Drug Notebook

FDA Alerts

Special Alerts:

[Posted 06/16/2008] FDA notified healthcare professionals that both conventional and atypical antipsychotics are associated with an increased risk of mortality in elderly patients treated for dementia-related psychosis. In April 2005, FDA notified healthcare professionals that patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death. Since issuing that notification, FDA has reviewed additional information that indicates the risk is also associated with conventional antipsychotics. Antipsychotics are not indicated for the treatment of dementia-related psychosis. The prescribing information for all antipsychotic drugs will now include the same information about this risk in a BOXED WARNING and the WARNINGS section. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2008/safety08.htm#Antipsychotics, http://www.fda.gov/cder/drug/InfoSheets/HCP/antipsychotics_conventional.htm and http://www.fda.gov/bbs/topics/NEWS/2008/NEW01851.html.

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thiothixene
(thye oh THICK seen)

What is thiothixene?
Thiothixene is an antipsychotic medication. It works by changing the actions of chemicals in your brain. Thiothixene is used to treat the symptoms of psychotic conditions, including hallucinations, delusions, and confusion. Thiothixene may also be used for purposes other than those listed in this medication guide.

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What is the price of this medication and similar alternatives?

This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Navane 10MG Capsules PFIZER U.S.90/$175.61 or 270/$510.6
Navane 2MG Capsules PFIZER U.S.90/$84.1 or 270/$242
Navane 20MG Capsules PFIZER U.S.90/$243.49 or 270/$712.8
Navane 5MG Capsules PFIZER U.S.90/$131.3 or 270/$374.76
Thiothixene 1MG Capsules SANDOZ90/$22.99 or 270/$49.98
Thiothixene 10MG Capsules MYLAN100/$31.99 or 300/$81.99
Thiothixene 10MG Capsules SANDOZ90/$49.99 or 270/$145.67
Thiothixene 2MG Capsules MYLAN90/$26.99 or 270/$71.96
Thiothixene 5MG Capsules SANDOZ90/$25.99 or 270/$59.97

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What are the possible side effects of thiothixene?

If you experience any of the following serious side effects, stop taking thiothixene and seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  • uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs; or

  • yellowing of your skin or eyes.

Other, less serious side effects may be more likely to occur. Continue to take thiothixene and talk to your doctor if you experience

  • dizziness or drowsiness,

  • headache,

  • weakness or tremor (shaking),

  • agitation,

  • an increased heart rate,

  • constipation,

  • dry mouth, or

  • weight gain.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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How should I take thiothixene?
Take thiothixene exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you Take each dose with a full glass of water. The liquid form of thiothixene should be mixed in milk, water, fruit juice (not apple), coffee, or a carbonated beverage (noncola soda), then consumed immediately. Do not mix thiothixene with cola or apple juice. Do not stop taking thiothixene without the approval of your doctor. It may be several weeks before you begin to feel better, and you may require continuous treatment for quite some time. Talk to your doctor before you stop taking this medication.

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What is the most important information I should know about thiothixene?
Call your doctor immediately if you experience uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs. Use caution when driving, operating machinery, or performing other hazardous activities. Thiothixene may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking thiothixene.

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What happens if I miss a dose?
Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.

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What other drugs will affect thiothixene?
Thiothixene may increase the side effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (medicines that treat insomnia), pain relievers, anxiety medicines, muscle relaxants, and any other drug that makes you feel sleepy or relaxed. Tell your doctor about all medicines that you are taking and do not take any medicine unless your doctor approves. Drugs other than those listed here may also interact with thiothixene. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

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Can I take this if I am pregnant or trying to get pregnant or if I am breastfeeding?

Thiothixene has not been formally assigned to a pregnancy category by the FDA. Animal studies have shown a decrease in conception rate, decreased litter size, and an increase in the rate of fetal resorption. There are no controlled data in human pregnancy. Thiothixene should only be given during pregnancy when benefit outweighs risk.

There are no data on the excretion of thiothixene into human milk.

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Who should NOT use this medication?

  • Circulatory collapse.
  • Comatose states or CNS depression from any cause. (See Specific Drugs and Laboratory Tests under Interactions.)
  • Blood dyscrasias.
  • Known hypersensitivity to thiothixene. Not known if cross-sensitivity exists between thioxanthenes and phenothiazines; consider possibility that cross-sensitivity may occur.

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What does my medication look like?
Thiothixene is available with a prescription generically and under the brand name Navane. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you. Navane 1 mg--yellow and orange capsules Navane 2 mg-- yellow and blue capsules Navane 5 mg--orange and white capsules Navane 10 mg--blue and white capsules Navane 20 mg--dark-blue and light-blue capsules

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What happens if I overdose?
Seek emergency medical attention. Symptoms of an thiothixene overdose include drowsiness, slurred speech, agitation, restlessness, convulsions, fever, an irregular heartbeat, coma, and death.

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What should I discuss with my healthcare provider before taking thiothixene?
Before taking this medication, tell your doctor if you have liver disease or other problems with your liver; kidney disease; heart disease or other heart problems such as high blood pressure, a previous heart attack, or irregular heartbeats; seizures or epilepsy; an enlarged prostate or difficulty urinating; or glaucoma. You may not be able to take thiothixene, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above. It is not known whether thiothixene will harm an unborn baby. Do not take thiothixene without first talking to your doctor if you are pregnant.

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Can I stop taking the medication if I feel better?
As a general rule, you should always take your medications exactly as prescribed and do not change the dosage or stop taking the medication without first discussing it with your healthcare provider.

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I am on so many medications; do I have to take them all?
This is called polypharmacy—many different medications being used at the same time by one person. Sometimes, being on multiple medications is acceptable and appropriate but at other times it may be problematic. If you are receiving your medications from multiple physicians you need to ensure that they all know what medications you are taking. The best way to do this is to make a list of all the medications you are currently using, including all nutritional supplements, homeopathic remedies, vitamins and over-the-counter drugs (if possible, also include all the diseases you have been diagnosed with). Give a copy to every doctor who takes care of you so they have it on file, this way they can avoid duplicating medications and perhaps even try to consolidate some. After every doctor's visit remember to update the list accordingly. Also, as much as you possibly can, try to use the same pharmacy to fill all your prescriptions, this way any potential drug interactions can be caught and averted.

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Where can I get more information?
More Information

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