What is ADHD?

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder. People with ADHD have difficulty maintaining attention or have episodes of hyperactivity that interfere with their daily life.

People sometimes refer to it as ADD, but ADHD is the medically accepted term.

ADHD is common. It’s estimated that 11 percent of children have ADHD, while 4.4 percent of adults have the condition in the United States.

ADHD usually begins in childhood. It often continues through adolescence and sometimes into adulthood.

Children and adults with ADHD typically have more difficulty focusing than people who don’t have ADHD. They may also act more impulsively than their peers. This may make it difficult for them to perform well in school or work as well as the general community.

Underlying issues with the brain are likely to be the underlying cause of ADHD. No one knows exactly what causes a person to have ADHD, but some researchers have looked at a neurotransmitter called dopamine as a possible contributor to ADHD.

Dopamine allows us to regulate emotional responses and take action to achieve specific rewards. It’s responsible for feelings of pleasure and reward.

Scientists have observed that levels of dopamine are different in people with ADHD than in those without ADHD.

Some researchers believe this difference is because neurons in the brain and nervous systems of people with unmedicated ADHD have lower concentrations of proteins called dopamine transporters. The concentration of these proteins is known as dopamine transporter density (DTD).

Lower levels of DTD may be a risk factor for ADHD. Just because someone has low levels of DTD, however, doesn’t mean they have ADHD. Doctors will typically use a holistic review to make a formal diagnosis.

One of the first studies that looked at DTD in humans was published in 1999. The researchers noted a 70 percent increase in DTD in 6 adults with ADHD compared to study participants who didn’t have ADHD. This suggests that increased DTD may be a useful screening tool for ADHD.

Since this early study, research has continued to show an association between dopamine transporters and ADHD.

A 2015 study looked at research showing that the dopamine transporter gene, DAT1, may influence ADHD-like traits. They surveyed 1,289 healthy adults.

The survey asked about impulsivity, inattention, and mood instability, which are the 3 factors that define ADHD. But the study didn’t show any association with ADHD symptoms and gene abnormalities other than mood instability.

DTD and genes such as DAT1 aren’t definite indicators of ADHD. Most clinical studies have included only a small number of people. More studies are needed before firmer conclusions can be drawn.

Additionally, some researchers argue that other factors contribute more to ADHD than dopamine levels and DTD.

One study in 2013 found that that the amount of gray matter in the brain might contribute to ADHD more than levels of dopamine. Other research from 2006 showed that dopamine transporters were lower in parts of the left brain in participants that had ADHD.

With these somewhat conflicting findings, it’s hard to say if levels of DTD always indicate ADHD. Nonetheless, the research showing an association between ADHD and lower levels of dopamine, as well as lower levels of DTD, suggests that dopamine could be a possible treatment for ADHD.

Medications that increase dopamine

Many medications for treating ADHD work by increasing dopamine and stimulating focus. These medications are typically stimulants. They include amphetamines such as:

These medications increase dopamine levels in the brain by targeting dopamine transporters and increasing dopamine levels.

Some people believe that taking a high dosage of these medications will lead to greater focus and attention. This is not true. If your dopamine levels are too high, this can make it difficult for you to focus.

Other treatments

In 2003, the FDA approved the use of nonstimulant drugs to treat ADHD.

Additionally, doctors recommend behavior therapy for both the person who has ADHD as well as their loved ones. Behavior therapy typically involves going to a board-certified therapist for counseling.

Scientists aren’t certain what causes ADHD. Dopamine and its transporters are just two potential factors.

Researchers have observed that ADHD tends to be more common in families. This is explained in part because many different genes may contribute to the incidence of ADHD.

Several lifestyle and behavioral factors may also contribute to ADHD. They include:

  • exposure to toxic substances, such as lead, during infancy and childbirth
  • maternal smoking or drinking during pregnancy
  • a low birth weight
  • complications during childbirth

The association between ADHD, dopamine, and DTD is promising. Several effective medications used to treat the symptoms of ADHD work by increasing the impact of dopamine on the body. Researchers are also still investigating this association.

That being said, dopamine and DTD aren’t the only underlying causes of ADHD. Researchers are investigating new possible explanations such as the amount of gray matter in the brain.

If you have ADHD or suspect you do, talk to your doctor. They can give you a proper diagnosis and you can start on a plan that may include drugs and natural methods that increase dopamine.

You can also do the following to increase your dopamine levels:

  • Try something new.
  • Make a list of small tasks and complete them.
  • Listen to music you enjoy.
  • Exercise regularly.
  • Meditate and do yoga.