming large amounts of alcohol over time can also increase your risk for cardiovascular problems, such as heart attack or stroke. And Evenity has a boxed warning about this risk. To learn more, see the “Boxed warning” section at the top of this article.

If you have questions about how much alcohol may be safe to consume during your Evenity treatment, talk with your doctor or pharmacist.

Evenity may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Evenity.

Does Evenity interact with supplements?

Before you start taking Evenity, talk with your doctor and pharmacist about any supplements, herbs, and vitamins you take. Sharing this information with them may help you avoid possible interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Evenity and herbs

There are currently no reports of Evenity interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Evenity.

Evenity and vitamins

There are currently no reports of Evenity interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Evenity.

Does Evenity interact with food?

There are currently no reports of Evenity interacting with food. If you have questions about eating certain foods during your treatment with Evenity, talk with your doctor.

Does Evenity interact with vaccines or lab tests?

There are currently no reports of Evenity interacting with vaccines or lab tests. But that doesn’t mean such interactions won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before receiving any vaccines or having lab tests done during your Evenity treatment.

Does Evenity interact with cannabis or CBD?

There are currently no reports of Evenity interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Evenity.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions or other health factors may raise the risk of interactions with Evenity. Before starting Evenity treatment, talk with your doctor about your health history. They’ll determine whether Evenity is right for you.

Health conditions or other factors that might interact with Evenity include:

Cardiovascular problems or certain risk factors: Evenity can increase your risk of heart attack, stroke, and death due to cardiovascular (heart and blood vessel) problems. Because of this risk, your doctor will likely not prescribe Evenity if you’ve had a heart attack or stroke in the past year or if you have other risk factors for heart attack or stroke. To learn more, see the “Boxed warning” section above.

Low calcium levels: Evenity can lower the level of calcium in your blood. If you already have low calcium levels, your doctor will likely not prescribe Evenity for you until your levels have been increased with calcium supplements. To help prevent low calcium levels during your Evenity treatment, you’ll take calcium and vitamin D supplements. (Vitamin D helps your body absorb calcium.) Your doctor will also order regular blood tests to monitor your calcium levels during your Evenity treatment.

Severe kidney problems: If you have severe kidney problems, you may have a raised risk of low calcium levels with Evenity (see just above). While taking Evenity, be sure to take your calcium and vitamin D supplements as prescribed by your doctor.

Dental problems or upcoming dental treatment: Evenity can cause serious problems with your jawbone. If you have dental problems such as gum disease or tooth infections, you may have a raised risk for this side effect. Having dental treatment such as tooth extractions while taking Evenity can also raise your risk of this side effect. You should have a dental exam and any required dental treatment before starting Evenity treatment. If you need any dental work while taking Evenity, be sure to tell your dentist that you’re taking this medication.

Pregnancy: It’s not known whether Evenity is safe to take during pregnancy. The drug is only used in females* who’ve gone through menopause, which means they’re unable to become pregnant. If you’re pregnant or planning a pregnancy, talk with your doctor about your treatment options.

Breastfeeding: It’s not known whether it’s safe to take Evenity while breastfeeding. The drug is only used in females* who’ve gone through menopause, which means they’re unlikely to be breastfeeding. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your treatment options.

Allergic reaction: If you’ve had an allergic reaction to Evenity or any of its ingredients, your doctor will likely not prescribe Evenity. This is because the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.

* In this article, we use the term ”female” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.

Taking certain steps can help you avoid interactions with Evenity. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:

  • Whether you drink alcohol, smoke, or use cannabis.
  • Other medications, as well as any vitamins, supplements, and herbs, you take. Your doctor or pharmacist can help you fill out a medication list.
  • What to do if you start taking a new drug during your Evenity treatment.

It’s also important to understand Evenity’s label and other paperwork that may come with the drug. Colored stickers that describe interactions may be on the label. And the paperwork (sometimes called the patient package insert or medication guide) may have other details about interactions. (If you did not get paperwork with Evenity, ask your pharmacist to print a copy for you.)

If you have trouble reading or understanding this information, your doctor or pharmacist can help.

If you still have questions about Evenity and its possible interactions, talk with your doctor.

Questions you may want to ask your doctor include:

  • Which calcium and vitamin D supplements will I take with Evenity, and will these interact with my other medications?
  • Should I make any lifestyle changes to lower my risk of heart attack and stroke with Evenity?
  • What oral hygiene regime do you recommend during Evenity treatment?

To learn more about Evenity, see these articles:

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.