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Drug Notebook

FDA Alerts

Special Alerts:

[Posted 05/02/2007] FDA notified healthcare professionals that the Agency proposed that makers of all antidepressant medications update the existing black box warning on the prescribing information for their products to include warnings about the increased risks of suicidal thinking and behavior in young adults ages 18 to 24 years old during the first one to two months of treatment. The proposed labeling changes also state that scientific data did not show this increased risk in adults older than 24 years of age and that adults 65 years of age and older taking antidepressants have a decreased risk of suicidality. The proposed updates apply to the entire category of antidepressants. Individuals currently taking prescribed antidepressant medications should not stop taking them and should notify their healthcare professional if they have concerns. Manufacturers of antidepressant medications will have 30 days to submit their revised product labeling and revised Medication Guides to FDA for review. See the FDA press release for the list of products affected by the proposed antidepressant product labeling changes. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2007/safety07.htm#Antidepressant, http://www.fda.gov/bbs/topics/NEWS/2007/NEW01624.html and http://www.fda.gov/cder/drug/antidepressants/default.htm.

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quetiapine
(kwe TYE a peen)

What is this medicine?
QUETIAPINE (kwe TYE a peen) is an antipsychotic. It is used to treat schizophrenia and bipolar disorder, also known as manic-depression.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

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What is the price of this medication and similar alternatives?

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 09/2009. For the most current and up-to-date pricing information, please visit www.drugstore.com. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

SEROquel 100MG Tablets ASTRAZENECA60/$290.16 or 180/$847.28
SEROquel 200MG Tablets ASTRAZENECA60/$533.87 or 180/$1566.92
SEROquel 25MG Tablets ASTRAZENECA60/$162.29 or 180/$464.94
SEROquel 300MG Tablets ASTRAZENECA60/$703.25 or 180/$2035.12
SEROquel 400MG Tablets ASTRAZENECA30/$430.06 or 90/$1164.06
SEROquel 50MG Tablets ASTRAZENECA100/$452.64 or 300/$1323.15

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What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • difficulty swallowing
  • fast or irregular heartbeat
  • fever or chills, sore throat
  • increased hunger or thirst
  • increased urination
  • problems with balance, talking, walking
  • seizures
  • stiff muscles
  • suicidal thoughts or other mood changes
  • uncontrollable head, mouth, neck, arm, or leg movements
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • change in sex drive or performance
  • constipation
  • drowsy or dizzy
  • dry mouth
  • stomach upset
  • weight gain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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How should I use this medicine?
Take this medicine by mouth. Swallow it with a drink of water. Follow the directions on the prescription label. If it upsets your stomach you can take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on the advice of your doctor or health care professional.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Patients over age 65 years may have a stronger reaction to this medicine and need smaller doses.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

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What may interact with this medicine?
Do not take this medicine with any of the following medications:

  • chlorpromazine
  • cisapride
  • droperidol
  • grepafloxacin
  • halofantrine
  • mesoridazine
  • pimozide
  • sparfloxacin
  • thioridazine

This medicine may also interact with the following medications:

  • alcohol
  • antifungal medicines like fluconazole, itraconazole, ketoconazole, or voriconazole
  • antiviral medicines for HIV or AIDS
  • cimetidine
  • erythromycin
  • haloperidol
  • lorazepam
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for diabetes
  • medicines for high blood pressure
  • medicines for Parkinson's disease
  • medicines for seizures like carbamazepine, phenobarbital, phenytoin
  • rifampin
  • steroid medicines like prednisone or cortisone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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Who should NOT use this medication?

  • Known hypersensitivity to quetiapine or any ingredient in the formulation.

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What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress. It may be several weeks before you see the full effects of this medicine.

Your health care provider may suggest that you have your eyes examined prior to starting this medicine, and every 6 months thereafter.

If you have been taking this medicine regularly for some time, do not suddenly stop taking it. You must gradually reduce the dose or your symptoms may get worse. Ask your doctor or health care professional for advice.

Patients and their families should watch out for worsening depression or thoughts of suicide. Also watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of antidepressant treatment or after a change in dose, call your health care professional.

You may get dizzy or drowsy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase dizziness and drowsiness. Avoid alcoholic drinks.

Do not treat yourself for colds, diarrhea or allergies. Ask your doctor or health care professional for advice, some ingredients may increase possible side effects.

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What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:

  • brain tumor or head injury
  • breast cancer
  • cataracts
  • diabetes
  • difficulty swallowing
  • heart disease
  • kidney disease
  • liver disease
  • low blood counts, like low white cell, platelet, or red cell counts
  • low blood pressure or dizziness when standing up
  • Parkinson's disease
  • previous heart attack
  • seizures
  • suicidal thoughts, plans, or attempt by you or a family member
  • thyroid disease
  • an unusual or allergic reaction to quetiapine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

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Can I stop taking the medication if I feel better?
As a general rule, you should always take your medications exactly as prescribed and do not change the dosage or stop taking the medication without first discussing it with your healthcare provider.

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I am on so many medications; do I have to take them all?
This is called polypharmacy—many different medications being used at the same time by one person. Sometimes, being on multiple medications is acceptable and appropriate but at other times it may be problematic. If you are receiving your medications from multiple physicians you need to ensure that they all know what medications you are taking. The best way to do this is to make a list of all the medications you are currently using, including all nutritional supplements, homeopathic remedies, vitamins and over-the-counter drugs (if possible, also include all the diseases you have been diagnosed with). Give a copy to every doctor who takes care of you so they have it on file, this way they can avoid duplicating medications and perhaps even try to consolidate some. After every doctor's visit remember to update the list accordingly. Also, as much as you possibly can, try to use the same pharmacy to fill all your prescriptions, this way any potential drug interactions can be caught and averted.

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Where can I get more information?
More Information

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