Dexilant (dexlansoprazole) is a prescription drug that’s used to reduce stomach acid caused by certain conditions. This drug can interact with other medications and some supplements. For example, Dexilant can interact with warfarin and methotrexate.

Dexilant is used in adults and certain children to:

Dexilant contains the active ingredient dexlansoprazole. The drug comes as a delayed-release oral capsule. (“Delayed release” means the drug is released into your body slowly over time.)

An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.

Keep reading to learn about Dexilant’s possible interactions. And for more information about Dexilant, including details about its uses, see this article.

Before you start taking Dexilant, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Dexilant interacts with herbs or vitamins and supplements, see the “Are there other interactions with Dexilant?” section below.)

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

The table below lists drugs that may interact with Dexilant. Keep in mind that this table does not include all drugs that may interact with Dexilant. For more information about some of these interactions, see the “Drug interactions explained” section below.

Drug group or drug nameDrug examplesWhat can happen
certain HIV drugs• atazanavir (Reyataz)
• nelfinavir (Viracept)
• rilpivirine* (Edurant, others)
• cobicistat (Tybost, others)
• ritonavir (Norvir, others)
can make the HIV drug less effective or increase the risk of side effects from Dexilant
certain seizure medicationscarbamazepine (Tegretol, others)
phenytoin (Dilantin)
can make Dexilant less effective
certain antifungalsitraconazole (Sporanox)
ketoconazole
• voriconazole (Vfend)
can make the antifungal less effective or increase the risk of side effects from Dexilant
certain cancer drugs• dasatinib (Sprycel)
erlotinib
• nilotinib (Tasigna)
can make the cancer drug less effective
digoxin (Lanoxin)can increase the risk of side effects from digoxin
methotrexate (Trexall, others)can increase the risk of side effects from methotrexate
mycophenolate mofetil (CellCept)can make mycophenolate less effective
tacrolimus (Prograf, Astagraf XL)can increase the risk of side effects from tacrolimus
warfarin (Jantoven)can increase the risk of side effects from warfarin

* Dexilant should not be taken with rilpivirine. See “When should I avoid Dexilant?” below for more information.

Certain health conditions or other factors could raise your risk of harm if you take Dexilant. In such cases, your doctor may not prescribe Dexilant for you. These are known as contraindications. The list below includes contraindications of Dexilant.

If you take rilpivirine: If you take an HIV medication that contains rilpivirine (such as Edurant or Cabenuva), your doctor likely won’t prescribe Dexilant for you. This is because Dexilant lowers the amount of rilpivirine in your body, which could make rilpivirine less effective. You can ask your doctor about other treatments that may be better options for you.

If you’ve had an allergic reaction: If you’ve had an allergic reaction to Dexilant, any of its ingredients, or a similar drug called lansoprazole (Prevacid), your doctor likely won’t prescribe Dexilant for you. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.

Before you start taking Dexilant, talk with your doctor if any of the factors above apply to you. Your doctor can determine whether Dexilant is safe for you to take.

Dexilant is not known to interact with alcohol. But your doctor may recommend avoiding or limiting alcohol while you’re taking it. Drinking alcohol can worsen symptoms of GERD and erosive esophagitis, which Dexilant is used to treat.

If you have questions about consuming alcohol while taking Dexilant, talk with your doctor or pharmacist.

Learn more about certain drug interactions that can occur with Dexilant.

Interaction with digoxin

Dexilant can interact with digoxin, which is used to treat certain heart conditions, such as heart failure and irregular heartbeats.

What could happen

Taking Dexilant with digoxin can cause your body to break down digoxin too slowly, which can raise the level of digoxin in your body. This increases your risk of side effects from digoxin, such as:

  • diarrhea
  • vomiting
  • changes in your vision
  • fast or irregular heartbeat
  • confusion

If you are dehydrated or have kidney problems, you may have a higher risk of side effects if you take Dexilant with digoxin. If you have low potassium or magnesium levels, you may have a higher risk of irregular heartbeat if you take Dexilant with digoxin. (And keep in mind that Dexilant can sometimes cause low magnesium levels.)

What you can do

If you take Dexilant with digoxin, your doctor will likely monitor the levels of magnesium and digoxin in your blood. If needed, they may prescribe a lower dosage of digoxin for you. You should not take a higher dose of either medication than your doctor prescribes.

If you take Dexilant and digoxin together, tell your doctor right away if you have symptoms of high digoxin levels. These may include the side effects of digoxin that are listed above in this section.

If you have questions about taking Dexilant with digoxin, talk with your doctor or pharmacist.

Interaction with methotrexate

Dexilant can interact with methotrexate (Trexall, Otrexup, others), which is used to treat certain cancers and autoimmune conditions such as rheumatoid arthritis and psoriasis.

What could happen

Taking Dexilant with methotrexate can cause your body to break down methotrexate too slowly, causing methotrexate to build up in your system. This can raise your risk of side effects from methotrexate, such as:

If you are dehydrated or have kidney problems, you may have a higher risk of side effects from methotrexate if you take Dexilant with methotrexate.

What you can do

If you take Dexilant with methotrexate, your doctor will likely monitor you closely for side effects during your treatment. If needed, they may also have you stop taking Dexilant and switch to another medication.

If you take Dexilant and methotrexate together, tell your doctor right away if you have side effects of methotrexate, which are listed above.

If you have questions about taking these drugs together, talk with your doctor or pharmacist.

Interaction with warfarin

Dexilant can interact with warfarin (Jantoven), which is a blood thinner used to treat and help prevent blood clots.

What could happen

Taking Dexilant with warfarin can increase the level of warfarin in your body. This can raise your risk of bleeding.

What you can do

If you take Dexilant with warfarin, your doctor will likely monitor your international normalized ratio (blood clotting time) more often than usual. If needed, they may prescribe a lower dosage of warfarin for you. You should not take a higher dose of either medication than your doctor prescribes.

If you take Dexilant and warfarin together, tell your doctor right away if you have symptoms of bleeding. These may include:

Dexilant may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Dexilant.

Does Dexilant interact with supplements?

Before you start taking Dexilant, talk with your doctor and pharmacist about any herbs or vitamins and supplements you take. Sharing this information with them may help you avoid possible interactions.

Dexilant can interact with iron supplements. Taking Dexilant with iron supplements can prevent these supplements from being absorbed into your body correctly. That’s because Dexilant reduces stomach acid, and stomach acid is needed for your body to absorb iron supplements. If you take iron supplements, talk with your doctor before starting Dexilant treatment.

If you have questions about other interactions that may affect you, talk with your doctor or pharmacist.

Dexilant interactions with herbs

Dexilant can interact with St. John’s wort, which is used to ease symptoms of depression and other conditions.

Taking Dexilant with St. John’s wort can cause your body to break down Dexilant too quickly. This lowers the amount of Dexilant in your system, which can make it less effective. Your doctor will likely recommend that you do not take St. John’s wort with Dexilant.

Dexilant interactions with vitamins

There are currently no reports of Dexilant interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Dexilant.

Does Dexilant interact with food?

Dexilant may interact with grapefruit and grapefruit juice. Consuming grapefruit with Dexilant may cause your body to break down Dexilant too slowly. This could raise your risk of side effects from the drug. Your doctor may recommend avoiding or limiting grapefruit products while taking Dexilant.

Dexilant can prevent your body from absorbing vitamin B12 correctly from foods that contain it. That’s because Dexilant reduces stomach acid, and stomach acid is needed for your body to absorb vitamin B12. If you take Dexilant for more than 3 years, this may lead to vitamin B12 deficiency in rare cases.

Talk with your doctor if you have symptoms of vitamin B12 deficiency. These may include:

  • fatigue
  • weakness
  • reduced appetite
  • tingling in your hands or feet

If you have questions about eating certain foods during your treatment with Dexilant, talk with your doctor.

Does Dexilant interact with vaccines?

There are currently no reports of Dexilant interacting with vaccines. If you have questions about getting certain vaccines during your Dexilant treatment, talk with your doctor.

Does Dexilant interact with lab tests?

Dexilant can interact with the following lab tests:

  • Blood tests for serum chromogranin A (CgA) levels: These tests are used to help diagnose neuroendocrine tumors.
  • Secretin stimulation test: This test helps diagnose stomach cancers.
  • Urine screening tests for tetrahydrocannabinol (THC): These tests are used to test for cannabis use.

If you need to have any of these lab tests done, be sure to tell the healthcare professional ordering the test that you’re taking Dexilant.

If you have questions about Dexilant’s effect on lab tests, talk with your doctor.

Does Dexilant interact with cannabis or CBD?

There are currently no reports of Dexilant interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). However, cannabis has been specifically reported to interact with a very similar drug called lansoprazole (Prevacid).

Taking cannabis with lansoprazole can increase the amount of lansoprazole in your body. This may raise your risk of side effects from the drug. So taking cannabis with Dexilant may have the same effect.

Before you start treatment with Dexilant, tell your doctor and pharmacist if you use cannabis. By sharing this information with them, you may help prevent possible interactions.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions or other health factors may raise the risk of interactions with Dexilant. Before taking Dexilant, talk with your doctor about your health history. They’ll determine whether Dexilant is right for you.

Health conditions or other factors that might interact with Dexilant include:

Liver problems. Your liver helps clear Dexilant from your body. If you have liver problems, Dexilant levels could build up in your body. As this could raise your risk of side effects, your doctor may prescribe a lower dosage of Dexilant for you. But if you have severe liver problems, your doctor likely won’t prescribe Dexilant for you.

Low level of certain electrolytes. If you have low levels of magnesium, calcium, or potassium in your blood, taking Dexilant for a long time could make this worse. Your doctor may order blood tests to check your electrolyte levels before and during your Dexilant treatment.

Lupus. If you have lupus, taking Dexilant could worsen your lupus symptoms, such as joint pain or skin rash. Talk with your doctor about whether Dexilant is right for you.

Pregnancy. It’s not known whether Dexilant is safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before taking Dexilant.

Breastfeeding. It’s not known whether it’s safe to take Dexilant while breastfeeding. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.

Allergic reaction. If you’ve had an allergic reaction to Dexilant, any of its ingredients, or a similar drug called lansoprazole (Prevacid), your doctor will likely not prescribe Dexilant. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.

Find answers to some frequently asked questions about Dexilant and possible interactions.

Can I take Dexilant and omeprazole together?

There’s no known interaction between Dexilant and omeprazole (Prilosec). However, these drugs are not typically used together. They belong to the same group of drugs called proton pump inhibitors.

Dexilant and omeprazole are both prescribed to treat GERD and erosive esophagitis. Omeprazole has other uses as well. It’s available over the counter (OTC) to treat heartburn.

Doctors are unlikely to prescribe Dexilant and omeprazole together. That’s because these drugs work in the same way and can cause similar side effects. You should not take OTC omeprazole while you’re taking Dexilant. If you have questions, talk with your doctor or pharmacist.

Is it safe to take antacids with Dexilant?

Yes, it should be safe to take antacids with Dexilant. There’s no known interaction between these drugs. They both reduce stomach acid, but they work in different ways.

Dexilant is used to treat GERD and erosive esophagitis. Antacids are used to relieve indigestion and heartburn.

Indigestion and heartburn are common symptoms of GERD and erosive esophagitis. Taking Dexilant should help relieve these symptoms. But if the drug doesn’t completely ease your symptoms, it’s safe to take antacids as well.

If you have other questions about taking Dexilant and antacids together, talk with your doctor or pharmacist.

Taking certain steps can help you avoid interactions with Dexilant. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:

  • Whether you drink alcohol or use cannabis.
  • Other medications you take, as well as any vitamins, supplements, and herbs. Your doctor or pharmacist can help you fill out a medication list.
  • What to do if you start taking a new drug during your Dexilant treatment.

It’s also important to understand Dexilant’s label and other paperwork that may come with the drug. Colored stickers that describe interactions may be on the label. And the paperwork (sometimes called the patient package insert or medication guide) may have other details about interactions. (If you did not get paperwork with Dexilant, ask your pharmacist to print a copy for you.)

If you have trouble reading or understanding this information, your doctor or pharmacist can help.

Taking Dexilant exactly as prescribed can also help prevent interactions.

If you still have questions about Dexilant and its possible interactions, talk with your doctor.

Questions you may want to ask your doctor include:

  • Do other drugs that could treat my condition have similar interactions to Dexilant?
  • Should I let you know if I make lifestyle changes during my treatment, such as to my diet or exercise routine?
  • Can I take pain relievers with Dexilant?

To learn more about Dexilant, see these articles:

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.