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What causes swollen ankle and unintentional weight loss? 8 possible conditions

See a list of possible causes in order from the most common to the least.



Cirrhosis is the severe scarring and poor function of the liver caused by long-term exposure to toxins such as alcohol or viral infections.

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Nutritional Deficiencies (Malnutrition)

A nutritional deficiency occurs when the body doesn't absorb the necessary amount of a nutrient. Deficiencies can lead to a variety of health problems.

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Emphysema is a lung disease that, along with chronic bronchitis, represents a type of chronic obstructive pulmonary disease (COPD). Lack of oxygen may give skin and lips a bluish hue.

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Glomerulonephritis is a serious illness that can be life-threatening and requires immediate treatment. The condition is sometimes called nephritis.

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Chronic Kidney Disease

Chronic kidney disease (CKD) is the progressive and irreversible destruction of the kidneys. The most common causes of CKD are high blood pressure and diabetes.

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Infective Endocarditis

Infective endocarditis is an infection of the heart, normally caused by bacteria in the blood stream. It is a serious medical condition. If left untreated, the infection can damage your heart and may even cause death.

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Endocarditis is inflammation of the inner lining of the heart. Possible symptoms of this condition include pale skin, chills, and night sweats.

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ALS (Lou Gehrig's Disease)

Amyotrophic Lateral Sclerosis (ALS) is not contagious. It is a degenerative disease that affects the brain and spinal cord. A chronic disorder, it causes a loss of control of voluntary muscles. The nerves controllin...

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.