Highlights for amitriptyline-chlordiazepoxide

  1. Chlordiazepoxide/amitriptyline is only available as a generic drug. It doesn’t have a brand-name version.
  2. This drug comes only as a tablet you take by mouth.
  3. Chlordiazepoxide/amitriptyline is a combination of two drugs in a single form. It’s used to treat people who have both depression and anxiety.

Important warnings

FDA warnings

  • This drug has black box warnings. These are the most serious warnings from the Food and Drug Administration (FDA). Black box warnings alert doctors and patients about drug effects that may be dangerous.
  • Suicidal thinking and behavior warning: This drug can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults. This is more likely to happen during the first few months of treatment with this drug. When you or your child first starts taking this drug, your doctor and family should watch closely. They should look for changes in behavior or worsening signs of depression.
  • Dangerous effects with opioid use: Using this drug with opioid drugs, such as hydrocodone, or codeine, can cause dangerous effects. Your risk is higher if you take high doses of either drug and take them for a long time. Call your doctor or 911 right away if you or someone you’re caring for has symptoms of unusual dizziness or lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. These symptoms can lead to coma and even death.

Other warnings

  • Initial worsening of depression warning: You may have worsened depression symptoms, suicidal thoughts, and changes in behavior when you first start taking this drug. You may continue to have these symptoms until the drug starts working for you. This may take up to a few weeks.
  • Withdrawal symptoms warning: You shouldn’t stop taking this drug without talking to your doctor. If you stop taking it suddenly, you may have withdrawal symptoms. These can include tremors (uncontrollable rhythmic movements in one part of your body), stomach pains, sweating, and headaches. Your risk is higher if you’ve taken this drug for a long time. If you need to stop taking this drug, your doctor will slowly lower your dosage.

What is amitriptyline-chlordiazepoxide?

Chlordiazepoxide/amitriptyline is a prescription drug. It comes as an oral tablet.

Chlordiazepoxide/amitriptyline is only available as a generic drug. It doesn’t have a brand-name version.

Chlordiazepoxide/amitriptyline is a combination drug. It contains two drugs: chlordiazepoxide and amitriptyline. It’s important to know about both drugs in the combination because each drug may affect you in a different way.

Why it's used

Chlordiazepoxide/amitriptyline is used to treat people who have both depression and anxiety.

How it works

Chlordiazepoxide belongs to a class of drugs called benzodiazepines. Amitriptyline belongs to a class of drugs called tricyclic antidepressants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Chlordiazepoxide/amitriptyline works on your central nervous system. It increases the level of certain chemicals in your brain. This improves your symptoms of depression and anxiety.

Amitriptyline-chlordiazepoxide side effects

Chlordiazepoxide/amitriptyline oral tablet may cause dizziness and drowsiness during the first few hours after you take it. It can also cause other side effects.

More common side effects

The more common side effects of chlordiazepoxide/amitriptyline can include:

  • drowsiness
  • dry mouth
  • nasal congestion
  • constipation
  • blurred vision
  • dizziness
  • bloating
  • vivid dreams
  • tremors (uncontrollable rhythmic movements in one part of your body)
  • erectile dysfunction (trouble getting or keeping an erection)
  • confusion

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Heart attack. Symptoms can include:
    • chest pain
    • shortness of breath
    • discomfort in your upper body
  • Stroke. Symptoms can include:
    • weakness in one part or side of your body
    • slurred speech
  • Worsening symptoms of depression and suicidal thoughts

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Amitriptyline-chlordiazepoxide may interact with other medications

Chlordiazepoxide/amitriptyline oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with chlordiazepoxide/amitriptyline are listed below.

Drugs you should not use with chlordiazepoxide/amitriptyline

Don’t take these drugs with chlordiazepoxide/amitriptyline. Doing so can cause dangerous effects in the body. Examples of these drugs include:

  • Opioids such as morphine, hydrocodone, or oxycodone. Taking these drugs together could increase the risk of sedation, and cause slowed or difficult breathing, coma, or death.
  • Phenelzine, tranylcypromine, and selegiline. Taking these drugs together may lead to convulsions (violent, involuntary movements) and a dangerously high fever. It may even be fatal (cause death).
  • Flecainide and propafenone. Taking these drugs together could increase your risk of irregular heart rate.
  • Sertraline, fluoxetine, and paroxetine. Taking these drugs together can increase the side effects of chlordiazepoxide/amitriptyline. These can include dizziness, confusion, and heart attack.
  • Cimetidine and quinidine. These drugs could increase the amount of the amitriptyline in your body. This could lead to dangerous side effects. These can include dizziness, confusion, and heart attack.

Interactions that increase your risk of side effects

Taking chlordiazepoxide/amitriptyline with certain medications raises your risk of side effects from chlordiazepoxide/amitriptyline. This is because the amount of chlordiazepoxide/amitriptyline in your body may be increased. Examples of these drugs include:

  • Topiramate. Increased side effects of chlordiazepoxide/amitriptyline could include drowsiness, dizziness, and constipation. If you need to take topiramate with this drug, your doctor may reduce your dosage of chlordiazepoxide/amitriptyline.
  • Opioids, such as codeine, hydrocodone, and oxycodone. Taking these drugs with chlordiazepoxide/amitriptyline puts you at serious risk of severe drowsiness, slowed breathing, coma, or death. Your doctor will only prescribe opioids with chlordiazepoxide/amitriptyline if other medications are not effective.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

Amitriptyline-chlordiazepoxide warnings

This drug comes with several warnings.

Allergy warning

Chlordiazepoxide/amitriptyline can cause a severe allergic reaction. Symptoms can include:

  • trouble breathing
  • swelling of your throat or tongue

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Alcohol interaction warning

The use of drinks that contain alcohol can increase your risk of sedation and drowsiness to dangerous levels from this drug. If you drink alcohol, talk to your doctor.

Warnings for people with certain health conditions

For people with a history of heart problems: This drug could cause heart problems. These include irregular heart rate, heart attack, and stroke. You shouldn’t take chlordiazepoxide/amitriptyline if you’ve had a recent heart attack.

For people with a history of bipolar disorder: This drug shouldn’t be used to treat bipolar disorder. Taking antidepressants, such as chlordiazepoxide/amitriptyline, can cause people with bipolar to switch from depression to a manic phase. You should use other drugs called mood stabilizers instead of antidepressants.

For people with a history of seizures: This drug may increase your risk of seizures.

For people with a history of glaucoma or increased eye pressure: This drug may make your condition worse.

For people with a thyroid condition: Thyroid drugs may increase the side effects of chlordiazepoxide/amitriptyline.

Warnings for other groups

For pregnant women: The chlordiazepoxide component of this drug has been shown to increase the risk of negative effects to the fetus. This risk is higher during the first trimester of pregnancy. Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk.

For women who are breastfeeding: Chlordiazepoxide/amitriptyline may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

If you’re over the age of 65 years, you may be at a higher risk of confusion and sedating side effects from this drug.

For children: This medication hasn’t been studied in children.

How to take amitriptyline-chlordiazepoxide

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

Dosage for depression and anxiety together

Generic: Chlordiazepoxide/amitriptyline

  • Form: oral tablet
  • Strengths:
    • 5 mg chlordiazepoxide/12.5 mg amitriptyline
    • 10 mg chlordiazepoxide/25 mg amitriptyline

Adult dosage (ages 18–64 years)

  • Typical starting dosage: 3–4 tablets (of either strength) per day taken in divided doses.
  • Dosage increases: Your doctor may slowly increase your dosage up to 6 tablets (of either strength) per day taken in divided doses.

Child dosage (ages 0–17 years)

This medication hasn’t been studied in children.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dosage or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Take as directed

Chlordiazepoxide/amitriptyline oral tablet is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all: If you don’t take this drug, your depression and anxiety may get worse. If you stop taking this drug suddenly, you may have withdrawal symptoms. These can include tremors (uncontrollable rhythmic movements in one part of your body), stomach pains, sweating, and headaches. If you need to stop taking this drug, talk to your doctor. They will slowly lower your dosage.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

  • irregular heart rate
  • very low heart rate
  • convulsions (violent, involuntary movements)
  • hallucinations (seeing or hearing something that isn’t there)
  • confusion
  • stiff muscles

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: Your symptoms of depression and anxiety should get better over time.

Important considerations for taking amitriptyline-chlordiazepoxide

Keep these considerations in mind if your doctor prescribes chlordiazepoxide/amitriptyline for you.

General

  • You can take chlordiazepoxide/amitriptyline with or without food.
  • Take this drug at the time(s) recommended by your doctor.
  • You can cut or crush the tablet.

Storage

  • Store chlordiazepoxide/amitriptyline at room temperature. Keep it between 68°F and 77°F (20°C and 25°C).
  • Keep it away from light.
  • Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t harm your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include:

  • Mental health and behavioral problems: You and your doctor should watch for any unusual changes in your behavior and mood. This drug can cause new mental health and behavior problems. It may also make problems you already have worse.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.