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Generic Name:

lansoprazole, Oral capsule, sprinkles

All Brands

  • Prevacid
SECTION 1 of 4

Highlights for lansoprazole

Oral capsule, sprinkles
1

Lansoprazole is used to reduce the amount of acid in your stomach. It can be used to treat gastric ulcers (stomach ulcers), duodenal ulcers, erosive esophagitis, and heartburn due to gastroesophageal reflux disease (GERD). This drug is used to prevent and treat stomach ulcers due to nonsteroidal anti-inflammatory drugs (NSAIDs). This medication is also used to treat conditions in which your stomach makes too much acid, such as Zollinger-Ellison syndrome. It can also be used with an antibiotic to treat a stomach infection caused by Helicobacter pylori.

2

This drug comes in the form of a capsule and a disintegrating tablet you take by mouth.

3

Lansoprazole is available as the brand-name drugs Prevacid and Prevacid SoluTab. It’s also available as a generic drug.

4

The more common side effects of this drug include diarrhea, stomach pain, nausea, constipation, and headache.

5

In some cases, lansoprazole can cause serious side effects. These include severe diarrhea, kidney damage, vitamin B-12 deficiency, magnesium deficiency, and bone breaks.

IMPORTANT INFORMATION

Bone fractures

People who take several doses of this drug per day for 1 year or longer may have an increased risk of bone fractures. These breaks may be more likely to happen in your hip, wrist, or spine. Talk to your doctor about your risk of bone fractures. You should take this drug exactly as prescribed by your doctor. Your doctor should prescribe the lowest dose possible for your treatment for the shortest amount of time.

Severe diarrhea

This drug may increase your risk of severe diarrhea. This may be caused by an infection in your intestine due to Clostridium difficile. Call your doctor right away if you have watery diarrhea, stomach pain, and a fever that won’t go away.

Kidney damage

This drug may cause kidney damage. Call your doctor if you have flank pain (pain in your side and back) or changes in urination during treatment.

CLE and SLE

Lansoprazole can cause cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). CLE and SLE are autoimmune diseases. Symptoms of CLE can range from a rash on the skin and nose, to a raised, scaly, red or purple rash on certain parts of the body. Symptoms of SLE can include fever, tiredness, weight loss, blood clots, heartburn, and stomach pain. If you have any of these symptoms, call your doctor.

What is lansoprazole?

Lansoprazole is a prescription drug. It’s available as a delayed-release oral capsule and a delayed-release orally disintegrating tablet. A delayed-release drug doesn’t release the medication until it passes through your stomach. This prevents the drug from being inactivated by your stomach.

Lansoprazole is available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version.

Lansoprazole may be used as part of a combination therapy. This means you may need to take it with other medications.

Why it's used

Lansoprazole is used to reduce the amount of acid in your stomach.

See Details

How it works

Lansoprazole belongs to a class of drugs called proton pump inhibitors.

See Details

Why it's used

Lansoprazole is used to reduce the amount of acid in your stomach.

It can be used to treat gastric ulcers (stomach ulcers) or duodenal ulcers, heartburn due to gastroesophageal reflux disease, and erosive esophagitis. Erosive esophagitis is a condition with inflammation and ulcers in the esophagus.

This drug is also used to prevent and treat stomach ulcers due to nonsteroidal anti-inflammatory drugs.

This medication is used to treat hypersecretory conditions, or conditions where your stomach makes too much acid, such as Zollinger-Ellison syndrome. It can also be used with an antibiotic to treat a stomach infection caused by Helicobacter pylori.

How it works

Lansoprazole belongs to a class of drugs called proton pump inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Lansoprazole works by decreasing the amount of acid produced in your stomach. It does this by blocking the proton pump in the cells of your stomach. The proton pump works in the final step of acid production. When the proton pump is blocked, your stomach makes less acid. This should decrease your symptoms.

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SECTION 2 of 4

lansoprazole Side Effects

Oral capsule, sprinkles

More common side effects

The more common side effects of lansoprazole can include:

  • diarrhea

  • stomach pain

  • nausea

  • constipation

  • headache

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following: 

  • Vitamin B-12 deficiency. Using this drug every day for longer than 3 years can make it harder for your body to absorb vitamin B-12. Symptoms can include:

    • nervousness
    • neuritis (inflammation of a nerve)
    • numbness and tingling in your hands and feet
    • poor muscular coordination
    • changes in menstruation
  • Low magnesium levels in your body. Using this drug for 3 months or longer can decrease your magnesium levels. Symptoms can include:

    • seizures
    • dizziness
    • abnormal or fast heart rate
    • jitters
    • tremors (jerking movements or shaking)
    • muscle weakness
    • spasms in your hands and feet
    • cramps or muscle aches
    • spasms of your voice box
  • Serious allergic reactions. Symptoms can include:

    • rash
    • swelling of your face
    • throat tightness
    • trouble breathing
  • Diarrhea from Clostridium difficile infection. Symptoms can include:

    • stomach pain
    • watery diarrhea
    • fever
  • Bone fractures

  • Kidney damage. Symptoms can include:

    • flank pain (pain in your side and back)
    • changes in urination
  • Cutaneous lupus erythematosus (CLE). Symptoms can include:

    • rash on the skin and nose
    • raised, red, scaly, red or purple rash on your body
  • Systemic lupus erythematosus (SLE). Symptoms can include:

    • fever
    • tiredness
    • weight loss
    • blood clots
    • heartburn
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Lansoprazole doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

lansoprazole May Interact with Other Medications

Oral capsule, sprinkles

Lansoprazole can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Medications that might interact with this drug

Drugs you should not use with lansoprazole

Do not take these drugs with lansoprazole. Doing so can cause dangerous effects in the body. Examples of these drugs include:

  • Human immunodeficiency virus (HIV) drugs, such as atazanavir. Lansoprazole may decrease the levels of atazanavir in your body. This means that it won’t work as well to treat HIV. You may even develop HIV resistance. Resistance means that the HIV virus will no longer respond to treatment with this drug.

Interactions that increase the risk of side effects

Side effects from other drugs: Taking lansoprazole with certain medications raises your risk of side effects from these drugs. Examples of these drugs include:

  • Warfarin. You may have more bleeding. If you need to take both of these drugs, your doctor will monitor your lab results (such as INR) closely. They may also adjust your warfarin dose.
  • Digoxin. Lansoprazole can increase the levels of digoxin in your body. This can raise your risk of side effects. Your doctor may check the levels of digoxin in your body and adjust your digoxin dose if needed.
  • Methotrexate. Lansoprazole can increase the levels of methotrexate in your body. This puts you at risk of more side effects. If you’re taking a high dose of methotrexate, your doctor may have you stop taking lansoprazole temporarily.
  • Tacrolimus. Lansoprazole can increase the levels of tacrolimus in your body. This puts you at increased risk of side effects. Your doctor may check the levels of tacrolimus in your body and adjust your tacrolimus dose if needed.

Interactions that can make your drugs less effective

When lansoprazole is less effective: When lansoprazole is used with certain drugs, it may not work as well to treat your condition. This is because the amount of lansoprazole in your body may be decreased. Examples of these drugs include:

  • Sucralfate. Lansoprazole may not work as well when taken with sucralfate. You should take lansoprazole at least 30 minutes before you take sucralfate to avoid interactions.

When other drugs are less effective: When certain drugs are used with lansoprazole, they may not work as well. This is because the amount of these drugs in your body may be decreased. Examples of these drugs include:

  • Ampicillin. Lansoprazole can prevent your body from absorbing ampicillin well. Ampicillin may not work as well to treat your infection.
  • Ketoconazole. Lansoprazole can prevent your body from absorbing ketoconazole well. Ketoconazole may not work as well to treat your infection.
  • Mycophenolate mofetil (MMF). Lansoprazole can prevent your body from absorbing MMF properly. MMF may not work as well. It isn’t known how this interaction may affect your risk of organ rejection. If you take MMF, ask your doctor whether lansoprazole is safe for you.
  • Iron salts. Lansoprazole can prevent your body from absorbing drugs that contain iron well.
  • Erlotinib. Lansoprazole can prevent your body from absorbing erlotinib well. Erlotinib may not work as well to treat your cancer.
  • Theophylline. Lansoprazole may decrease the levels of theophylline in your body. This means that theophylline may not work as well to treat your asthma or chronic obstructive pulmonary disease (COPD). Your doctor may monitor the levels of theophylline in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Lansoprazole warnings
liver problem warning
People with liver problems

If you have liver problems or a history of liver disease, you may not be able to clear this drug from your body well. If you have severe liver disease, your doctor may reduce your dose of lansoprazole.

vitamin deficiency warning
People with a vitamin B-12 deficiency

Taking this drug for longer than 3 years can decrease the vitamin B-12 levels in your blood. This drug can further decrease your low vitamin B-12 levels. Your doctor may give you vitamin B-12 injections and monitor your vitamin B-12 levels.

osteoporosis warning
People with osteoporosis

People who take multiple doses of this drug per day for 1 year or longer may have an increased risk of fractures. If you already have osteoporosis, your risk is even higher.

low magnesium warning
People with low magnesium levels

Taking this drug for 3 months or longer can decrease the magnesium levels in your blood. This drug can further decrease your magnesium levels if they are already low. Your doctor may give you magnesium supplements and monitor your magnesium levels.

phenylketonuria warning
People with phenylketonuria (PKU)

Lansoprazole orally disintegrating tablets (Prevacid SoluTab) contain aspartame. There are 2.5 mg of phenylalanine in each 15-mg tablet and 5.1 mg of phenylalanine in each 30-mg tablet.

pregnancy warning
Pregnant women

Lansoprazole is a category B pregnancy drug. That means two things:

  1. Research in animals has not shown a risk to the fetus when the mother takes the drug.
  2. There aren’t enough studies done in humans to show if the drug poses a risk to the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. Animal studies do not always predict the way humans would respond. Therefore, this drug should only be used in pregnancy if clearly needed.

breast feeding warning
Women who are breast-feeding

It isn’t known if lansoprazole passes into breast milk. If it does, it may cause side effects in a child who is breastfed.

Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

childrens warning
For children

This drug has not been shown to be safe or effective for treating GERD or erosive esophagitis in children younger than 1 year. It shouldn’t be used in children younger than 1 year for these conditions.

This drug hasn’t been studied in children for the following conditions:

  • duodenal ulcers
  • gastric ulcers
  • hypersecretory conditions
  • Helicobacter pylori infections

This drug shouldn’t be used in people younger than 18 years for these conditions.

call the doctor
When to call the doctor

Call your doctor if your symptoms don’t get better while taking this drug. It should only take a few hours for this drug to start working.

allergy warning
Allergies

Lansoprazole can cause a severe allergic reaction. Symptoms can include:

  • rash
  • face swelling
  • throat tightness
  • trouble breathing

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

SECTION 4 of 4

How to Take lansoprazole (Dosage)

Oral capsule, sprinkles

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Duodenal ulcers

Brand: Prevacid

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg

Brand: Prevacid SoluTab

Form: delayed-release orally disintegrating tablet
Strengths: 15 mg, 30 mg

Generic: Lansoprazole

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg
Adult dosage (ages 18 and older)
  • Typical dose: 15 mg taken once per day for 4 weeks. Your doctor may have you take this drug for a longer amount of time for continued healing of your ulcer.
Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years.

Gastric ulcers (stomach ulcers)

Brand: Prevacid

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg

Brand: Prevacid SoluTab

Form: delayed-release orally disintegrating tablet
Strengths: 15 mg, 30 mg

Generic: Lansoprazole

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg
Adult dosage (ages 18 and older)
  • Typical dose: 30 mg taken once per day for up to 8 weeks
Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years.

Gastric ulcers from NSAIDs

Brand: Prevacid

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg

Brand: Prevacid SoluTab

Form: delayed-release orally disintegrating tablet
Strengths: 15 mg, 30 mg

Generic: Lansoprazole

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg
Adult dosage (ages 18 and older)
  • For short-term treatment: 30 mg taken once per day for 8 weeks
  • For prevention: 15 mg taken once per day for up to 12 weeks
Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years.

Erosive esophagitis

Brand: Prevacid

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg

Brand: Prevacid SoluTab

Form: delayed-release orally disintegrating tablet
Strengths: 15 mg, 30 mg

Generic: Lansoprazole

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg
Adult dosage (ages 18 and older)
  • For short-term treatment: 30 mg taken once per day for up to 8 weeks
  • For maintenance: 15 mg taken once per day
Child dosage (ages 0–11 months)

This drug hasn’t been studied in children younger than 1 year.

Child dosage (ages 1-11 years)
  • Children who weigh 30 kg (66 lbs.) or less: 15 mg taken once per day for up to 12 weeks
  • Children who weigh more than 30 kg (66 lbs.): 30 mg taken once per day for up to 12 weeks
Child dosage (ages 12-17 years)

30 mg taken once per day for up to 8 weeks

Gastroesophageal reflux disease (GERD)

Brand: Prevacid

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg

Brand: Prevacid SoluTab

Form: delayed-release orally disintegrating tablet
Strengths: 15 mg, 30 mg

Generic: Lansoprazole

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg
Adult dosage (ages 18 and older)
  • Typical dose: 15 mg taken once per day for up to 8 weeks
Child dosage (ages 0–11 months)

This drug hasn’t been studied in children younger than 1 year.

Child dosage (ages 1-11 years)
  • Children who weigh 30 kg (66 lbs.) or less: 15 mg taken once per day for up to 12 weeks
  • Children who weigh more than 30 kg (66 lbs.): 30 mg taken once per day for up to 12 weeks
Child dosage (ages 12-17 years)

15 mg taken once per day for up to 8 weeks

Hypersecretory conditions

Brand: Prevacid

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg

Brand: Prevacid SoluTab

Form: delayed-release orally disintegrating tablet
Strengths: 15 mg, 30 mg

Generic: Lansoprazole

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg
Adult dosage (ages 18 and older)
  • Typical starting dose: 60 mg taken once per day
  • Dose increases: Your doctor will adjust your dose as needed. If you’re taking more than 120 mg per day, your doctor will have you take it in divided doses.
Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years.

Helicobacter pylori stomach infections

Brand: Prevacid

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg

Brand: Prevacid SoluTab

Form: delayed-release orally disintegrating tablet
Strengths: 15 mg, 30 mg

Generic: Lansoprazole

Form: delayed-release oral capsule
Strengths: 15 mg, 30 mg
Adult dosage (ages 18 and older)
  • Triple therapy dose: If you’re taking this drug with amoxicillin and clarithromycin, take 30 mg of this drug twice per day (every 12 hours) for 10 or 14 days.
  • Dual therapy dose: If you’re taking this drug with only amoxicillin, take 30 mg of this drug three times per day (every 8 hours) for 14 days.
Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Lansoprazole comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all

Your symptoms may not improve. Your condition may get worse.

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much

You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

  • diarrhea
  • stomach pain
  • nausea
  • constipation
  • headache

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room right away.

What to do if you miss a dose

Take your dose as soon as you remember. If you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working

Your symptoms should improve.

Lansoprazole is used for short-term treatment of:

  • duodenal ulcers
  • gastric ulcers
  • ulcers caused by nonsteroidal anti-inflammatory drugs
  • gastroesophageal reflux disease
  • erosive esophagitis
  • Helicobacter pylori infections

Lansoprazole is used for long-term treatment of:

  • hypersecretory conditions (Zollinger-Ellison syndrome)
  • ulcer and erosive esophagitis maintenance
Important considerations for taking lansaprazole
Take lansoprazole about 30 minutes before eating a meal
Take lansoprazole about 30 minutes before eating a meal
timing
Take this drug at the time(s) recommended by your doctor
Do not cut or crush this medication
Do not cut or crush this medication
See Details
storage
Store this drug carefully
See Details
medication is refillable
A prescription for this medication is refillable
See Details
Travel
Travel
See Details
Self-management
Self-management
See Details
Clinical monitoring
Clinical monitoring
See Details
not usually stocked
Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead
prior authorization
Insurance
See Details

Do not cut or crush this medication

Delayed-release oral capsules: Don’t crush or chew the capsule. You can open the contents of the capsule and sprinkle it onto 1 tablespoon of applesauce, cottage cheese, yogurt, or strained pears. Swallow the mixture right away. You can also mix the contents of the capsule with ¼ cup of apple juice, orange juice, or tomato juice. Drink the mixture right away.

Delayed-release orally disintegrating tablets: Don’t break, cut, or chew the tablet.

Store this drug carefully

  • Store lansoprazole at room temperature. Keep it between 68°F and 77°F (20°C and 25°C).
  • Don’t store this medication in moist or damp areas, such as bathrooms.

A prescription for this medication is refillable

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

To take the orally disintegrating tablets:

  • Put the tablet on your tongue and let it dissolve. It should dissolve in less than 1 minute. You can take it with or without water.
  • Swallow after the tablet dissolves.

Clinical monitoring

You and your doctor should monitor certain health issues. This can help make sure that you stay safe while you take this drug. These issues include:

  • Liver function. Your doctor may do blood tests to check how well your liver is working. If your liver isn’t working well, your doctor may lower your dose of this drug.
  • Magnesium levels in your blood. This drug may decrease the level of magnesium in your blood. Your doctor may check your magnesium levels and give you supplements if needed.
  • Vitamin B-12. This drug may decrease the levels of vitamin B-12 in your body. Your doctor may check your vitamin B-12 levels and give you vitamin B-12 injections if needed.
  • Diarrhea. If you have severe diarrhea that’s not going away, your doctor may check you for a Clostridium difficile infection.
  • Bone strength. Your doctor may do tests to see if you have osteoporosis. This drug may increase your risk of bone fractures if you have osteoporosis.

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.


Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on January 5, 2017

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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