Elahere (mirvetuximab soravtansine-gynx) is a prescription drug that’s used to treat certain types of cancer. This drug can interact with other medications. For example, Elahere can interact with ketoconazole and clarithromycin.
Elahere is used in adults to treat certain forms of:
Elahere contains the active ingredient mirvetuximab soravtansine-gynx.* (An active ingredient is what makes a drug work.) Elahere comes as a liquid solution that’s given by a healthcare professional as an intravenous (IV) infusion. (An IV infusion is an injection into a vein over a period of time.)
An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.
Keep reading to learn about Elahere’s possible interactions. And for more information about Elahere, including details about its uses, see this article.
* The reason “-gynx” appears at the end of the drug’s name is to show that the drug is distinct from similar medications that may be created in the future.
Before you start Elahere treatment, tell your doctor about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Elahere interacts with supplements, herbs, and vitamins, see the “Are there other interactions with Elahere?” section below.)
If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.
The table below lists drugs that may interact with Elahere. Keep in mind that this table does not include all drugs that may interact with Elahere. For more information about some of these interactions, see the “Drug interactions explained” section below.
| Drug group or drug name | Drug examples | What can happen |
| certain antifungal drugs | • ketoconazole • itraconazole (Sporanox, Tolsura) | can increase the risk of side effects from Elahere |
| certain HIV medications | • ritonavir (Norvir) • cobicistat (Tybost) and drugs that contain it | can raise the risk of side effects from Elahere |
| certain antibiotic drugs | • clarithromycin • erythromycin (Eryc, Ery-tab) | can increase the risk of side effects from Elahere |
| certain heart drugs | • diltiazem (Cardizem CD, others) • verapamil (Verelan, others) | can increase the risk of side effects from Elahere |
| ceritinib (Zykadia) | – | can raise the risk of side effects from Elahere |
| cobicistat (Tybost) and drugs that contain it | • Stribild (cobicistat/elvitegravir/emtricitabine/tenofovir disoproxil fumarate) • Genvoya (cobicistat/elvitegravir/emtricitabine/tenofovir alafenamide fumarate) | can increase the risk of side effects from Elahere |
| idelalisib (Zydelig) | – | can increase the risk of side effects from Elahere |
| nefazodone | – | can raise the risk of side effects from Elahere |
Certain health conditions or other factors could raise your risk of harm if you take Elahere. In such cases, your doctor may not prescribe Elahere for you. These are known as contraindications. Elahere’s contraindication is described below.
If you’ve had an infusion reaction or an allergic reaction. If you’ve had an infusion reaction or allergic reaction to Elahere or any of its ingredients, your doctor may adjust your dosage or have you stop treatment. This is because receiving Elahere could cause another reaction. You can ask your doctor about any treatment modifications or other medications that may be better options for you.
Elahere is not known to interact with alcohol. But Elahere and alcohol can cause some similar side effects, such as nausea and fatigue (low energy). You may be more likely to experience these side effects if you drink alcohol during your Elahere treatment.
If you have questions about consuming alcohol during Elahere treatment, talk with your doctor or pharmacist.
Learn more about certain drug interactions that can occur with Elahere.
Interaction with certain antifungal drugs
Elahere can interact with certain antifungal drugs that help treat fungal infections.
Examples of antifungal medications known to interact with Elahere include:
- ketoconazole
- itraconazole (Sporanox, Tolsura)
- posaconazole (Noxafil)
- voriconazole (Vfend)
What could happen
Combining Elahere with certain antifungals can increase the level of Elahere in your body. This may raise your risk of side effects from the drug, including severe eye problems such as impaired vision. This happens because some antifungal drugs reduce the activity of certain enzymes that help remove Elahere from your body.
What you can do
If you take Elahere with the antifungal drugs mentioned above, your doctor will closely monitor you for symptoms of side effects during your Elahere treatment.
If you have questions about using Elahere with antifungal drugs, talk with your doctor or pharmacist.
Interaction with certain HIV medications
Elahere can interact with certain HIV medications. Examples of HIV medications known to interact with Elahere include:
What could happen
Combining Elahere with certain HIV medications can raise the level of Elahere in your body. This can raise your risk of side effects from the drug, including severe eye problems such as impaired vision. This happens because certain HIV medications reduce the activity of certain enzymes that help remove Elahere from your body.
What you can do
If you take Elahere with the HIV drugs mentioned above, your doctor will closely monitor you for side effects from Elahere.
If you have questions about receiving Elahere with HIV medications, talk with your doctor or pharmacist.
Interaction with certain heart drugs
Elahere can interact with the heart drugs diltiazem (Cardizem CD, others) and verapamil (Verelan, others). These drugs are used to treat certain heart arrhythmias, as well as high blood pressure and angina (a type of chest pain).
What could happen
Combining Elahere with diltiazem or verapamil can raise the level of Elahere in your body. This can raise your risk of side effects from Elahere, including severe eye problems such as impaired vision. This is because diltiazem and verapamil reduce the activity of certain enzymes that help clear Elahere from your body.
What you can do
If you take Elahere with diltiazem or verapamil, your doctor will closely monitor you for side effects of Elahere.
If you have questions about using Elahere with heart drugs, talk with your doctor or pharmacist.
Elahere may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Elahere.
Does Elahere interact with supplements?
Before you start Elahere treatment, talk with your doctor and pharmacist about any supplements, herbs, and vitamins you take. Sharing this information with them may help you avoid possible interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Elahere and herbs
There are currently no reports of Elahere interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.
For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products during your Elahere treatment.
Elahere interactions with vitamins
There are currently no reports of Elahere interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.
For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while using Elahere.
Does Elahere interact with food?
Grapefruit and grapefruit juice may interact with Elahere if consumed in large quantities.
This interaction can happen because grapefruit and grapefruit juice can reduce the activity of certain enzymes that help remove Elahere from your body. But you have to consume a large amount of grapefruit or grapefruit juice per day to have this effect.
If you consume grapefruit products regularly, talk with your doctor or pharmacist before starting Elahere treatment. They can recommend an amount that’s safe to consume during treatment.
Does Elahere interact with vaccines or lab tests?
There are currently no reports of Elahere interacting with vaccines or lab tests. If you have questions about receiving certain vaccines or having lab tests done during your Elahere treatment, talk with your doctor.
Does Elahere interact with cannabis or CBD?There are currently no reports of Elahere interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Elahere.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Certain medical conditions or other health factors may raise the risk of interactions with Elahere. Before using Elahere, talk with your doctor about your health history. They’ll determine whether Elahere is right for you.
Health conditions or other factors that might interact with Elahere include:
Eye condition or vision problems. Treatment with Elahere may cause severe eye problems, including worsening vision and eye pain. (Elahere has a
If you have an existing eye or vision problem, such as impaired vision or cataracts, receiving Elahere may worsen your condition. You may also have a higher risk of new eye problems with Elahere. Talk with your doctor to learn more about whether Elahere is safe to receive with your eye condition.
Liver condition. Doctors typically won’t prescribe Elahere if you have a moderate or severe liver condition, such as cirrhosis. Your liver helps remove Elahere from your body. Having liver problems can cause the level of Elahere to build up in your system. This raises your risk of side effects from the drug, including severe ones such as eye problems. Your doctor can provide more information on whether your liver is healthy enough for treatment with Elahere.
Pregnancy. Elahere is not safe to receive during pregnancy. The drug could cause harm to a fetus, including pregnancy loss. If you’re pregnant or planning a pregnancy, talk with your doctor before using Elahere. If you can become pregnant, your doctor will order a pregnancy test to make sure you’re not pregnant before prescribing Elahere for you. They’ll also advise you to use birth control during treatment and for at least 7 months after your last dose.
Breastfeeding. You should not breastfeed during Elahere treatment and for at least 1 month following your last dose. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.
Allergic reaction. If you’ve had an allergic reaction to Elahere or any of its ingredients, your doctor will likely not prescribe Elahere. This is because using the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.
Taking certain steps can help you avoid interactions with Elahere. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:
- Whether you drink alcohol or use cannabis.
- Other medications you take, as well as any vitamins, supplements, and herbs. Your doctor or pharmacist can help you fill out a
medication list . - What to do if you start taking a new drug during your Elahere treatment.
It’s also important to understand Elahere’s
If you have trouble reading or understanding this information, your doctor or pharmacist can help.
Using Elahere exactly as prescribed can also help prevent interactions.
If you still have questions about Elahere and its possible interactions, talk with your doctor.
Questions you may want to ask your doctor include:
- Do I have a higher risk for interactions with Elahere based on my health history?
- Do other medications that could treat my condition have similar interactions to Elahere?
- Do I need to tell you if I start taking another medication or supplement during my Elahere treatment?
- If I have a fungal infection while taking Elahere, are there treatment options that don’t interact with Elahere?
To learn more about Elahere, see these articles:
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.