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Drug Notebook

FDA Alerts

  • Oral ketoconazole has been associated with hepatoxicity, including some fatalities. Inform patients of the risk and monitor closely.
  • Concomitant use with cisapride or with astemizole or terfenadine (drugs no longer commercially available in the US) is contraindicated. Pharmacokinetic interactions can occur and serious cardiovascular events have been reported with concomitant use. VT, VF, and torsades de pointes have been reported in patients receiving concomitant cisapride; death, VT, and torsades de pointes have been reported in patients receiving concomitant terfenadine. (See Interactions.)

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ketoconazole
(kee toe KON na zole)

What is this medicine?
KETOCONAZOLE (kee toe KON na zole) is an antifungal medicine. It is used to treat certain kinds of fungal or yeast infections.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

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What is the price of this medication and similar alternatives?

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 09/2009. For the most current and up-to-date pricing information, please visit www.drugstore.com. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Ketoconazole 200MG Tablets TARO14/$30.99 or 42/$88.99
Nizoral 200MG Tablets JANSSEN14/$64.27 or 42/$183.46

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What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • dark urine
  • feeling dizzy, faint
  • fever
  • irregular heartbeat, chest pain
  • light color stools
  • loss of appetite
  • usually tired or weak
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • breast swelling and tenderness
  • change in sex drive or performance
  • eyes more sensitive to light
  • headache
  • nausea, vomiting
  • stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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How should I use this medicine?
Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. This medicine works best if you take it with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

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What may interact with this medicine?
Do not take this medicine with any of the following medications:

  • alfuzosin
  • cisapride
  • conivaptan
  • dofetilide
  • eplerenone
  • ergotamine, dihydroergotamine or methysergide
  • medicines for high cholesterol like atorvastatin
  • nevirapine
  • pimozide
  • quinidine
  • sirolimus
  • some medicines for anxiety or difficulty sleeping like alprazolam, midazolam or triazolam
  • red yeast rice

This medicine may also interact with the following medications:

  • atropine and related drugs like hyoscyamine, scopolamine, tolterodine and others
  • cyclosporine
  • digoxin
  • hormones like methylprednisolone or cortisone
  • medicines for blood sugar
  • medicines for stomach acid or heartburn
  • phenytoin
  • rifampin
  • tacrolimus
  • warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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Who should NOT use this medication?

  • Hypersensitivity to ketoconazole.
  • Concomitant use with certain drugs metabolized by CYP3A4 isoenzymes (e.g., astemizole [no longer commercially available in the US], cisapride, midazolam, terfenadine [no longer commercially available in the US], triazolam). (See Specific Drugs under Interactions.)

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What should I watch for while using this medicine?
Visit your doctor or health care professional for check ups. Tell your doctor if your symptoms do not improve. Some fungal infections can take many weeks or months of treatment to cure.

Avoid medicines for your stomach like antacids, anticholinergics, and acid blockers for at least two hours after taking this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

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What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:

  • an alcohol abuse problem
  • low stomach acid production
  • liver disease
  • an unusual or allergic reaction to ketoconazole, itraconazole, miconazole, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

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Can I stop taking the medication if I feel better?
If you have been diagnosed with a disease for which an antibiotic is needed, you must complete the prescribed course of treatment. Even if you start to feel better, do not skip any doses and remember to take the medication until it is all gone.

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I am on so many medications; do I have to take them all?
This is called polypharmacy—many different medications being used at the same time by one person. Sometimes, being on multiple medications is acceptable and appropriate but at other times it may be problematic. If you are receiving your medications from multiple physicians you need to ensure that they all know what medications you are taking. The best way to do this is to make a list of all the medications you are currently using, including all nutritional supplements, homeopathic remedies, vitamins and over-the-counter drugs (if possible, also include all the diseases you have been diagnosed with). Give a copy to every doctor who takes care of you so they have it on file, this way they can avoid duplicating medications and perhaps even try to consolidate some. After every doctor's visit remember to update the list accordingly. Also, as much as you possibly can, try to use the same pharmacy to fill all your prescriptions, this way any potential drug interactions can be caught and averted.

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Where can I get more information?
More Information

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