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What causes swollen lymph nodes and tired? 14 possible conditions

See a list of possible causes in order from the most common to the least.


Infectious Mononucleosis

Infectious mononucleosis, or "mono," is a group of symptoms caused by the Epstein-Barr virus. One potential symptom is a pink rash that looks like the measles.

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Leukemia is a cancer of the blood cells. Excessive sweating at night, fatigue, weight loss, bone pain, and easy bleeding or bruising are signs of this disease.

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Hodgkin's Disease

Hodgkin's disease is a type of lymphoma, a blood cancer that starts in the lymphatic system. It can occur at any age, but is most prevalent between the ages of 15 and 40 and after the age of 55.

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Syphilis is a sexually transmitted infection. It is caused by a type of bacteria known as Treponema pallidum. According to the Centers for Disease Control and Prevention, in 2006, more than 36,000 cases of syphilis wer...

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Acute HIV Infection

Acute HIV infection is the primary stage of infection by the human immunodeficiency virus. There are several telltale symptoms, one of which is a rash.

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Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease and the most common type of lupus. One of its common symptoms is a rash on the cheeks and nose called a "butterfly rash."

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Learn about sarcoidosis and its causes, symptoms, diagnosis, treatment, and potential complications.

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Burkitt's Lymphoma

Burkitt's lymphoma is a relatively rare and aggressive form of non-Hodgkin's lymphoma, a type of cancer of the lymphatic system. It's most common in children living in sub-Saharan Africa.

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Toxoplasmosis is an infection caused by parasites found in cat feces and undercooked meat, symptoms of which include swollen lymph nodes and fever.

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Sjogren's Syndrome

Sjögren's syndrome is an autoimmune disorder that affects the glands that help the body create moisture in the eyes and mouth. Women are most likely to be affected.

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West Nile Virus Infection (West Nile Fever)

Spread by mosquitos, West Nile virus symptoms can vary in severity. Diarrhea and abdominal pain usually appears within two weeks of infection.

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Rheumatoid Arthritis Overview

Rheumatoid arthritis (RA) is an autoimmune disease, a disease in which the immune system mistakes the body's own cells for invaders. In RA, the immune system attacks the synovia, the membranes lining the joints.

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Brucellosis is a rare disease usually spread through ingesting infected raw meat and unpasteurized milk. Back pain, lethargy, chills, and fever may occur and could lead to complications.

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Dengue Fever

Dengue fever is a disease that affects much of the tropical region and is caused by one of four dengue viruses. A skin rash between two and five days after the initial fever is a common symptom.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.