Auvelity (dextromethorphan/bupropion) is a prescription extended-release oral tablet used to treat depression in adults. This drug can interact with alcohol and other medications. For example, Auvelity can interact with lisdexamfetamine (Vyvanse) and opioids.

Before you start taking Auvelity, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Auvelity interacts with herbs or vitamins and supplements, see the “Are there other interactions with Auvelity?” section below.)

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

The table below lists drugs that may interact with Auvelity. Keep in mind that this table does not include all drugs that may interact with Auvelity. For more information about some of these interactions, see the “Drug interactions explained” section below.

Drug group or drug nameDrug examplesWhat can happen
monoamine oxidase inhibitors (MAOIs)*• intravenous methylene blue (ProvayBlue)
• linezolid (Zyvox)
• phenelzine (Nardil)
• selegiline (Emsam)
can increase the risk of serious
side effects from Auvelity
stimulants • amphetamine/ dextroamphetamine (Adderall)
• lisdexamfetamine (Vyvanse)
• methylphenidate (Ritalin, others)
• modafinil (Provigil)
can increase the risk of seizures with Auvelity
opioidshydrocodone (Hysingla ER, others)
• morphine (MS Contin, others)
tramadol (Ultram, ConZip)
can increase the risk of side effects from Auvelity and opioids
antipsychotics• chlorpromazine
• clozapine (Clozaril)
• thioridazine
can increase the risk of side effects from Auvelity and antipsychotics
tricyclic antidepressants (TCAs)amitriptyline
clomipramine (Anafranil)
nortriptyline (Pamelor)
can increase the risk of side effects from Auvelity and TCAs
selective serotonin reuptake inhibitors (SSRIs)citalopram (Celexa)
• fluoxetine (Prozac)
paroxetine (Paxil)
can increase the risk of side effects from Auvelity and SSRIs
serotonin-norepinephrine reuptake inhibitors (SNRIs)• desvenlafaxine (Pristiq)
• duloxetine (Cymbalta)
• venlafaxine (Effexor XR)
can increase the risk of side effects from Auvelity and SNRIs
dopamine agonistsamantadine
• levodopa
can increase the risk of side effects from Auvelity and dopamine agonists
metoclopramide (Reglan)can increase the risk of side effects from metoclopramide
digoxin (Lanoxin) can make digoxin less effective

* You should not take Auvelity with an MAOI. For more information, see the “When should I avoid Auvelity?” section below.

Certain health conditions or other factors could raise your risk of harm if you take Auvelity. In such cases, your doctor may not prescribe Auvelity for you. These are known as contraindications. The list below includes Auvelity’s contraindications.

If you have a seizure disorder: If you have a disorder that causes seizures, such as epilepsy, your doctor likely won’t prescribe Auvelity for you. This is because taking Auvelity can raise your risk of having seizures. You can ask your doctor about other treatments that may be better options for you.

If you’ve had an eating disorder: If you’ve had an eating disorder before, such as bulimia or anorexia nervosa, your doctor likely won’t prescribe Auvelity for you. This is because taking Auvelity could raise your risk of having seizures. Talk with your doctor about other treatment options.

If you’ve suddenly stopped drinking alcohol or taking certain drugs: If you’ve been dependent on alcohol, benzodiazepines, barbiturates, or seizure medications, suddenly stopping these drugs can raise your risk of seizures. Auvelity can also raise your risk of seizures.

Due to this combined risk, your doctor likely won’t prescribe Auvelity if you’ve suddenly stopped drinking alcohol or taking one of these drugs recently. Talk with your doctor about other treatments that may be better options for you.

If you take an MAOI drug: If you take an MAOI, your doctor likely won’t prescribe Auvelity for you. This is because taking Auvelity with an MAOI can make your blood pressure become dangerously high. It can also increase your risk of serotonin syndrome. This is a serious side effect that can happen if there’s a buildup of serotonin in your body.

If your doctor has you switch from taking an MAOI to treat your depression to taking Auvelity, you’ll usually need to wait at least 2 weeks after stopping the MAOI before starting Auvelity treatment. Examples of MAOIs include linezolid (Zyvox) and phenelzine (Nardil).

If you’ve had an allergic reaction: If you’ve had an allergic reaction to Auvelity or any of its ingredients, your doctor likely won’t prescribe Auvelity for you. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.

Before you start taking Auvelity, talk with your doctor if any of the factors above apply to you. Your doctor can determine whether Auvelity is safe for you to take.

If you drink alcohol, you should avoid drinking it or limit the amount you consume during your Auvelity treatment.

Auvelity can make your body more sensitive to the effects of alcohol. Combining alcohol with Auvelity can also cause changes in your mental health. And drinking excessively while taking Auvelity can increase your risk of seizures.

It’s important to note that drinking alcohol can also worsen symptoms of depression, which Auvelity is used to treat.

If you have questions about consuming alcohol while taking Auvelity, talk with your doctor or pharmacist.

Learn more about certain drug interactions that can occur with Auvelity.

Interaction with stimulants such as Vyvanse

Auvelity can interact with lisdexamfetamine (Vyvanse), which is a stimulant drug used to treat attention deficit hyperactivity disorder (ADHD) and binge eating disorder. Auvelity can also interact with other stimulants.

Examples of other stimulants include:

What could happen

Auvelity and stimulants such as Vyvanse can both raise your risk of having seizures. Taking these drugs together can further increase this risk.

If you’ve had a serious head injury or stroke, you may have a higher risk of seizures if you take Auvelity with Vyvanse. Your risk of seizure may also be higher if you have a brain tumor, brain infection, or severe liver problem.

What you can do

If you take Auvelity with Vyvanse, your doctor may prescribe a lower dosage of Auvelity or Vyvanse for you. You should not take a higher dose of either medication than your doctor prescribes.

If you take Auvelity and Vyvanse together, tell your doctor right away if you have symptoms of seizures. These may include:

If you have questions about taking Auvelity with Vyvanse, talk with your doctor or pharmacist.

Interaction with TCAs

Auvelity can interact with TCAs, which are used to treat depression. Some may also be used for other conditions, such as nerve pain.

Examples of TCAs include:

What could happen

Auvelity and TCAs can both increase your risk of seizures. They can also both cause serotonin syndrome. This is a serious side effect that can happen if there’s a buildup of serotonin in your body. Taking these drugs together can raise your risk of these side effects.

Auvelity can also stop your body from breaking down TCAs correctly. Taking Auvelity with one of these drugs can cause levels of the TCA to build up in your body. This can raise your risk of side effects from the TCA, such as sleepiness and dry mouth.

What you can do

If you take Auvelity with a TCA drug, your doctor may prescribe a lower dosage of Auvelity or the TCA for you. You should not take a higher dose of either medication than your doctor prescribes.

If you take Auvelity and a TCA together, tell your doctor right away if you have symptoms of seizures or serotonin syndrome. These may include:

  • staring into space
  • changes in smell or taste
  • twitching, jerking, or shaking movements
  • loss of consciousness
  • diarrhea
  • fast heart rate
  • sweating
  • feeling anxious or agitated

If you have any other bothersome side effects while taking Auvelity with a TCA drug, talk with your doctor or pharmacist.

Interaction with opioids

Auvelity can interact with opioid medications, which are used to relieve moderate to severe pain.

Examples of opioids include:

What could happen

Auvelity and opioids can both increase your risk of seizures. They can also both cause serotonin syndrome. This is a serious side effect that can happen if there’s a buildup of serotonin in your body. Taking these drugs together can raise your risk of these side effects.

Auvelity can also affect the way your body breaks down certain opioids. This could either make the opioid less effective or raise your risk of side effects from the opioid, such as severe sleepiness and slow, shallow breathing.

What you can do

If you take Auvelity with an opioid, your doctor may prescribe a lower dosage of Auvelity for you. You should not take a higher dose of either medication than your doctor prescribes.

If you take Auvelity and an opioid together, tell your doctor right away if you have symptoms of seizures or serotonin syndrome. These may include:

  • staring into space
  • changes in smell or taste
  • twitching, jerking, or shaking movements
  • loss of consciousness
  • diarrhea
  • fast heartbeat
  • sweating
  • feeling anxious or agitated

If you become very sleepy or have slow, shallow breathing while taking Auvelity with an opioid, call 911 or your local emergency number right away.

If you have questions about taking Auvelity with an opioid, talk with your doctor or pharmacist.

Auvelity may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Auvelity.

Does Auvelity interact with supplements?

Before you start taking Auvelity, talk with your doctor and pharmacist about any herbs or vitamins and supplements you take. Sharing this information with them may help you avoid possible interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Auvelity and herbs

There are currently no reports of Auvelity interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Auvelity.

Auvelity and vitamins

There are currently no reports of Auvelity interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Auvelity.

Does Auvelity interact with food?

Auvelity can interact with caffeine, which is found in chocolate and drinks such as teas, coffee, cola, and energy drinks. Consuming large amounts of caffeine with Auvelity can increase your risk of seizures.

You should avoid consuming large amounts of foods or beverages containing caffeine while taking Auvelity.

If you have questions about the interaction between Auvelity and caffeine, talk with your doctor.

Does Auvelity interact with vaccines?

There are currently no reports of Auvelity interacting with vaccines. If you have questions about getting certain vaccines during your Auvelity treatment, talk with your doctor.

Does Auvelity interact with lab tests?

Auvelity can cause false-positive results in urine tests for amphetamines. This means that while taking Auvelity, your urine can test positive for amphetamines, even if you haven’t taken these drugs.

If you have a urine test for amphetamines, be sure to tell the person ordering the test that you’re taking Auvelity.

If you have questions about having other lab tests during your treatment with Auvelity, talk with the healthcare professional ordering the test.

Does Auvelity interact with cannabis or CBD?

Cannabis (commonly called marijuana) and cannabis products, such as cannabidiol (CBD), have been specifically reported to interact with bupropion, which is one of the active drugs in Auvelity.

Cannabis and cannabidiol may increase or decrease the breakdown of bupropion in your body. This can either make Auvelity less effective, or raise your risk of Auvelity side effects.

Before you start treatment with Auvelity, tell your doctor and pharmacist if you use cannabis. By sharing this information with them, you may help prevent possible interactions.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions or other health factors may raise the risk of interactions with Auvelity. Before taking Auvelity, talk with your doctor about your health history. They’ll determine whether Auvelity is right for you.

Health conditions or other factors that might interact with Auvelity include:

Seizure disorders: If you have a seizure disorder such as epilepsy, your doctor will likely not prescribe Auvelity for you.*

Eating disorders: If you’ve had an eating disorder before, such as bulimia or anorexia nervosa, your doctor likely won’t prescribe Auvelity for you.*

Abruptly stopping alcohol or certain drugs: If you’ve suddenly stopped drinking alcohol or treatment with benzodiazepines, barbiturates, or seizure medications, your doctor will likely not prescribe Auvelity for you.*

Bipolar disorder: If you have bipolar disorder, taking Auvelity may raise your risk of having a manic episode. Auvelity is not approved to treat depressive episodes of bipolar disorder. If you or a family member have ever had a manic episode or been diagnosed with bipolar disorder, talk with your doctor about whether Auvelity is right for you.

Suicidal thoughts or behaviors: Auvelity can increase the risk of suicidal thoughts and behaviors in people younger than 25 years old. The drug has a boxed warning for this risk. To learn more, see the “Boxed warning” section at the top of this article.

Head injury, brain tumor, or stroke: If you’ve had a head injury, brain tumor, or stroke, you may have a higher risk of seizures with Auvelity. Talk with your doctor about whether this medication is safe for you.

Kidney problems: If you have kidney problems, levels of Auvelity could build up in your body. This could raise your risk of side effects. If you have kidney problems, your doctor may prescribe a lower dosage of Auvelity for you.

Liver problems: If you have a liver problem that prevents your body from breaking down certain drugs correctly, your doctor may prescribe a lower dosage of Auvelity for you. If you have severe liver problems, you may have a higher risk of seizures with Auvelity. Talk with your doctor about whether Auvelity is right for you.

High blood pressure: If you have high blood pressure, taking Auvelity could worsen your condition. Your doctor will likely monitor your blood pressure closely during your Auvelity treatment.

Closed-angle glaucoma: Auvelity can cause closed-angle glaucoma in certain people. If you’ve been told you have an increased risk of this condition, your doctor will likely not prescribe Auvelity for you. Talk with them about other treatments that may be better options for you.

Pregnancy: Auvelity is not safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor about other treatment options that may be safer for you.

If you become pregnant while taking Auvelity, tell your doctor right away so you can discuss stopping your treatment. You can also talk with them about enrolling in the National Pregnancy Registry for Antidepressants. This registry collects details about pregnancy issues reported with Auvelity. To learn more or sign up, visit the registry website or call 866-961-2388.

Breastfeeding: It’s not safe to take Auvelity while breastfeeding. The drug passes into breast milk, but it isn’t known whether the drug may cause side effects in a child who’s breastfed. If you’re breastfeeding or planning to do so, talk with your doctor about your options.

Allergic reaction: If you’ve had an allergic reaction to Auvelity or any of its ingredients, your doctor will likely not prescribe Auvelity. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.

* To learn more, see the “When should I avoid Auvelity?” section above.

Help is out there

If you or someone you know is in crisis and considering suicide or self-harm, please seek support:

If you’re calling on behalf of someone else, stay with them until help arrives. You may remove weapons or substances that can cause harm if you can do so safely.

If you are not in the same household, stay on the phone with them until help arrives.

Was this helpful?

Find answers to some frequently asked questions about Auvelity and possible interactions.

Is there an interaction between Auvelity and Xanax?

No. There’s no known interaction between Auvelity and Xanax.

Auvelity is prescribed to treat depression in adults. Xanax is prescribed to treat anxiety in adults. It’s not uncommon for doctors to prescribe these drugs together.

If you have questions about taking Auvelity with Xanax, talk with your doctor or pharmacist.

Is it safe to take Auvelity and Lamictal together?

Yes, it should usually be safe to take Auvelity with lamotrigine (Lamictal). There’s no known interaction between these drugs.

Auvelity is used to treat depression in adults. Lamictal is used to treat bipolar disorder in adults. Lamictal is also used to treat epilepsy in adults and certain children.

People who take Lamictal for bipolar disorder may have episodes of depression. It’s not uncommon for doctors to prescribe Auvelity with Lamictal to treat these episodes. However, this is an off-label* use of Auvelity. Auvelity can increase the risk of manic episodes in people with bipolar disorder.

Doctors are unlikely to prescribe Auvelity for people who take Lamictal for epilepsy. That’s because Auvelity can increase the risk of seizures.

If you have other questions about taking Auvelity and Lamictal together, talk with your doctor or pharmacist.

* Off-label use is when doctors prescribe a drug for a purpose other than what it’s approved for.

Taking certain steps can help you avoid interactions with Auvelity. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:

  • Whether you drink alcohol or use cannabis.
  • Other medications you take, as well as any vitamins, supplements, and herbs. Your doctor or pharmacist can help you fill out a medication list.
  • What to do if you start taking a new drug during your Auvelity treatment.

It’s also important to understand Auvelity’s label and other paperwork that may come with the drug. Colored stickers that describe interactions may be on the label. And the paperwork (sometimes called the patient package insert or medication guide) may have other details about interactions. (If you did not get paperwork with Auvelity, ask your pharmacist to print a copy for you.)

If you have trouble reading or understanding this information, your doctor or pharmacist can help.

Taking Auvelity exactly as prescribed can also help prevent interactions.

If you still have questions about Auvelity and its possible interactions, talk with your doctor.

Questions you may want to ask your doctor include:

  • Does my Auvelity dosage affect my risk of interactions?
  • Do I need to check with you before taking over-the-counter medications with Auvelity?
  • Do other antidepressants have similar interactions to Auvelity?

To learn more about Auvelity, see these articles:

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.