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Generic Name:

dasabuvir-ombitasvir-paritaprevir-ritonavir, Oral tablet

Viekira,Viekira XR

Viekira Pak

Generic Name: dasabuvir-ombitasvir-paritaprevir-ritonavir, Oral tablet

All Brands

  • Viekira
  • Viekira XR
SECTION 1 of 4

Highlights for Viekira Pak

Oral tablet
1

Ombitasvir/paritaprevir/ritonavir/dasabuvir is a combination of drugs that treat hepatitis C virus (HCV) infection. It’s used to treat people with HCV who have a certain type of liver damage.

2

This medication is available under the brand name Viekira Pak. A generic version is not available.

3

The Viekira Pak package contains two tablets. The pink tablet contains the drugs ombitasvir, paritaprevir, and ritonavir. The beige tablet contains the medicine dasabuvir.

4

Take Viekira Pak exactly as prescribed. If you don’t, your HCV may become resistant to one or more of the drugs. When the virus becomes resistant to the drug, the drug no longer works.

5

It isn’t known if this medication reduces your risk of infecting other people with HCV. Talk with your doctor about ways to prevent spreading HCV.

IMPORTANT INFORMATION

FDA warning

Hepatitis B reactivation risk. If you also have hepatitis B and are not receiving treatment for it, taking this drug can cause a reactivation of the hepatitis B virus. In some cases, this can lead to liver failure and death. Before taking this drug, make sure your doctor knows about your hepatitis B and is treating it appropriately.

Liver damage

This medication may cause damage to your liver. Contact your doctor right away if you have the following symptoms, which could indicate liver damage:

  • general tiredness
  • weakness
  • loss of appetite
  • nausea and vomiting
  • yellowing of your skin or the whites of your eyes
  • color changes in your stools

Your doctor will do blood tests to check your liver function, especially during the first 4 weeks of treatment.

The risk of liver damage may be greater in women who are taking certain oral contraceptives. If you take an oral contraceptive, talk with your doctor about whether you should stop taking it.

Ritonavir drug resistance

Ritonavir, one of the drugs in this medication, is also used as part of a combination therapy for human immunodeficiency virus (HIV) infection. If you have both HIV and HCV infections, the ritonavir in this drug may lead to HIV resistance to ritonavir. If this happens, ritonavir can’t be used to treat your HIV. If you have both HIV and HCV infections and take Viekira Pak, make sure your doctor knows this so they can make sure you have the right drugs to treat your HIV infection and avoid resistance.

What is Viekira Pak?

This drug is a prescription medication. It’s available as a combination of oral tablets.

This is a combination of multiple drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique traits.

This drug may be used as part of a combination therapy. That means you may need to take it with other drugs.

Why it's used

This drug is a combination of drugs that treat hepatitis C virus (HCV) infection.

How it works

The drugs in this combination treatment work to stop the virus from growing.

More Details

How it works

The drugs in this combination treatment work to stop the virus from growing. One of the drugs boosts the effects of the other drugs.

Ombitasvir, paritaprevir, and dasabuvir (three drugs in this treatment) are antiviral drugs that act on HCV directly and stop the virus from growing in your body.

Ritonavir (the fourth drug in this treatment) doesn’t treat the HVC directly. It boosts the effect of the other three drugs (ombitasvir, paritaprevir, and dasabuvir) by making them stay in your body longer.

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SECTION 2 of 4

Viekira Pak Side Effects

Oral tablet

More Common Side Effects

The more common side effects that occur with Viekira Pak include:

  • nausea

  • itching

  • trouble sleeping

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • liver damage. Symptoms may include:

    • extreme tiredness
    • weakness
    • loss of appetite
    • nausea and vomiting
    • yellowing of your skin or the whites of your eyes
    • color changes in your stools
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug doesn’t cause drowsiness.

Mild side effects may disappear within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

Viekira Pak May Interact with Other Medications

Oral tablet

Viekira Pak can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol interaction

Alcohol can harm your liver. Drinking alcohol while taking this drug could make your liver damage worse.

Medications that might interact with this drug

Enlarged prostate drugs
  • alfuzosin

Anti-seizure drugs
  • carbamazepine
  • phenytoin
  • phenobarbital

These medications can decrease levels of Viekira Pak drugs in your body. This will make Viekira Pak less effective in treating your hepatitis C virus (HCV) infection.

Antibiotic
  • rifampin

This medication can decrease levels of Viekira Pak drugs in your body. This will make Viekira Pak less effective in treating your HCV infection.

Herbal product
  • St. John’s wort

This medication can decrease levels of Viekira Pak drugs in your body. This will make Viekira Pak less effective in treating your HCV infection.

Cholesterol drugs
  • gemfibrozil

Taking this drug with Viekira Pak can greatly increase the level of dasabuvir, one of the drugs in Viekira Pak, in your body. This can increase your risk for irregular heart rhythm.

  • lovastatin
  • simvastatin
  • atorvastatin

Taking Viekira Pak with these drugs can increase the levels of these cholesterol drugs in your body. This raises your risk of muscle pain or serious muscle breakdown. Do not take these drugs with Viekira Pak.

  • rosuvastatin
  • pravastatin

Taking Viekira Pak with these drugs can increase the levels of these two cholesterol drugs in your body. This can put you at increased risk of side effects from these two drugs.

Ergot-derived medications
  • ergotamine
  • dihydroergotamine
  • ergonovine
  • methylergonovine

The levels of these medications can increase and cause ergot toxicity when you take them with Viekira Pak. This can include a narrowing of your blood vessels, which can lead to tissue damage in your body.

Birth control drugs
  • drugs that contain ethinyl estradiol

Taking these drugs with Viekira Pak may damage your liver. Signs and symptoms of liver damage include:

  • general tiredness
  • weakness
  • loss of appetite
  • nausea and vomiting
  • yellowing of the whites of your eyes or skin
  • color changes in your stools

Tourette’s syndrome drug
  • pimozide

Taking Viekira Pak with pimozide increases your risk of an irregular heart rate.

HIV drugs
  • efavirenz

Taking this medication with Viekira Pak can increase your liver enzyme levels, which can lead to liver damage.

  • atazanavir/ritonavir

Taking this medication with Viekira Pak can increase the amount of atazanavir/ritonavir in your body. This can increase your risk of side effects.

  • rilpivirine

Taking this medication with Viekira Pak can increase the amount of rilpivirine in your body. This can increase your risk of irregular heart rhythm.

  • darunavir/ritonavir

Taking this medication with Viekira Pak can decrease the amount of darunavir in your body. This can make your HIV treatment less effective.

  • lopinavir/ritonavir

Taking this medication with Viekira Pak can increase the amount of paritaprevir in your body. This can increase your risk of side effects.

Erectile dysfunction drug
  • sildenafil

The side effects of sildenafil may increase when you take it with Viekira Pak. These side effects include:

  • vision problems
  • sudden drop in blood pressure
  • short-term loss of consciousness and fainting
  • an erection lasting more than 4 hours

Sedatives
  • triazolam
  • midazolam

The levels of these two drugs in your body can increase when you take them with Viekira Pak. This can increase your risk of excessive drowsiness or slowed or stopped breathing.

Heart medications
  • amiodarone
  • bepridil
  • disopyramide
  • flecainide
  • lidocaine (oral)
  • mexiletine
  • propafenone
  • quinidine

The levels of these medications can increase in your body and cause serious side effects when you take them with Viekira Pak. Side effects may include changes in blood pressure or heart rhythm.

Antifungals
  • ketoconazole
  • voriconazole

Taking Viekira Pak with either of these drugs changes the levels of these drugs in your body. It increases the level of ketoconazole, which can increase your risks of side effects. It decreases levels of voriconazole, which can make it less effective.

Blood pressure drugs
  • amlodipine
  • furosemide

Taking Viekira Pak with these drugs increases your risk of extremely low blood pressure.

Inhaled corticosteroid to treat breathing problems
  • fluticasone

Taking Viekira Pak with fluticasone increases the level of fluticasone in your body. This increases your risk of side effects.

Immune suppressing drugs
  • everolimus
  • sirolimus
  • tacrolimus

Drug levels increase in your body, putting you at risk for serious or life-threatening side effects. Do not take these drugs with Viekira Pak.

Asthma drug
  • salmeterol

Taking salmeterol with Viekira Pak may increase the levels of salmeterol in your body. This can increase side effects associated with salmeterol, including an irregular heart rate.

Narcotic pain drugs
  • buprenorphine
  • naloxone

Taking Viekira Pak with these drugs can increase the levels of these pain drugs in your body. This can increase your risk of side effects, such as sleepiness or slower brain response.

Stomach acid drug
  • omeprazole

Taking Viekira Pak with omeprazole can decrease the amount of omeprazole in your body. This may make it less effective in treating your symptoms.

Anxiety or sleep problem drug
  • alprazolam

Taking Viekira Pak with alprazolam can increase you risk of side effects from alprazolam.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
People with hepatitis B
People with hepatitis B virus

If you have ever had hepatitis B virus infection, the hepatitis B virus could become active again during or after treatment with this drug. This could cause liver damage, liver failure, or death. Your doctor will check your blood for hepatitis B virus before starting this drug.

 liver problems
People with liver problems

If you have severe liver problems, this drug might not be processed correctly. It may not work as well to treat your hepatitis C infection. It may also put you at risk for toxic side effects. If you have liver cirrhosis, this drug may cause you to need a liver transplant. Taking it may also be fatal (cause death). Your doctor may decide against starting you on the medication depending on how severe your liver problems are.

Pregnant women
Pregnant women

Not enough information is available to know whether this drug poses a risk to a pregnancy. Tell your doctor if you’re pregnant or plan to become pregnant. Viekira Pak should only be used during pregnancy if the potential benefit justifies the potential risk.

Women who are nursing
Women who are breast-feeding

It isn’t known if this medication passes through breast milk. You and your doctor may decide if you’ll take this drug or breastfeed. You shouldn’t do both.

Children
For children

It isn’t known if this drug is safe and effective in children younger than 18 years old.

When to call the doctor
When to call the doctor

Talk to your doctor:

  • if you or your partner are pregnant or plan to become pregnant
  • before starting any new prescription or over-the-counter medications, vitamins, and herbal supplements. Certain medications may affect how this drug works.
Allergies
Allergies

This drug can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives
  • blistering or peeling skin

Don’t take this drug again if you’ve ever had an allergic reaction to it or any of its individual components. Taking it again could be fatal.

SECTION 4 of 4

How to Take Viekira Pak (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Chronic hepatitis C virus infection
Form: Oral tablet
Strength: 12.5 mg ombitasvir/75 mg paritaprevir/50 mg ritonavir/250 mg dasabuvir
Adult dosage (ages 18 years and older)

Take the four tablets daily as follows:

  • Take the two pink tablets (ombitasvir, paritaprevir, and ritonavir) and one of the beige tablets (dasabuvir) in the morning with a meal.
  • Take the other beige tablet (dasabuvir) in the evening with a meal.
Child dosage (ages 0–17 years)

Dosage for people younger than 18 years hasn’t been established.

Special considerations

People with liver transplant and normal liver function and mild fibrosis: You should be treated with Viekira Pak and ribavirin for 24 weeks.

People with liver problems: If you have mild liver problems, no dosage changes are needed. If you have moderate or severe liver problems, don’t use this medication.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don't take it as prescribed.

If you don't take it at all

This drug won’t work to treat your hepatitis C virus infection. The infection will continue to progress and cause more damage to your liver. This infection may be deadly if not treated properly.

If you don't take it on schedule

You may become resistant to this drug and it will no longer work for you. The infection will continue to progress and cause more damage to your liver.

If you take too much

It isn’t fully known what happens when you take too much this drug. If you think you’ve taken too much of this drug, call your doctor or go to the nearest hospital emergency room right away.

What to do if you miss a dose

  • If you miss a dose of the pink tablets and it’s less than 12 hours from the time you usually take your dose, take the missed dose with a meal as soon as possible. Then take your next dose at your usual time with a meal.
  • If you miss a dose of the pink tablets and it’s more than 12 hours from the time you usually take your dose, don’t take the missed dose. Take your next dose at your usual time with a meal.
  • If you miss a dose of the beige tablet and it’s less than 6 hours from the time you usually take your dose, take the missed dose with a meal as soon as possible. Then take your next dose at your usual time with a meal.
  • If you miss a dose of the beige tablet and it’s more than 6 hours from the time you usually take your dose, don’t take the missed dose. Take your next dose at your usual time with a meal.
  • Don’t take more than your prescribed dose of any of the tablets in this drug to make up for a missed dose.

How to tell the drug is working

Your doctor will do blood tests to check the amount of virus in your body. If this drug is working, the amount of virus in your body should decrease. These blood tests may be done before, during, and after treatment with this drug to make sure that the virus is no longer causing infection or inflammation.

This drug is used for short-term treatment.

The length of time you’ll take this drug depends on the type of hepatitis C virus infection you have and whether you also have cirrhosis. Treatment usually lasts 12 or 24 weeks.

Important considerations for taking this drug

Take in the morning and night as directed

The recommended schedule is 2 ombitasvir/paritaprevir/ritonavir tablets once per day in the morning and 1 dasabuvir tablet twice per day, in the morning and evening.

Store at room temperature below 86°F (30ºC). Don’t freeze this drug

Keep it in its original packaging.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store them away from moisture and damp locations.

A prescription for this medication is refillable

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry it with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s preprinted label to identify the medication. Keep the original prescription-labeled box with you when traveling.
  • Be sure you have enough medication before you leave on your trip. It may be difficult to fill this prescription at a pharmacy since they may not have it in stock.

Clinical monitoring

Your doctor will do blood tests to monitor your condition.

  • Your doctor will do blood tests to check how well your liver is working to make sure this drug is still safe for you.
  • Your doctor will also do blood tests to check the amount of hepatitis C virus in your body. If this drug is working, the amount of virus in your body should decrease.
  • These blood tests can be done before, during, and after treatment with this drug to make sure that the virus is no longer causing infection or inflammation.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


Show Sources

  • Viekira Pak (ombitasvir, paritaprevir, and ritonavir tablets; dasabuvir tablets), co-packaged for oral use. (2017). https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/206619s013s015lbl.pdf

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by University of Illinois-Chicago, Drug Information Group on June 15, 2017

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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