Estrogens are a group of 25 steroid hormones that regulate several body functions in both men and w...
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Estrogens are a group of 25 steroid hormones that regulate several body functions in both men and women. In women, it is the primary sex hormone and is produced in the ovaries from cholesterol. It is released into the blood stream from the ovaries, and within seconds it is transported to all parts of the body. Estrogen works by crossing into body cells through a pore in the cell membrane and binds with an estrogen receptor. The receptor-estrogen complex enters the nucleus, binds with DNA, and creates messenger RNA or MRNA. MRNA leaves the nucleus and enters the endoplasmic reticulum, where it creates a specific protein. Proteins are involved in all processes within the body. When estrogen levels fall during menopause, fewer of certain proteins are made which causes changes in how the body functions. One of the effects is to change the hypothalamic thermostat that controls how you perceive hot and cold. A room that used to feel normal now feels hot. Your body's response to heat is to trigger sweating and dilates skin's surface vessels causing flushing of the skin, called a hot flash.