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Generic Name:

vedolizumab, Injectable solution

Entyvio

Entyvio

Generic Name: vedolizumab, Injectable solution

All Brands

  • Entyvio
SECTION 1 of 4

Highlights for Entyvio

Injectable solution
1

Entyvio is used to treat Crohn’s disease and ulcerative colitis in adults. It helps reduce inflammation (swelling and irritation) in the gastrointestinal (GI) tract.

2

Entyvio comes as an intravenous (IV) infusion. This means it’s injected into your vein. It’s only given by a healthcare provider in a healthcare facility.

3

Entyvio is a brand-name drug. It’s not available as a generic drug.

4

The more common side effects of taking Entyvio include headache, joint pain, nausea, fever, and upper respiratory tract infection.

5

Before starting Entyvio, you should make sure all of your vaccinations are up to date.

IMPORTANT INFORMATION
  • Progressive multifocal leukoencephalopathy

    Progressive multifocal leukoencephalopathy (PML) See Details

Progressive multifocal leukoencephalopathy (PML)

PML has been observed in patients taking medications similar to this drug. Symptoms can include confusion or problems thinking, loss of balance, or changes in the way you walk or talk. They can also include weakness on one side of the body, or blurred vision or loss of vision. If you have any of these symptoms, stop taking this drug and call your doctor right away.

What is Entyvio?

This drug is a prescription medication. It comes as an intravenous (IV) drug. This means it’s injected into your vein. This medication is only given by a healthcare provider in a healthcare facility.

This drug is available as a brand-name drug called Entyvio. It’s not available as a generic drug.

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

Why it's used

This drug is used to treat the symptoms of both ulcerative colitis (UC) and Crohn’s disease. It’s used to treat moderate-to-severe, active disease. This drug is used when certain other medications have not worked well enough.

More Details

How it works

This drug belongs to a class of drugs called integrin receptor antagonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. 

More Details

Why it's used

This drug is used to treat the symptoms of both ulcerative colitis (UC) and Crohn’s disease. It’s used to treat moderate-to-severe, active disease. This drug is used when certain other medications have not worked well enough. It may also be used when a person doesn’t react well to these other medications. 

For the treatment of UC, this drug may help:

  • Bring your UC under control (cause remission). It may also help keep it under control (maintain remission).
  • Reduce your need to use corticosteroid medications, if you’re taking them to treat your UC. It may even allow you to stop taking these medications.
  • Improve the way the lining of your large intestine looks to your healthcare provider during exams such as a colonoscopy. 

For the treatment of Crohn’s disease, this drug may help:

  • Bring your Crohn’s disease under control (cause remission). It may also help keep it under control (maintain remission).
  • Reduce your need to use corticosteroid medications, if you’re taking them to treat your Crohn’s disease. It may even allow you to stop taking these medications.

How it's used

This drug belongs to a class of drugs called integrin receptor antagonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. 

This drug works on your immune system. It helps reduce inflammation (swelling and irritation) in your gastrointestinal (GI) tract that’s caused by Crohn’s disease or ulcerative colitis. 

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SECTION 2 of 4

Entyvio Side Effects

Injectable solution

More Common Side Effects

The more common side effects that can occur with use of Entyvio include:

  • common cold

  • back pain

  • headache

  • joint pain

  • upset stomach

  • nose irritation

  • sore throat

  • pain in the arms or legs

  • feeling tired or weak

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Serious allergic reactions. Symptoms can include:

    • rash
    • itching
    • swelling of your lips, tongue, throat, or face
    • shortness of breath or trouble breathing
    • wheezing
    • dizziness
    • feeling hot
    • heart palpitations (very rapid or irregular heartbeat)
  • Infections. Symptoms can include:

    • fever
    • chills
    • muscle aches
    • cough
    • shortness of breath
    • runny nose
    • sore throat
    • red or painful skin sores on your body
    • tiredness
    • pain during urination
  • Progressive multifocal leukoencephalopathy (PML). Symptoms can include:

    • confusion or trouble thinking
    • loss of balance
    • changes in the way you walk or talk
    • decreased strength or weakness on one side of your body
    • blurred vision or loss of vision
  • Liver problems. Symptoms can include:

    • tiredness
    • loss of appetite
    • pain on the right side of your abdomen (stomach area)
    • dark-colored urine
    • yellowing of your skin and whites of your eyes
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug doesn’t cause drowsiness. But it can cause a serious allergic reaction. This can occur shortly after you receive your infusion. Your doctor will monitor you for symptoms of an allergic reaction while you are receiving this medication.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

Entyvio May Interact with Other Medications

Injectable solution

Entyvio can interact with other medications, herbs, or vitamins you might be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. Your healthcare provider will look out for interactions with your current medications. Always be sure to tell your doctor about all medications, herbs, or vitamins you’re taking.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
infections
People with infections

Treatment with this drug is not recommended if you have a severe infection. Before starting to take this drug, tell your doctor if you have any symptoms of an infection. These can include fever, chills, sore throat, runny nose, body aches, shortness of breath, or tiredness. You shouldn’t start taking this drug until any infection has cleared.

Pregnant women
Pregnant women

This drug is a category B pregnancy drug. That means two things:

  1. Research in animals has not shown a risk to the fetus when the mother takes the drug.
  2. There aren’t enough studies done in humans to show if the drug poses a risk to the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. Animal studies do not always predict the way humans would respond. Therefore, this drug should only be used in pregnancy if clearly needed. 

breast-feeding
Women who are breast-feeding

This drug may pass into breast milk and cause side effects in a child who is breast-fed.

Talk to your doctor if you breast-feed your child. You may need to decide whether to stop breast-feeding or stop taking this medication.

seniors
For seniors

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

children
For children

It hasn’t been established that this drug is safe or effective for use in children younger than 18 years.

call the doctor
When to call the doctor

Call your doctor if:

  • Your symptoms get worse. These can include diarrhea, constipation, rectal bleeding, an urgent need to move your bowels, or abdominal cramps.
  • You become pregnant while taking this drug.
allergies
Allergies

This drug can cause a severe allergic reaction. Symptoms can include: 

  • rash
  • itching
  • swelling of your lips, tongue, throat, or face
  • shortness of breath or trouble breathing
  • wheezing
  • dizziness
  • feeling hot
  • heart palpitations (a fast, irregular heartbeat) 

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room. 

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

SECTION 4 of 4

How to Take Entyvio (Dosage)

Injectable solution

Your doctor will determine a dosage that’s right for you based on your individual needs. Your general health may affect your dosage. Tell your doctor about all health conditions you have before your healthcare provider administers the drug to you.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all

Your symptoms of UC or Crohn’s disease may get worse. These can include diarrhea, constipation, rectal bleeding, an urgent need to move your bowels, or abdominal cramps.

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

What to do if you miss a dose

Call your doctor right away to reschedule your appointment to receive this drug.

How to tell if the drug is working

Your symptoms of UC or Crohn’s disease should improve. 

This drug is used for long-term treatment. 

Take this drug at the times recommended by your doctor

After your first dose of this drug, you’ll receive a second dose 2 weeks later. Then you’ll receive a third dose 6 weeks after your second dose.

After these first three doses, you’ll receive this drug every 8 weeks. Your doctor will tell you how often to schedule your appointments to receive your infusions.

How long does it take?

This drug is given as an infusion into your vein (intravenous). Each infusion takes about 30 minutes. 

Travel

After the initial three doses, this drug is given every 8 weeks. If you plan to travel, talk with your doctor about your travel plans and whether they will affect your dosing schedule.

Clinical monitoring

Your doctor will monitor you during treatment with this drug.

  • Your doctor will check your signs and symptoms to see if this drug is working well to treat your disease.
  • Your doctor will do blood tests to monitor your liver function. This is to make sure that your medication isn’t harming your liver. 

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.


Show Sources

  • Taketa Pharmaceuticals America, Inc. (2014). Entyvio – vedolizumab [package insert]. Deerfield, IL.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on November 11, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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