Elrexfio (elranatamab-bcmm) is a prescription liquid solution that treats multiple myeloma in adults in certain situations. It’s given as an injection under the skin. After the first few doses, you’ll receive one dose every 1 or 2 weeks.
Elrexfio is prescribed to treat multiple myeloma (a type of blood cancer) that’s refractory (hasn’t responded to treatments) or relapsed (returned after treatment). Elrexfio is prescribed after certain other medications have already been tried.
The active ingredient in Elrexfio is elranatamab-bcmm. (The reason “-bcmm” appears at the end of the drug’s name is to show that it’s distinct from similar drugs that may be created in the future.) Elrexfio is a type of immunotherapy and belongs to a group of drugs called bispecific T-cell engagers.
This article describes the dosage of Elrexfio, as well as its strength and how it’s given. To learn more about Elrexfio, see this in-depth article.
What is Elrexfio’s form?
Elrexfio is a liquid solution that comes in single-dose vials.
How is Elrexfio given?
Elrexfio is given as an injection under your skin by a healthcare professional using a syringe and needle. This drug is only given by qualified healthcare professionals at hospitals or healthcare facilities that have a special certification.
What strength does Elrexfio come in?
Elrexfio comes in one strength of 40 milligrams per milliliter of liquid solution (40 mg/mL).
Elrexfio vials are available in two sizes:
- 44 mg/1.1 mL
- 76 mg/1.9 mL
What are the usual dosages of Elrexfio?
The information below describes dosages that are commonly used or recommended. But your doctor will determine the best dosage to fit your needs.
Dosage for multiple myeloma
You’ll likely stay in the hospital for the first few doses of Elrexfio treatment. This way, your doctor and other healthcare professionals can closely monitor you for side effects and provide medical care if necessary.
Before receiving Elrexfio, you’ll likely be given premedications to help prevent or minimize side effects. These premedications usually include acetaminophen (Tylenol), diphenhydramine (Benadryl), and a steroid such as dexamethasone.
Elrexfio treatment begins with two step-up doses. These are lower doses that are given to see how your body responds to the drug. The first step-up dose of 12 mg is given on day 1. The second step-up dose is 32 mg, given on day 4. Then, the first treatment dose of 76 mg is given on day 8.
In some cases, your doctor may adjust your step-up dosage schedule. It depends on how your body responds to Elrexfio treatment.
After the step-up doses, you’ll likely receive 76 mg of Elrexfio once per week. After completing 24 weeks of treatment, some people may be switched to a biweekly dosing schedule. This dosage is 76 mg of Elrexfio given once every 2 weeks.
Is Elrexfio used long term?
Yes, Elrexfio is usually a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely receive it long term.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.