- A new study shows that inflammation may increase the risk of developing Alzheimer’s disease and dementia.
- Biomarkers for chronic inflammation were linked to the higher risk.
- Researchers and health experts say there are dietary and physical activity efforts that can have a positive effect on lowering inflammation.
The medical community has increasingly identified the role of inflammation in the development of Alzheimer’s disease and dementia — now a new study from the UK further establishes that link.
Despite the prevalence of dementia among the elderly and its burden on the healthcare system (costing hundreds of billions of dollars each year), researchers have
The greatest known risk factor for Alzheimer’s disease is aging, but there is also a cluster of other risk factors identified as potential causes, including genetic predisposition, inflammation, cardiovascular health, and brain chemistry (
Specifically, researchers looked at certain blood biomarkers indicative of inflammation and how these correlated with various cognitive tasks. They found a small, but statistically significant, association between higher levels of these biomarkers, worse cognitive performance, and higher risk of dementia later in life.
“Elevated levels of blood inflammatory markers are often found in elderly individuals and this condition is termed ‘inflammageing.’ Inflammageing carries a high susceptibility to chronic diseases and premature death. We found associations between elevated systemic inflammation biomarker levels, concurrent and later cognitive performance, and future dementia risk,” Dr. Krisztina Mekli, lead author of the study and a genetic researcher at the University of Manchester, told Healthline.
For the UKB, more than a half-million participants willingly consented to have their health information used for scientific and research purposes. The cohort included both men and women, recruited between 2006-2010, and were between 40-69 years old at the time. Participants in the UKB were also included as part of a longitudinal study that followed them over the course of years to capture any subsequent health events.
Mekli and her team sifted through massive amounts of data to look at one specific question: does the presence of certain inflammatory biomarkers affect cognitive ability and dementia risk.
They found that the answer was yes.
Dr. Paul Newhouse, Director of the Center for Cognitive Medicine in the Department of Psychiatry at Vanderbilt University Medical Center, who was not affiliated with the study, told Healthline, “What this work suggests is that even in a very large study, they can show a small but measurable effect of chronic low-level inflammatory markers in the body.”
Members of the UKB cohort were asked to take part in a series of cognitive tests, designed to test different forms of brain function: things like memory and reaction time.
To measure different aspects of cognitive functioning, researchers employed a series of different kinds of tests. For reaction time, individuals were told to press a button as soon as they saw two matching cards appear on a screen. For memory, they were asked to remember the location of matching pairs of cards; they were also given strings of numbers, beginning with two digits and progressing up to twelve digits, and asked to input those strings of numbers. Logic and reasoning questions were employed to test “fluid intelligence.”
“Literature indicates that tests of specific domains, such as episodic memory, executive function, verbal fluency, and processing speed are predictors of dementia. The cognitive tests in UKB were designed to be brief and to tap into cognitive domains that are sensitive to ageing and/or pathological processes,” Dr. Mekli told Healthline.
With the exception of the “pair matching” exercise, individuals with higher levels of inflammation biomarkers exhibited “increasingly worse” performance in each of the cognitive exercises. Even more startling, those with the highest levels of biomarkers were found to have a 35% increased risk of dementia diagnosis compared to those with the lowest levels of biomarkers.
Not exactly. Inflammation is actually a good thing;
There’s no simple cure for inflammation and, by extension, dementia either, but both Mekli and Newhouse suggest that lifestyle changes like eating healthier and exercising more often are a good place to start.
“There is data emerging that certain dietary and physical activity efforts can have a positive effect on inflammation,” said Newhouse, “We do believe that regular physical exercise actually can tamp down inflammation in a systemic way.”
A new study finds that people with biomarkers that signal higher levels of inflammation had a higher risk of dementia.
Exercise and anti-inflammatory dietary patterns could help reduce the risk of cognitive decline and dementia.