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Drug Notebook

FDA Alerts

    Cardiovascular Risk
  • Possible increased risk of serious (sometimes fatal) cardiovascular thrombotic events (e.g., MI, stroke). Risk may increase with duration of use. Individuals with cardiovascular disease or risk factors for cardiovascular disease may be at increased risk. (See Cardiovascular Effects under Cautions.)
  • Contraindicated for the treatment of pain in the setting of CABG surgery.

    GI Risk
  • Increased risk of serious (sometimes fatal) GI events (e.g., bleeding, ulceration, perforation of the stomach or intestine). Serious GI events can occur at any time and may not be preceded by warning signs and symptoms. Geriatric individuals are at greater risk for serious GI events. (See GI Effects under Cautions.)

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celecoxib
(sell a KOX ib)

What is this medicine?
CELECOXIB (sell a KOX ib) is known as a COX-2 inhibitor, a drug that belongs to the non-steroidal anti-inflammatory drug (NSAID) class. It is used to reduce swelling and to treat pain. This medicine is commonly used for various types of joint and muscular conditions, such as arthritis. It may be also used for bone pain, dental pain, headaches, or painful monthly periods. It may also be used to reduce the number of colon or rectal polyps in certain people.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

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What is the price of this medication and similar alternatives?

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 09/2009. For the most current and up-to-date pricing information, please visit www.drugstore.com. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

CeleBREX 100MG Capsules PFIZER U.S.30/$79.79 or 90/$220.47
CeleBREX 200MG Capsules PFIZER U.S.30/$123.89 or 90/$356.99
CeleBREX 400MG Capsules PFIZER U.S.30/$184.79 or 90/$531.23

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What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • black or bloody stools, blood in the urine or vomit
  • blurred vision
  • breathing problems
  • chest pain
  • nausea, vomiting
  • problems with balance, talking, walking
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • unexplained weight gain or swelling
  • unusually weak or tired
  • yellowing of eyes, skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation or diarrhea
  • dizziness
  • gas or heartburn
  • upset stomach

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How should I use this medicine?
Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take it with food if it upsets your stomach or if you take 400 mg at one time. Try to not lie down for at least 10 minutes after you take the medicine. Take the medicine at the same time each day. Do not take more medicine than you are told to take. Long-term, continuous use may increase the risk of heart attack or stroke.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

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What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

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What may interact with this medicine?
Do not take this medicine with any of the following medications:

  • cidofovir
  • methotrexate
  • other NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • pemetrexed

This medicine may also interact with the following medications:

  • alcohol
  • aspirin and aspirin-like drugs
  • diuretics
  • fluconazole
  • lithium
  • medicines for high blood pressure
  • steroid medicines like prednisone or cortisone
  • warfarin

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Who should NOT use this medication?

  • Known hypersensitivity to celecoxib, sulfonamides, or any ingredient in the formulation.
  • History of asthma, urticaria, or other sensitivity reaction precipitated by aspirin or other NSAIAs.
  • Treatment of perioperative pain in the setting of CABG surgery.

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What should I watch for while using this medicine?
Tell your doctor or health care professional if your pain does not get better. Talk to your doctor before taking another medicine for pain. Do not treat yourself.

This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional.

Do not take medicines such as ibuprofen and naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.

This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can happen without warning symptoms and can cause death.

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What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:

  • asthma
  • coronary artery bypass graft (CABG) surgery within the past 2 weeks
  • drink more than 3 alcohol-containing drinks a day
  • heart disease or circulation problems like heart failure or leg edema (fluid retention)
  • high blood pressure
  • kidney disease
  • liver disease
  • stomach bleeding or ulcers
  • an unusual or allergic reaction to celecoxib, sulfa drugs, aspirin, other NSAIDs, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

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Can I stop taking the medication if I feel better?
If you are taking an analgesic for pain and you are no longer experiencing the pain you may stop using the medication. In general, pain medications are to be used on an ?as needed? basis.

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I am on so many medications; do I have to take them all?
This is called polypharmacy—many different medications being used at the same time by one person. Sometimes, being on multiple medications is acceptable and appropriate but at other times it may be problematic. If you are receiving your medications from multiple physicians you need to ensure that they all know what medications you are taking. The best way to do this is to make a list of all the medications you are currently using, including all nutritional supplements, homeopathic remedies, vitamins and over-the-counter drugs (if possible, also include all the diseases you have been diagnosed with). Give a copy to every doctor who takes care of you so they have it on file, this way they can avoid duplicating medications and perhaps even try to consolidate some. After every doctor's visit remember to update the list accordingly. Also, as much as you possibly can, try to use the same pharmacy to fill all your prescriptions, this way any potential drug interactions can be caught and averted.

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Where can I get more information?
More Information

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