Entyvio (vedolizumab) is a prescription drug that’s used to treat Crohn’s disease and ulcerative colitis. Entyvio comes as an injection that’s given under your skin or slowly into your vein.
Entyvio is used in adults to treat the following types of inflammatory bowel disease (IBD):
To learn more about Entyvio’s uses, see the “What is Entyvio used for?” section below.
Entyvio contains the active ingredient vedolizumab. (An active ingredient is what makes a drug work.)
Entyvio is a biologic medication. A biologic is made from parts of living organisms. It’s available only as a brand-name drug. It isn’t available in a biosimilar form.
Biosimilars are like generic drugs. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.
Like most drugs, Entyvio may cause mild or serious side effects. The lists below describe some of the more common side effects. These lists don’t include all possible side effects.
Keep in mind that side effects of Entyvio can vary depending on:
- the form of Entyvio you receive
- your age
- other health conditions you have
- how well your immune system is working
- other medications you may be taking
Your doctor or pharmacist can tell you more about the potential side effects of Entyvio. They can also suggest ways to help reduce side effects.
Mild side effects
Here’s a list of some of the mild side effects Entyvio can cause. To learn about other mild side effects, talk with your doctor or pharmacist, or read Entyvio’s prescribing information.
Mild side effects of Entyvio that have been reported include:
- runny nose
- fatigue (lack of energy)
- upper respiratory infection, such as a cold
- back pain
- influenza (flu)
- skin side effects, such as rash or itchiness
- injection site reaction, such as swelling or bruising, if you’re taking the form of Entyvio that’s injected under your skin
- joint pain*
Mild side effects of many drugs may go away within a few days or a couple of weeks. But if they become bothersome, talk with your doctor or pharmacist.
* For more information about this side effect, see the “Side effect focus” section below.
Serious side effects
Serious side effects from Entyvio can occur, but they aren’t common. If you have serious side effects from Entyvio, call your doctor right away. But if you think you’re having a medical emergency, you should call 911 or your local emergency number.
Serious side effects of Entyvio that have been reported include:
- infusion reaction (a type of allergic reaction that can happen after receiving an infusion of a drug)
- liver problems, such as liver damage
- serious infections, including:
- sepsis (a life threatening response to an infection)
- immunogenicity (an immune response to Entyvio that can cause side effects or worsening of your condition)
- progressive multifocal leukoencephalopathy (PML), which is a serious viral brain infection*
- allergic reaction*
* For more information about this side effect, see the “Side effect focus” section below.
Side effect focus
Learn more about some of the side effects Entyvio may cause. You can also see this article for specifics about Entyvio’s side effects.
Brain infection called progressive multifocal leukoencephalopathy (PML)
The risk of PML is higher if your immune system activity is reduced (sometimes referred to as having a weakened immune system). You may have reduced immune system activity if you have HIV, cancer, or a transplanted organ. This may also happen if you’re taking immunosuppressant drugs.
Symptoms of PML may include:
- vision changes
- trouble with balance
- trouble moving your arms and legs
- drooping of your face
- weakness that steadily gets worse
- problems with your memory and ability to speak
- changes in your personality
What might help
While you’re taking Entyvio, your doctor will monitor you for PML.
If you have PML, your doctor will have you stop treatment with Entyvio. This allows your immune system to recover and fight off the infection. Your doctor may also recommend other treatments for PML.
Before taking Entyvio, talk with your doctor about your risk for PML. Tell them if you have any conditions that reduce the activity of your immune system. Your doctor can tell you more about this side effect.
With liver problems, you may have:
- jaundice (yellowing of your skin or the whites of your eyes)
- nausea or vomiting
- loss of appetite
What might help
Before starting Entyvio, tell your doctor if you’ve ever had hepatitis or other serious liver problems.
If you have symptoms of liver problems with Entyvio, call your doctor right away. They can check your liver function. If needed, they’ll have you stop treatment with Entyvio.
Talk with your doctor about your risk of liver problems with Entyvio.
Entyvio can cause joint pain. It’s important to know that joint pain is common in people with inflammatory bowel disease (IBD), which Entyvio treats.
The most common types of joint pain with IBD affect the ankle, wrist, and knee joints.
What might help
If you have arthritis or joint pain, tell your doctor before taking Entyvio. They can tell you if Entyvio may worsen your joint problem.
Your doctor can also tell you ways to manage joint pain. And they’ll recommend whether the benefits of Entyvio outweigh its risks. There are some tips you can try at home to reduce joint pain.
Some people may have an allergic reaction to Entyvio.
Symptoms of a mild allergic reaction can include:
- skin rash
- flushing (temporary warmth, redness, or deepening of skin color)
A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing.
Call your doctor right away if you have an allergic reaction to Entyvio. But if you think you’re having a medical emergency, call 911 or your local emergency number.
Costs of prescription drugs can vary depending on many factors. These factors include what your insurance plan covers and which pharmacy you use.
If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. You can also visit the Entyvio manufacturer’s website to see their support options. And for more information about Entyvio’s cost, you can see this article.
Find answers below to some commonly asked questions about Entyvio.
How does Entyvio work? Is it an immunosuppressant?
Entyvio belongs to a group of drugs called integrin receptor antagonists. It works by blocking the effects of integrin (a type of protein).
Integrin causes white blood cells responsible for inflammation to enter your digestive tract. It’s thought that people with inflammatory bowel disease (IBD) have an overactive immune system, which causes inflammation. And Entyvio is used to treat IBD.
The exact mechanism of action of Entyvio isn’t known. It’s believed that by blocking integrin, Entyvio reduces inflammation in your digestive tract.
Entyvio isn’t a systemic immunosuppressant. (Systemic drugs affect your whole body.) Entyvio has a selective effect on your gut. It doesn’t affect your entire immune system.
Instead, Entyvio is an immunotherapy medication. This means it works with your immune system to treat your condition.
If you’d like to know more about how Entyvio works for your condition, ask your doctor for details.
Are there any reviews available from people who’ve used Entyvio?
The manufacturer of Entyvio provides some reviews from people who’ve taken this drug. You can find those reviews here. Keep in mind that everyone’s experience with Entyvio treatment can be different.
You can also ask your doctor for more information about their experience with Entyvio and how other people they’ve cared for have responded to the drug. Your doctor can also tell you about studies of people who’ve taken Entyvio.
Does Entyvio cause weight gain? How can you manage or lose weight while using Entyvio?
Weight gain hasn’t been reported as a side effect of Entyvio.
But it’s possible for you to gain some weight if your symptoms lessen or disappear with Entyvio treatment. This may happen when the drug reduces inflammation and pain in your digestive tract.
Will I have hair loss with Entyvio?
If you have hair loss while you’re taking Entyvio, talk with your doctor. They can check to see what’s causing your hair loss. And they may offer solutions to help manage it.
How long do Entyvio’s side effects last? Does it cause long-term side effects?
Your side effects from Entyvio and how long they last will depend on individual factors. These include:
- your overall health
- other medications you may be taking
- your age
In some cases, you may have serious side effects with Entyvio that don’t go away. If this happens, tell your doctor right away. They’ll discuss your options, including whether you’ll need to stop taking Entyvio.
Your doctor will recommend the dosage of Entyvio that’s right for you. For specifics about Entyvio’s dosage, you can also see this article.
Forms and strengths
Entyvio comes as:
- a powder that a healthcare professional mixes with sterile solution and gives as an intravenous (IV) infusion (an injection into a vein that’s given over time)
- a liquid solution that’s given as a subcutaneous injection (an injection under your skin), which is available in:
- a single-dose prefilled syringe
- a single-dose prefilled injection pen
The IV infusion form of Entyvio comes in a strength of 300 milligrams (mg). The solution for subcutaneous injection comes in a strength of 108 mg per 68 milliliters (108 mg/0.68 mL).
Below are commonly used dosages, but the dosage you receive will be determined by your doctor.
Note: There’s no loading dose for Entyvio. (With a loading dose, a drug is given at a higher dose than usual at the start of treatment. This can help you have benefits sooner with treatment.) There is an induction dosage phase at the start of Entyvio treatment, however. This means you’ll get your first several doses more frequently than your later doses.
Dosage for ulcerative colitis
For ulcerative colitis, your treatment will start with Entyvio infusions. After this, your doctor might prescribe Entyvio as an IV infusion or a subcutaneous injection (an injection under your skin).
Infusion dosage schedule
When you begin treatment, you’ll receive one 300-mg dose of Entyvio. Then, you’ll receive another dose 2 weeks later, and another dose 4 weeks later.
After this, you’ll receive the drug once every 8 weeks to maintain remission of your condition. (With remission, you do not have symptoms of the condition.)
For ulcerative colitis treatment, your doctor may switch you to subcutaneous injections after your second Entyvio infusion (see just below).
If your condition doesn’t improve by week 14 of Entyvio treatment, your doctor will likely have you stop the drug.
Subcutaneous dosage schedule
If your doctor prescribes Entyvio subcutaneous injections, you’ll first receive two Entyvio infusions: One to start your treatment, and one 2 weeks later.
Then, you’ll have an Entyvio subcutaneous injection 4 weeks after your second infusion. After this, you’ll have an Entyvio injection every 2 weeks.
Your doctor might switch you to subcutaneous injections if your condition is responding well to Entyvio treatment. If your condition doesn’t improve by week 14 of Entyvio treatment, your doctor will likely have you stop the drug.
Dosage for Crohn’s disease
Entyvio’s recommended infusion schedule for Crohn’s disease is the same as that for ulcerative colitis, described just above under “Infusion dosage schedule.” Entyvio subcutaneous injections are not approved for treating Crohn’s disease.
Questions about Entyvio’s dosing
Below are some common questions about Entyvio’s dosing.
- What if I miss a dose of Entyvio? Entyvio infusions are given at a doctor’s office or clinic. Subcutaneous injections may also be given in your doctor’s office or clinic, or you might be able to inject the drug yourself at home. If you miss an appointment, call your doctor’s office so they can reschedule your appointment as soon as possible. If you’re self-injecting Entyvio and you miss a dose, inject the missed dose as soon as possible. Your next dose should be 2 weeks later. If you aren’t sure whether you injected an entire dose, contact your doctor or local pharmacy, and they can give you instructions.
- Will I need to use Entyvio long term? How long you’ll receive Entyvio depends on how well your condition responds to the drug. It can also depend on whether you have serious side effects from it. The drug is meant to be used long term to manage your symptoms. However, if your condition doesn’t improve by week 14 of Entyvio treatment, your doctor will likely have you stop the drug. Your doctor will carefully monitor you during treatment. They’ll discuss your treatment plan and how long you should take Entyvio.
- How long does Entyvio take to work? Entyvio is given in two phases. During the first, called the induction phase, you’ll get three doses of Entyvio over 6 weeks. During the second, called the maintenance phase, you’ll receive Entyvio once every 8 weeks or once every 2 weeks. In studies, most people had significantly fewer symptoms at week 6 of treatment. You may see some symptom relief after your first dose of Entyvio. But it may take several weeks for you to be free of symptoms. If you don’t have significantly reduced symptoms by week 14 of treatment, your doctor will likely have you stop taking Entyvio.
Entyvio may be given as:
- IV infusions, which are injections given slowly into your vein.
- injections under your skin, which are given using a prefilled injection pen or prefilled syringe. This form of Entyvio is only prescribed for ulcerative colitis treatment.
IV infusions are given by a healthcare professional at a doctor’s office or clinic. Entyvio infusions last 30 minutes. Your doctor will monitor you during and after the infusion time. This way, they can make sure you don’t have an allergic reaction, infusion reaction, or other serious reaction to the drug.
Injections under your skin can be given in your doctor’s office or clinic, or you might be able to inject Entyvio yourself at home. You could also have a caregiver inject it for you, such as a family member.
Your doctor or another healthcare professional will show you how to inject Entyvio. It can be injected into your abdomen or thigh. Caregivers can also inject Entyvio into your upper arm.
You should discard your Entyvio injection pen or syringe after each dose, using an
Questions about taking Entyvio
Here’s a list of common questions related to taking Entyvio.
- Should I take Entyvio with food? It doesn’t matter. Entyvio is not affected by whether you’ve eaten.
- Is there a best time of day to receive Entyvio infusions? There’s no specific time of day that’s best to receive Entyvio. It’s important to get your doses according to the schedule prescribed by your doctor.
Questions for your doctor
You may have questions about Entyvio and your treatment plan. It’s important to discuss all your concerns with your doctor.
Here are a few tips that might help guide your discussion:
- Before your appointment, write down questions such as:
- How will Entyvio affect my body, mood, or lifestyle?
- Bring someone with you to your appointment if doing so will help you feel more comfortable.
- If you don’t understand something related to your condition or treatment, ask your doctor to explain it to you.
Remember, your doctor and other healthcare professionals are available to help you. And they want you to get the best care possible. So don’t be afraid to ask questions or offer feedback on your treatment.
Before you start treatment with Entyvio, ask your doctor about the benefits and risks of treatment. Tell them about all your health conditions and any medications you’re currently taking.
These and other considerations are described below.
Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. These effects are called interactions.
Before taking Entyvio, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types. Also describe any vitamins, herbs, or supplements you use. Your doctor or pharmacist can tell you about any interactions these items may cause with Entyvio.
Interactions with drugs or supplements
Entyvio can interact with several types of drugs. Certain interactions may increase your risk for infections with Entyvio treatment.
Examples of drugs that should not be used with Entyvio include:
- tumor necrosis factor (TNF) inhibitors, which are used for autoimmune diseases, such as:
- natalizumab (Tysabri), which is used for multiple sclerosis and Crohn’s disease
This list does not contain all types of drugs that may interact with Entyvio. Your doctor or pharmacist can tell you more about these interactions and any others that may occur with use of Entyvio.
You should not take any live vaccines while you’re receiving Entyvio. (Live vaccines contain weakened, but live germs they’re meant to protect you from.)
This is because Entyvio lowers your immune system’s ability to fight off infections. Getting a live vaccine while you’re taking Entyvio increases your risk of getting the disease the vaccine should prevent.
Examples of live vaccines include:
- chickenpox (Varivax)
- measles, mumps, rubella (MMR)
- flu vaccine that’s given as a nasal spray (FluMist)
- rotavirus vaccine
- yellow fever vaccine
- smallpox vaccine
Before starting treatment with Entyvio, talk with your doctor about your immunizations. Be sure you’re up to date on vaccinations before starting Entyvio. Also, ask your doctor if it’s safe for people in your home to receive live vaccines while you’re receiving Entyvio.
Entyvio and COVID-19 vaccines
The COVID-19 vaccines that are currently approved for use in the United States aren’t live vaccines. If you haven’t received one, check with your doctor about doing so before starting Entyvio.
Entyvio can increase your risk for some infections. Ask your doctor for more information about the safety of receiving a COVID-19 vaccine while you’re taking Entyvio.
Entyvio may not be right for you if you have certain medical conditions or other factors that affect your health. Talk with your doctor about your health history before you take Entyvio. Factors to consider include those in the list below.
- Infections. If you have an infection, you should not start taking Entyvio until the infection is cleared from your body. And if you develop a serious infection while you’re receiving Entyvio, your doctor will have you stop the drug. Then, they’ll treat the infection before having you start taking Entyvio again.
- Allergic reaction. If you’ve had an allergic reaction to Entyvio or any of its ingredients, you should not take Entyvio. Ask your doctor what other medications are better options for you.
- Infusion reaction. In rare cases, some people have an infusion reaction when receiving infusions of Entyvio. Your doctor will monitor you for infusion reactions when you receive doses of the drug. And they’ll stop the infusion if you have a serious reaction to Entyvio.
- Liver problems. Tell your doctor if you’ve ever had liver disease. Entyvio can make liver problems worse. If needed, your doctor will monitor your liver function while you’re taking Entyvio. Ask your doctor for more information about this.
- Immune system problems. Progressive multifocal leukoencephalopathy (PML) is a rare, serious infection that affects the brain, and a rare but possible side effect of Entyvio. You may have a higher risk of PML if you have HIV, cancer, a transplanted organ, or other health conditions that affect your immune system. Your doctor can discuss whether Entyvio is safe for you to take.
Entyvio and alcohol
There aren’t any known interactions between Entyvio and alcohol.
But drinking alcohol may worsen symptoms of inflammatory bowel disease, which Entyvio is used to treat. It can also increase some of the drug’s side effects, such as nausea and headache.
Drinking large amounts of alcohol while taking Entyvio can also increase your risk for liver damage.
If you drink alcohol, ask your doctor if it’s safe to drink alcohol while you’re taking Entyvio, and if so, how much is safe.
Pregnancy and breastfeeding
It’s not known whether Entyvio treatment is safe during pregnancy or while breastfeeding.
If you’re pregnant or planning to become pregnant, talk with your doctor about using Entyvio. They can provide information about the drug’s risks and benefits.
Also, if you’re pregnant and taking Entyvio, you can sign up for the drug’s pregnancy registry. To do this, call 877-TAKEDA7 (877-825-3327). Pregnancy registries gather information about certain drugs and their effects during pregnancy. This data can help researchers and doctors understand the risks of using a drug during pregnancy.
Entyvio does pass into breast milk. But the risks from Entyvio exposure in children who are breastfed are not clear. Talk with your doctor about the safety of breastfeeding while taking Entyvio. They may offer suggestions on alternative ways to feed your child while you’re receiving Entyvio.
Entyvio and Remicade are both used to manage symptoms of inflammatory bowel disease. Specifically, they’re both used for Crohn’s disease and ulcerative colitis. Remicade is also used to manage other autoimmune conditions.
Remicade has the active ingredient infliximab, and Entyvio has the active ingredient vedolizumab. Both drugs are given by intravenous (IV) infusion, which is an injection that’s given slowly into your vein. Entyvio can also be given as an injection under your skin, for ulcerative colitis treatment.
Talk with your doctor if you have more questions about Entyvio versus Remicade. You can also check out this detailed breakdown of the two medications.
Humira has the active ingredient adalimumab, and Entyvio has the active ingredient vedolizumab.
Humira and Entyvio each come as injections given under your skin. You can give these drugs to yourself at home, in some cases.
Entyvio is also given by intravenous (IV) infusion, which is an injection that’s given slowly into your vein. This is done at your doctor’s office or clinic.
If you’d like to know about the similarities and differences between Entyvio and Humira, see this comparison. And talk with your doctor about which drug is right for you.
Entyvio and Stelara have similarities, but they also have some important differences.
Both Stelara and Entyvio are biologic drugs. Biologics are drugs made from living organisms. These two drugs work by blocking certain proteins that cause inflammation. But they work in different ways.
Stelara has the active ingredient ustekinumab, and Entyvio has the active ingredient vedolizumab.
Entyvio and Stelara are both used in adults with Crohn’s disease and ulcerative colitis. But Stelara can also be used for other autoimmune conditions, such as psoriatic arthritis and plaque psoriasis.
Both drugs come as an injection given under your skin and an intravenous (IV) infusion (an injection that’s given slowly into your vein). These drugs also have some similar side effects and precautions.
To learn more about how Stelara and Entyvio compare, talk with your doctor. They can tell you about the benefits and risks of each.
Specifically, Entyvio is used in adults to treat moderate to severe:
- Ulcerative colitis. With ulcerative colitis, you have inflammation of your colon (large intestine) and rectum. Symptoms of this condition include diarrhea, fever, abdominal pain, and weight loss.
- Crohn’s disease. With Crohn’s disease, you have inflammation in your digestive tract. This may include any part of it, from your mouth to your intestines and anus. Symptoms can include diarrhea, abdominal cramps, blood in your stools, fever, loss of appetite, and weight loss.
Entyvio is used to reduce the symptoms of these conditions, but it doesn’t cure them.
If you’ve been diagnosed with inflammatory bowel disease (IBD), your doctor may discuss Entyvio with you. It’s a prescription medication used in adults to treat Crohn’s disease and ulcerative colitis.
Ask your doctor for information about the risks and benefits of Entyvio for your condition. Here are a few questions you can ask:
- How long will I need to take Entyvio?
- Do I need to have steady Entyvio levels in my body to keep my condition in remission?
- Does Entyvio cause kidney problems, such as kidney cancer?
- Can I restart Entyvio treatment after stopping it for a while?
- What can I expect when I start treatment with Entyvio?
- Do I need to stop taking Entyvio if I get the flu or another infection?
To learn more about Entyvio, see these articles:
- Dosage Details for Entyvio
- Entyvio and Cost: What You Need to Know
- Side Effects of Entyvio: What You Need to Know
To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters. You may also want to check out the online communities at Bezzy. It’s a place where people with certain conditions can find support and connect with others.
Can I take a multivitamin supplement with Entyvio?Anonymous
It’s probably safe to take a multivitamin supplement with Entyvio.
But to make sure, check with your doctor or pharmacist before taking anything with Entyvio. This includes over-the-counter products, such as multivitamins, and any medications.
Your doctor or pharmacist can help determine if the supplement or medication will interact with Entyvio. If they find problems with the supplement or medication, they may recommend another one that won’t interact with Entyvio.
Be sure your doctor and pharmacist are aware of all the medications and any over-the-counter products you use. This allows them to check for interactions with any drugs you’re taking, including Entyvio.The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.