Fab CBD Chews, Lazarus Naturals CBD oil, and Moon Mother massage oilShare on Pinterest

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When you think of cannabis, tetrahydrocannabinol (THC) may be the first cannabinoid to come to mind. But there’s another popular cannabinoid to keep on your radar: cannabidiol (CBD).

While much of the research on CBD is new or ongoing, some evidence suggests that CBD may have certain health benefits, like pain relief.

Because of these potential benefits, CBD products of all kinds have flooded the market. It can be tough to separate the great from not-so-good products — let alone understand CBD terminology, like isolate and full-spectrum.

We’ve got you covered with this quick and easy guide to the differences between each form of CBD.

Both full-spectrum CBD and CBD isolate are extracts from the cannabis plant. But even though they come from the same plant, there are still differences.

Full-spectrum CBD products contain small amounts of other cannabinoids, like THC, as well as flavonoids and terpenes, which are beneficial compounds that provide unique scents and flavors.

CBD isolate products go through further refining, so they only contain CBD.

IsolateFull-spectrum
CBDyesyes
THCnoyes
Flavonoidsnoyes
Terpenesnoyes

The entourage effect theory suggests that taking CBD and THC together, along with terpenes, may be more effective than taking either cannabinoid alone. That’s why some people prefer to use full-spectrum CBD.

One 2011 review in the British Journal of Pharmacology found that taking a combination of terpenes and cannabinoids may help with:

The same review also concludes that CBD may help lessen unwanted THC effects, like hunger, anxiety, and sedation.

Research from 2018 found that some of the terpenes and flavonoids found in cannabis may reduce inflammation and offer neuroprotective effects.

However, as with lots of other aspects of CBD, research into the entourage effect is ongoing — and not all of it agrees.

For example, a 2019 study in the journal Cannabis and Cannabinoid Research found no change in CB1 and CB2 cannabinoid receptors, a part of your endocannabinoid system, when terpenes were added to THC.

More research is needed to be able to say for sure how the entourage effect works.

Some people may want to try CBD but are iffy on THC. That’s where CBD isolate comes in, since it’s the purest form of CBD.

Though CBD isolate won’t provide any benefits from the entourage effect, some research suggests that taking CBD alone may still be beneficial.

CBD isolate may be right for you if you:

  • Want a flavorless, odorless product. Though some CBD isolate products have added flavoring, unflavored products should be pretty taste-free.
  • Want to avoid THC altogether.
  • Want to take large doses of CBD.
  • Have to undergo drug testing. Full-spectrum CBD may be more likely to show up on a drug test. However, there may be a slight possibility that isolate products will show up, too. Even “THC-free” CBD products may contain trace amounts of THC.

Full-spectrum CBD may be the right choice if you want:

  • The benefits of the entourage effect. Since the amount of THC will be less than 0.3 percent, you shouldn’t experience any of THC’s psychoactive effects.
  • An earthy flavor profile. You can find flavored full-spectrum products, but unflavored varieties will have a slightly earthy taste.
  • A less refined product. CBD isolate has to go through more refining than full-spectrum THC.

We’ve done the research to bring you our top-rated CBD isolate and full-spectrum picks. These all meet our criteria for quality, safety, and transparency:

  • made with U.S.-grown hemp
  • has been tested by a third-party lab
  • doesn’t contain more than 0.3 percent THC, according to the certificate of analysis (COA)
  • passes testing for heavy metals, pesticides, and molds, according to the COA

We also considered:

  • the manufacturing process and certifications
  • if the ingredients are certified organic
  • brand reputation and consumer trust indicators, such as user reviews and red flags like FDA warning letters or unsupported health claims

Pricing guide

  • $ = under $40
  • $$ = $41–$60
  • $$$ = over $60

Lazarus Naturals High Potency Full-Spectrum CBD Tincture

  • Price: $–$$$
  • CBD potency: 750 milligrams (mg) per 15 milliliter (mL) bottle, 3,000 mg per 60 mL bottle, or 6,000 mg per 120 mL bottle
  • COA: Available on product page

Each bottle of Lazarus Naturals High Potency Full-Spectrum CBD Tincture includes a graduated dropper to accurately dose about 50 mg of CBD per 1 mL serving. The tincture is vegan and contains no artificial flavors, preservatives, or added sweeteners. It’s made with Oregon-grown hemp.

Buy Lazarus Naturals High Potency Full-Spectrum CBD Tincture online.

Moon Mother Hemp Company Massage Oil

  • Price: $$–$$$
  • CBD potency: 500 mg per 2 ounce (oz.) bottle or 1,000 mg per 4 oz. bottle
  • COA: Available online

This topical CBD massage oil is cruelty-free, gluten-free, and soy-free. The hemp used to make the product is organic and sourced from Colorado.

In addition to full-spectrum CBD, it includes relaxing lavender essential oil and moisturizing jojoba oil.

Buy Moon Mother Hemp Company Massage Oil online.

LiftMode Hemp Extract Oil, Calm

  • Price: $
  • CBD potency: 1,500 mg per 30 mL bottle
  • COA: Available online

A half dropper serving of this CBD oil contains about 25 mg of CBD and 1 mg of melatonin. Melatonin can be helpful if you have trouble sleeping.

The oil also includes relaxing chamomile, frankincense, and lavender essential oils. It’s free of GMOs, fillers, and gluten.

Buy LiftMode Hemp Extract Oil, Calm online.

Pure Relief Pure Hemp Gummies

  • Price: $$
  • CBD potency: 30 mg per gummy
  • COA: Available online

These potent CBD gummy bears are available in a daytime formula and a nighttime formula, which has added melatonin.

The gummies are dyed with natural colorings rather than artificial ones. They’re sweetened with organic glucose syrup and cane sugar.

Buy Pure Relief Pure Hemp Gummies online. Use code “HEALTH15” for 15% off (bundles excluded).

Fab CBD Chews

  • Price: $$
  • CBD potency: 25 mg per gummy
  • COA: Available online

These fruit-flavored CBD chews are vegan, non-GMO, and gluten-free. The CBD is sourced from organically grown hemp. They’re sweetened with organic cane sugar and tapioca syrup.

Note that while Fab CBD says these gummies are made from CBD isolate, the COA shows a very small amount of the terpene d-limonene. Even though they don’t contain any other cannabinoids, that suggests that the gummies may be better classified as broad-spectrum.

Buy Fab CBD Chews online. Use code “HEALTHLINE” for 20% off your first purchase.

Kanibi CBD Pure Isolate

  • Price: $$–$$$
  • CBD potency: 750 mg per 1 oz. bottle or 1,500 mg per 1 oz. bottle
  • COA: Available on product page

Kanibi’s CBD isolate is available in cinnamon, Skittles, and unflavored varieties. It’s made with organic, U.S.-grown hemp and MCT oil.

The company provides a 100 percent money-back guarantee.

Buy Kanibi CBD Pure Isolate online. HEALTHLINE10 for 10% off.

Some CBD companies make misleading claims about their products — some even mislabel them. And since the FDA doesn’t regulate CBD products the same way it regulates dietary supplements or drugs, that means it’s super important to do careful research.

Look out for the following when shopping for CBD products:

Test results

Look for products that include an up-to-date COA from a third-party lab. Some companies will ship the COA with the product, while others may post it online. In some cases, you may have to request it by email.

Here’s what to check for when you review the COA:

  • Contaminants. Check that the product doesn’t contain pesticides, mold, or heavy metals.
  • Cannabinoid profile. If you’re interested in purchasing a CBD isolate product, for instance, verify that the product is free of THC.
  • Potency. Check that the amount of CBD listed on the COA matches what’s listed on the label.

Ingredients

Be sure the product you’re buying actually contains CBD. If the ingredients list only says hempseed oil or Cannabis sativa oil, it doesn’t contain CBD.

CBD source

Opt for products made from organic, U.S.-grown hemp. U.S.-grown hemp is subject to regulation, so it can’t contain more than 0.3 percent THC by law.

CBD type

It’s up to you which kind of CBD you choose, but if you prefer to avoid THC, choose a CBD isolate product. If you’d like to have other cannabis compounds, choose a full-spectrum product.

Product type

There are all sorts of CBD products out there, from topicals to gummies.

Topical CBD products help target specific pain areas. Oils and gummies are more useful for whole-body relief.

It can be hard to find the right dose when using topical CBD products, but a good rule of thumb is to use about as much as you would with a non-CBD topical cream.

When taking an oil or gummy, always start with the lowest dose and work your way up. Edibles may take longer to kick in than other types of products, so wait a bit before you take more.

One week after starting CBD, reassess your symptoms. If you haven’t noticed much improvement, increase the dosage by about 5 mg per day. This should help you find the right dosage for you.

If you need more help figuring out CBD dosage, check out our CBD dosage guide.

The World Health Organization notes that CBD is generally safe and well-tolerated, but it can cause side effects in some people.

Some studies note potential side effects, including:

  • changes in appetite and weight
  • diarrhea
  • fatigue

It’s always a good idea to talk to your doctor before trying CBD. That’s especially important if you’re taking any medication, since CBD can interact with certain medications, including those that carry a grapefruit warning.

Studies also show that ingesting CBD products with high fat meals can dramatically increase CBD concentration in your blood. This may increase your risk of experiencing side effects.

Full-spectrum CBD contains small amounts of other cannabis compounds, like flavonoids and terpenes. It also contains a small amount of THC.

CBD isolate contains CBD only.

While the entourage effect suggests that full-spectrum products may work best, CBD isolate may still produce beneficial effects.

Always talk with your doctor before taking any CBD products.

Is CBD Legal? Hemp-derived CBD products (with less than 0.3 percent THC) are legal on the federal level, but are still illegal under some state laws. Marijuana-derived CBD products are illegal on the federal level, but are legal under some state laws. Check your state’s laws and those of anywhere you travel. Keep in mind that nonprescription CBD products are not FDA-approved, and may be inaccurately labeled.