Cyltezo (adalimumab-adbm) is a prescription injection that’s used to treat certain autoimmune conditions. The drug comes as a liquid solution in a prefilled syringe or injection pen. It’s usually given once every 2 weeks.

Doctors prescribe Cyltezo to treat certain autoimmune conditions in adults, including:

Cyltezo is also prescribed to treat the following autoimmune conditions in children:

Cyltezo belongs to a group of drugs called tumor necrosis factor (TNF) blockers. It’s a biologic drug, which means it’s made from living cells. Cyltezo is a biosimilar of the brand-name biologic Humira (adalimumab). (Biosimilars are like generics, but unlike generics, biosimilars are made for biologic drugs.)

The active ingredient in Cyltezo is adalimumab-adbm.† (An active ingredient is what makes a drug work.)

This article describes the dosages of Cyltezo, as well as its strengths and how to administer it. To learn more about Cyltezo, see this in-depth article.

* Cyltezo has a limitation when prescribed for UC. It’s not known how effective the drug is for the treatment of UC when given to people whose bodies didn’t respond to or couldn’t tolerate other TNF blockers.

† Biosimilars have the same active ingredient core name as the brand-name drug. But they have unique suffixes. This is why “adbm” appears at the end of the active ingredient name. This is to show that it’s distinct from the brand-name biologic and from other biosimilars.

This section describes the usual dosages of Cyltezo. Keep reading to learn more.

What are Cyltezo’s forms?

Cyltezo comes as a liquid solution for injection under your skin. Cyltezo is available in a prefilled injection pen or prefilled glass syringe.

What strengths does Cyltezo come in?

Cyltezo comes in different strengths, depending on whether it’s in an injection pen or glass syringe.

The injection pen contains 40 milligrams (mg) of Cyltezo in 0.8 milliliters (mL) of liquid solution.

Three strengths are available in the prefilled glass syringes:

  • 10 mg of Cyltezo per 0.2 mL of liquid solution
  • 20 mg of Cyltezo per 0.4 mL of liquid solution
  • 40 mg of Cyltezo per 0.8 mL of liquid solution

What are the usual dosages of Cyltezo for adults?

Your doctor will prescribe your dosage of Cyltezo based on the condition they have prescribed it to treat.

The information below describes dosages that are commonly prescribed or recommended. But be sure to follow the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosage for Crohn’s disease

When you start Cyltezo for the treatment of Crohn’s disease, your doctor will prescribe two or three loading doses. These are higher-than-usual doses that are given over the first 15 days of treatment to help the drug start working quickly. The schedule is usually like this:

  • 160 mg on day 1, or 80 mg on day 1 and 80 mg on day 2
  • 80 mg on day 15

Then, starting on day 29, you’ll receive 40 mg of Cyltezo once every 2 weeks.

Dosage for psoriatic arthritis

For treatment of psoriatic arthritis, the usual dosage is 40 mg of Cyltezo to be given once every 2 weeks.

Dosage for rheumatoid arthritis

For treatment of rheumatoid arthritis, the usual dosage is 40 mg of Cyltezo to be given once every 2 weeks.

Dosage for ulcerative colitis

If you’re prescribed Cyltezo for treatment of ulcerative colitis, your doctor will likely first prescribe two or three loading doses. These are higher-than-usual doses that are given over the first 15 days of treatment to help the drug start working quickly. The schedule is usually like this:

  • 160 mg on day 1, or 80 mg on day 1 and 80 mg on day 2
  • 80 mg on day 15

Then, starting on day 29, you’ll receive 40 mg of Cyltezo once every 2 weeks.

Dosage for plaque psoriasis

For treatment of plaque psoriasis, your doctor will first give you an 80-mg loading dose of Cyltezo. Then, 1 week after your first dose, you’ll receive a 40-mg dose of Cyltezo. After that, you’ll receive 40 mg of Cyltezo once every 2 weeks.

Dosage for ankylosing spondylitis

For treatment of ankylosing spondylitis, the usual dosage is 40 mg of Cyltezo to be given once every 2 weeks.

Dosage for hidradenitis suppurativa

If you’re prescribed Cyltezo for treatment of hidradenitis suppurativa, your doctor will likely first prescribe two or three loading doses. These are higher-than-usual doses that are given over the first 15 days of treatment to help the drug start working quickly. The schedule is usually like this:

  • 160 mg on day 1, or 80 mg on day 1 and 80 mg on day 2
  • 80 mg on day 15

Then, starting on day 29, you’ll receive 80 mg of Cyltezo once every 2 weeks or 40 mg once every week.

What’s the dosage of Cyltezo for children?

Cyltezo’s dosage in children depends on the condition it’s being prescribed to treat. Your child’s dosage also depends on their body weight.

Children’s dosage for juvenile idiopathic arthritis

Cyltezo is prescribed to treat juvenile idiopathic arthritis in children ages 2 years and older. The table below lists usual dosages based on your child’s body weight. For reference, 1 kilogram (kg) equals about 2.2 pounds (lb).

Body weightMaintenance dosage
10–15 kg10 mg once every 2 weeks
15–30 kg20 mg once every 2 weeks
30 kg and greater40 mg once every 2 weeks

If you have questions about your child’s dosage of Cyltezo, talk with their doctor.

Children’s dosage for Crohn’s disease

Cyltezo may be given to treat Crohn’s disease in children ages 6 years and older. If your child is prescribed Cyltezo for treatment of Crohn’s disease, their doctor will likely first prescribe two or three loading doses. These are higher-than-usual doses that are given over the first 15 days of treatment to help the drug start working quickly.

The table below lists usual dosages based on your child’s body weight.

Body weightInitial doseDose on day 15Maintenance dosage, beginning on day 29
17–40 kg• 80 mg on day 140 mg20 mg once every 2 weeks
40 kg and greater• 160 mg on day 1, or
• 80 mg on day 1 and 80 mg on day 2
80 mg40 mg once every 2 weeks

If you have questions about your child’s dosage of Cyltezo, talk with their doctor.

Is Cyltezo prescribed long term?

Yes, Cyltezo is usually prescribed as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely be prescribed it long term.

The dosage of Cyltezo you’re prescribed may depend on several factors. These include:

  • the type and severity of the condition you’re prescribed the drug to treat
  • your age
  • other medications you may be taking

And when prescribed for children, the dosage also depends on their body weight.

Cyltezo is available as a liquid solution that’s given as an injection under your skin. It comes in a prefilled injection pen or glass syringe.

Your doctor or another healthcare professional will give you your first dose of Cyltezo. While doing so, they’ll instruct you on how to give yourself injections at home. After that, you’ll be able to inject Cyltezo at home.

You’ll inject Cyltezo under the skin of your thigh or abdomen (at least 2 inches away from your belly button). It’s important to rotate injection sites. This helps decrease irritation and lowers your risk of certain side effects, such as pain or bleeding at the injection site.

You can learn more about giving your doses of Cyltezo from the manufacturer’s instructions for use. You can also call 800-542-6257 if you have any questions or concerns.

For information on the expiration, storage, and disposal of Cyltezo, talk with your doctor or pharmacist.

Accessible drug containers and labels

Some pharmacies provide medication labels that:

  • have large print
  • use braille
  • feature a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

If you miss a dose of Cyltezo, inject it as soon as you remember. Then continue with your next regularly scheduled dose. If you’re not sure whether you should inject or skip a dose, talk with your doctor or pharmacist.

If you need help remembering to inject your dose of Cyltezo, try using a medication reminder. This can include setting an alert on your phone calendar or reminder app.

Do not inject more Cyltezo than your doctor prescribes, as this can lead to harmful effects.

What to do in case you inject too much Cyltezo

Call your doctor right away if you think you’ve injected too much Cyltezo. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Below are answers to some commonly asked questions about Cyltezo’s dosage.

Is Cyltezo’s dosage similar to Humira’s dosage?

Yes, it is. Humira (adalimumab) is a brand-name biologic drug. Cyltezo is its biosimilar.* The two drugs have the same form, and for many conditions, their recommended dosages are the same.

Both drugs come as a liquid solution and are given as an injection under the skin. Both are available in prefilled syringes and injection pens, but Humira is also available in a vial that can be drawn from.

There are some differences between the two drugs. For example, Humira may be prescribed to treat ulcerative colitis and hidradenitis suppurativa in some children, but Cyltezo is only prescribed to treat these conditions in adults.

If you have questions about how Cyltezo compares with Humira, talk with your doctor.

* A biologic drug is made from living cells, while other drugs are made from chemicals. Drugs made from chemicals can have generics, which are exact copies of the active ingredient in the brand-name medication. Biologics, on the other hand, can’t be copied exactly. Therefore, instead of a generic, biologics have biosimilars. Biosimilars are “similar” to the parent drug, and they’re considered to be just as effective and safe.

How long does it take for Cyltezo to start working?

Cyltezo starts to work after your first dose. Because of how the medication works, you likely won’t feel it working in your body. However, depending on the condition it’s treating, you may notice reduced symptoms within a few weeks or months.

Talk with your doctor to learn more about what to expect during your Cyltezo treatment.

The sections above describe the usual dosages provided by the manufacturer. If your doctor recommends Cyltezo for you, they’ll prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Cyltezo without your doctor’s recommendation. Only inject Cyltezo exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • Would you adjust my dosage of Cyltezo if I experience certain side effects?
  • If I have Crohn’s disease. Could Cyltezo help my condition go into remission?
  • Will my child’s dosage of Cyltezo need to change if they gain or lose weight?

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.